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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SCAP
Full Name:
Sterol regulatory element-binding protein cleavage-activating protein
Alias:
KIAA0199; SREBF chaperone; SREBP cleavage activating protein; SREBP cleavage-activating protein; Sterol regulatory element-binding protein cleavage-activating protein: Sterol regulatory element-binding protein cleavage-activating protein: Sterol regulatory element-binding protein cleavage-activating protein
Type:
Mass (Da):
139729
Number AA:
1279
UniProt ID:
Q12770
International Prot ID:
IPI00006280
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0031410
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0051082
PhosphoSite+
KinaseNET
Biological Process:
GO:0008203
GO:0045541
GO:0045716
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
E
R
L
R
E
K
I
S
R
A
F
Y
N
H
G
Site 2
Y16
E
K
I
S
R
A
F
Y
N
H
G
L
L
C
A
Site 3
T59
T
G
P
V
E
F
T
T
P
V
K
D
Y
S
P
Site 4
Y64
F
T
T
P
V
K
D
Y
S
P
P
P
V
D
S
Site 5
S65
T
T
P
V
K
D
Y
S
P
P
P
V
D
S
D
Site 6
S71
Y
S
P
P
P
V
D
S
D
R
K
Q
G
E
P
Site 7
T79
D
R
K
Q
G
E
P
T
E
Q
P
E
W
Y
V
Site 8
Y85
P
T
E
Q
P
E
W
Y
V
G
A
P
V
A
Y
Site 9
S120
D
V
F
R
S
P
L
S
R
A
F
Q
L
V
E
Site 10
S137
R
N
H
V
L
R
D
S
S
G
I
R
S
L
E
Site 11
S138
N
H
V
L
R
D
S
S
G
I
R
S
L
E
E
Site 12
S142
R
D
S
S
G
I
R
S
L
E
E
L
C
L
Q
Site 13
T202
I
H
Q
H
E
P
K
T
L
Q
T
S
A
T
L
Site 14
S221
F
G
V
P
G
K
Y
S
G
V
S
L
Y
T
R
Site 15
Y226
K
Y
S
G
V
S
L
Y
T
R
K
R
M
V
S
Site 16
T235
R
K
R
M
V
S
Y
T
I
T
L
V
F
Q
H
Site 17
Y243
I
T
L
V
F
Q
H
Y
H
A
K
F
L
G
S
Site 18
S261
R
L
M
L
L
H
P
S
P
N
C
S
L
R
A
Site 19
S265
L
H
P
S
P
N
C
S
L
R
A
E
S
L
V
Site 20
S270
N
C
S
L
R
A
E
S
L
V
H
V
H
F
K
Site 21
S311
R
K
I
D
M
V
K
S
K
W
G
L
A
L
A
Site 22
S387
R
I
A
Q
G
L
S
S
E
S
W
S
I
M
K
Site 23
S389
A
Q
G
L
S
S
E
S
W
S
I
M
K
N
M
Site 24
S391
G
L
S
S
E
S
W
S
I
M
K
N
M
A
T
Site 25
S464
P
P
E
A
C
L
P
S
A
K
P
V
G
Q
P
Site 26
Y474
P
V
G
Q
P
T
R
Y
E
R
Q
L
A
V
R
Site 27
S483
R
Q
L
A
V
R
P
S
T
P
H
T
I
T
L
Site 28
T484
Q
L
A
V
R
P
S
T
P
H
T
I
T
L
Q
Site 29
T487
V
R
P
S
T
P
H
T
I
T
L
Q
P
S
S
Site 30
T489
P
S
T
P
H
T
I
T
L
Q
P
S
S
F
R
Site 31
S494
T
I
T
L
Q
P
S
S
F
R
N
L
R
L
P
Site 32
Y508
P
K
R
L
R
V
V
Y
F
L
A
R
T
R
L
Site 33
Y542
D
P
A
G
L
R
N
Y
L
A
A
Q
V
T
E
Site 34
S551
A
A
Q
V
T
E
Q
S
P
L
G
E
G
A
L
Site 35
S571
P
S
G
M
L
P
P
S
H
P
D
P
A
F
S
Site 36
S578
S
H
P
D
P
A
F
S
I
F
P
P
D
A
P
Site 37
T592
P
K
L
P
E
N
Q
T
S
P
G
E
S
P
E
Site 38
S593
K
L
P
E
N
Q
T
S
P
G
E
S
P
E
R
Site 39
S597
N
Q
T
S
P
G
E
S
P
E
R
G
G
P
A
Site 40
S610
P
A
E
V
V
H
D
S
P
V
P
E
V
T
W
Site 41
S629
E
E
L
W
R
K
L
S
F
R
H
W
P
T
L
Site 42
Y639
H
W
P
T
L
F
S
Y
Y
N
I
T
L
A
K
Site 43
S677
R
H
P
Q
D
G
R
S
A
W
P
P
P
G
P
Site 44
Y738
R
V
L
C
P
R
N
Y
G
Q
L
G
G
G
P
Site 45
Y758
G
E
L
P
C
D
D
Y
G
Y
A
P
P
E
T
Site 46
Y760
L
P
C
D
D
Y
G
Y
A
P
P
E
T
E
I
Site 47
T810
A
Q
T
G
D
C
L
T
R
I
P
R
P
G
R
Site 48
S822
P
G
R
Q
R
R
D
S
G
V
G
S
G
L
E
Site 49
S826
R
R
D
S
G
V
G
S
G
L
E
A
Q
E
S
Site 50
S833
S
G
L
E
A
Q
E
S
W
E
R
L
S
D
G
Site 51
S838
Q
E
S
W
E
R
L
S
D
G
G
K
A
G
P
Site 52
S851
G
P
E
E
P
G
D
S
P
P
L
R
H
R
P
Site 53
S865
P
R
G
P
P
P
P
S
L
F
G
D
Q
P
D
Site 54
T874
F
G
D
Q
P
D
L
T
C
L
I
D
T
N
F
Site 55
S887
N
F
S
A
Q
P
R
S
S
Q
P
T
Q
P
E
Site 56
S888
F
S
A
Q
P
R
S
S
Q
P
T
Q
P
E
P
Site 57
T891
Q
P
R
S
S
Q
P
T
Q
P
E
P
R
H
R
Site 58
S904
H
R
A
V
C
G
R
S
R
D
S
P
G
Y
D
Site 59
S907
V
C
G
R
S
R
D
S
P
G
Y
D
F
S
C
Site 60
Y910
R
S
R
D
S
P
G
Y
D
F
S
C
L
V
Q
Site 61
S913
D
S
P
G
Y
D
F
S
C
L
V
Q
R
V
Y
Site 62
Y920
S
C
L
V
Q
R
V
Y
Q
E
E
G
L
A
A
Site 63
S937
T
P
A
L
R
P
P
S
P
G
P
V
L
S
Q
Site 64
S943
P
S
P
G
P
V
L
S
Q
A
P
E
D
E
G
Site 65
S952
A
P
E
D
E
G
G
S
P
E
K
G
S
P
S
Site 66
S957
G
G
S
P
E
K
G
S
P
S
L
A
W
A
P
Site 67
S959
S
P
E
K
G
S
P
S
L
A
W
A
P
S
A
Site 68
S965
P
S
L
A
W
A
P
S
A
E
G
S
I
W
S
Site 69
S969
W
A
P
S
A
E
G
S
I
W
S
L
E
L
Q
Site 70
S972
S
A
E
G
S
I
W
S
L
E
L
Q
G
N
L
Site 71
S1033
N
G
S
L
D
F
F
S
L
E
T
H
T
A
L
Site 72
S1041
L
E
T
H
T
A
L
S
P
L
Q
F
R
G
T
Site 73
T1048
S
P
L
Q
F
R
G
T
P
G
R
G
S
S
P
Site 74
S1053
R
G
T
P
G
R
G
S
S
P
A
S
P
V
Y
Site 75
S1054
G
T
P
G
R
G
S
S
P
A
S
P
V
Y
S
Site 76
S1057
G
R
G
S
S
P
A
S
P
V
Y
S
S
S
D
Site 77
Y1060
S
S
P
A
S
P
V
Y
S
S
S
D
T
V
A
Site 78
S1061
S
P
A
S
P
V
Y
S
S
S
D
T
V
A
C
Site 79
T1065
P
V
Y
S
S
S
D
T
V
A
C
H
L
T
H
Site 80
T1094
A
A
A
G
R
L
V
T
G
S
Q
D
H
T
L
Site 81
S1096
A
G
R
L
V
T
G
S
Q
D
H
T
L
R
V
Site 82
T1100
V
T
G
S
Q
D
H
T
L
R
V
F
R
L
E
Site 83
T1114
E
D
S
C
C
L
F
T
L
Q
G
H
S
G
A
Site 84
T1123
Q
G
H
S
G
A
I
T
T
V
Y
I
D
Q
T
Site 85
S1165
A
H
R
G
D
V
T
S
L
T
C
T
T
S
C
Site 86
S1183
S
G
L
D
D
L
I
S
I
W
D
R
S
T
G
Site 87
T1235
N
Y
G
D
L
L
Q
T
V
Y
L
G
K
N
S
Site 88
Y1237
G
D
L
L
Q
T
V
Y
L
G
K
N
S
E
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation