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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CPSF1
Full Name:
Cleavage and polyadenylation specificity factor subunit 1
Alias:
Cleavage and polyadenylation specific factor 1, 160kDa; Cleavage and polyadenylation specificity factor 160 kDa subunit; Cleavage and polyadenylation specificity factor, 160 kDa subunit; CPSA; CPSF 160 kDa subunit; CPSF160
Type:
RNA binding protein
Mass (Da):
160884
Number AA:
1443
UniProt ID:
Q10570
International Prot ID:
IPI00026219
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005847
GO:0005849
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003723
GO:0003729
PhosphoSite+
KinaseNET
Biological Process:
GO:0000375
GO:0000377
GO:0000398
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
Y
K
Q
A
H
P
P
T
G
L
E
F
S
M
Y
Site 2
Y19
T
G
L
E
F
S
M
Y
C
N
F
F
N
N
S
Site 3
Y39
V
A
G
T
S
Q
L
Y
V
Y
R
L
N
R
D
Site 4
S56
A
L
T
K
N
D
R
S
T
E
G
K
A
H
R
Site 5
T57
L
T
K
N
D
R
S
T
E
G
K
A
H
R
E
Site 6
S97
K
R
D
A
L
L
L
S
F
K
D
A
K
L
S
Site 7
S104
S
F
K
D
A
K
L
S
V
V
E
Y
D
P
G
Site 8
Y108
A
K
L
S
V
V
E
Y
D
P
G
T
H
D
L
Site 9
T112
V
V
E
Y
D
P
G
T
H
D
L
K
T
L
S
Site 10
T117
P
G
T
H
D
L
K
T
L
S
L
H
Y
F
E
Site 11
S119
T
H
D
L
K
T
L
S
L
H
Y
F
E
E
P
Site 12
Y122
L
K
T
L
S
L
H
Y
F
E
E
P
E
L
R
Site 13
T138
G
F
V
Q
N
V
H
T
P
R
V
R
V
D
P
Site 14
Y155
R
C
A
A
M
L
V
Y
G
T
R
L
V
V
L
Site 15
S168
V
L
P
F
R
R
E
S
L
A
E
E
H
E
G
Site 16
S183
L
V
G
E
G
Q
R
S
S
F
L
P
S
Y
I
Site 17
S184
V
G
E
G
Q
R
S
S
F
L
P
S
Y
I
I
Site 18
S188
Q
R
S
S
F
L
P
S
Y
I
I
D
V
R
A
Site 19
T321
T
Q
E
G
V
R
I
T
L
D
C
A
Q
A
T
Site 20
T328
T
L
D
C
A
Q
A
T
F
I
S
Y
D
K
M
Site 21
S338
S
Y
D
K
M
V
I
S
L
K
G
G
E
I
Y
Site 22
S356
L
I
T
D
G
M
R
S
V
R
A
F
H
F
D
Site 23
Y396
G
N
S
L
L
L
K
Y
T
E
K
L
Q
E
P
Site 24
S406
K
L
Q
E
P
P
A
S
A
V
R
E
A
A
D
Site 25
S419
A
D
K
E
E
P
P
S
K
K
K
R
V
D
A
Site 26
S436
G
W
S
A
A
G
K
S
V
P
Q
D
E
V
D
Site 27
Y448
E
V
D
E
I
E
V
Y
G
S
E
A
Q
S
G
Site 28
S450
D
E
I
E
V
Y
G
S
E
A
Q
S
G
T
Q
Site 29
S454
V
Y
G
S
E
A
Q
S
G
T
Q
L
A
T
Y
Site 30
Y461
S
G
T
Q
L
A
T
Y
S
F
E
V
C
D
S
Site 31
S487
V
G
E
P
A
F
L
S
E
E
F
Q
N
S
P
Site 32
S493
L
S
E
E
F
Q
N
S
P
E
P
D
L
E
I
Site 33
S513
H
G
K
N
G
A
L
S
V
L
Q
K
S
I
R
Site 34
S560
E
G
T
E
Q
E
P
S
T
T
P
E
A
D
D
Site 35
T562
T
E
Q
E
P
S
T
T
P
E
A
D
D
D
G
Site 36
S578
R
H
G
F
L
I
L
S
R
E
D
S
T
M
I
Site 37
S598
E
I
M
E
L
D
T
S
G
F
A
T
Q
G
P
Site 38
Y617
G
N
I
G
D
N
R
Y
I
V
Q
V
S
P
L
Site 39
S672
V
T
M
F
L
L
K
S
D
S
Y
G
G
R
H
Site 40
S674
M
F
L
L
K
S
D
S
Y
G
G
R
H
H
R
Site 41
Y675
F
L
L
K
S
D
S
Y
G
G
R
H
H
R
L
Site 42
T697
H
H
Q
S
K
V
I
T
L
C
L
Y
R
D
L
Site 43
T709
R
D
L
S
G
M
F
T
T
E
S
R
L
G
G
Site 44
S712
S
G
M
F
T
T
E
S
R
L
G
G
A
R
D
Site 45
S734
P
E
A
E
G
L
G
S
E
T
S
P
T
V
D
Site 46
T736
A
E
G
L
G
S
E
T
S
P
T
V
D
D
E
Site 47
S737
E
G
L
G
S
E
T
S
P
T
V
D
D
E
E
Site 48
T739
L
G
S
E
T
S
P
T
V
D
D
E
E
E
M
Site 49
Y748
D
D
E
E
E
M
L
Y
G
D
S
G
S
L
F
Site 50
S751
E
E
M
L
Y
G
D
S
G
S
L
F
S
P
S
Site 51
S753
M
L
Y
G
D
S
G
S
L
F
S
P
S
K
E
Site 52
S756
G
D
S
G
S
L
F
S
P
S
K
E
E
A
R
Site 53
S758
S
G
S
L
F
S
P
S
K
E
E
A
R
R
S
Site 54
S765
S
K
E
E
A
R
R
S
S
Q
P
P
A
D
R
Site 55
S766
K
E
E
A
R
R
S
S
Q
P
P
A
D
R
D
Site 56
Y797
E
N
G
T
M
E
I
Y
Q
L
P
D
W
R
L
Site 57
S821
G
Q
R
V
L
V
D
S
S
F
G
Q
P
T
T
Site 58
S822
Q
R
V
L
V
D
S
S
F
G
Q
P
T
T
Q
Site 59
T838
E
A
R
R
E
E
A
T
R
Q
G
E
L
P
L
Site 60
S859
V
A
L
G
S
R
Q
S
R
P
Y
L
L
V
H
Site 61
Y862
G
S
R
Q
S
R
P
Y
L
L
V
H
V
D
Q
Site 62
Y874
V
D
Q
E
L
L
I
Y
E
A
F
P
H
D
S
Site 63
S881
Y
E
A
F
P
H
D
S
Q
L
G
Q
G
N
L
Site 64
Y933
G
R
V
A
R
F
R
Y
F
E
D
I
Y
G
Y
Site 65
Y989
N
C
P
R
G
F
L
Y
F
N
R
Q
G
E
L
Site 66
S999
R
Q
G
E
L
R
I
S
V
L
P
A
Y
L
S
Site 67
Y1024
P
L
R
C
T
A
H
Y
V
A
Y
H
V
E
S
Site 68
Y1034
Y
H
V
E
S
K
V
Y
A
V
A
T
S
T
N
Site 69
T1038
S
K
V
Y
A
V
A
T
S
T
N
T
P
C
A
Site 70
S1039
K
V
Y
A
V
A
T
S
T
N
T
P
C
A
R
Site 71
T1040
V
Y
A
V
A
T
S
T
N
T
P
C
A
R
I
Site 72
T1042
A
V
A
T
S
T
N
T
P
C
A
R
I
P
R
Site 73
T1051
C
A
R
I
P
R
M
T
G
E
E
K
E
F
E
Site 74
Y1066
T
I
E
R
D
E
R
Y
I
H
P
Q
Q
E
A
Site 75
T1105
E
H
V
T
C
M
K
T
V
S
L
R
S
E
E
Site 76
S1107
V
T
C
M
K
T
V
S
L
R
S
E
E
T
V
Site 77
S1110
M
K
T
V
S
L
R
S
E
E
T
V
S
G
L
Site 78
T1113
V
S
L
R
S
E
E
T
V
S
G
L
K
G
Y
Site 79
S1115
L
R
S
E
E
T
V
S
G
L
K
G
Y
V
A
Site 80
T1156
P
E
P
G
Q
P
L
T
K
N
K
F
K
V
L
Site 81
Y1164
K
N
K
F
K
V
L
Y
E
K
E
Q
K
G
P
Site 82
S1194
G
Q
K
I
F
L
W
S
L
R
A
S
E
L
T
Site 83
Y1236
K
S
I
S
L
L
R
Y
Q
E
E
S
K
T
L
Site 84
S1240
L
L
R
Y
Q
E
E
S
K
T
L
S
L
V
S
Site 85
T1242
R
Y
Q
E
E
S
K
T
L
S
L
V
S
R
D
Site 86
S1244
Q
E
E
S
K
T
L
S
L
V
S
R
D
A
K
Site 87
Y1256
D
A
K
P
L
E
V
Y
S
V
D
F
M
V
D
Site 88
S1257
A
K
P
L
E
V
Y
S
V
D
F
M
V
D
N
Site 89
S1272
A
Q
L
G
F
L
V
S
D
R
D
R
N
L
M
Site 90
Y1281
R
D
R
N
L
M
V
Y
M
Y
L
P
E
A
K
Site 91
Y1283
R
N
L
M
V
Y
M
Y
L
P
E
A
K
E
S
Site 92
S1290
Y
L
P
E
A
K
E
S
F
G
G
M
R
L
L
Site 93
T1320
R
T
P
C
R
G
A
T
E
G
L
S
K
K
S
Site 94
S1324
R
G
A
T
E
G
L
S
K
K
S
V
V
W
E
Site 95
S1327
T
E
G
L
S
K
K
S
V
V
W
E
N
K
H
Site 96
T1355
L
L
P
M
Q
E
K
T
Y
R
R
L
L
M
L
Site 97
Y1356
L
P
M
Q
E
K
T
Y
R
R
L
L
M
L
Q
Site 98
T1390
M
L
H
V
D
R
R
T
L
Q
N
A
V
R
N
Site 99
Y1407
D
G
E
L
L
N
R
Y
L
Y
L
S
T
M
E
Site 100
Y1409
E
L
L
N
R
Y
L
Y
L
S
T
M
E
R
S
Site 101
S1411
L
N
R
Y
L
Y
L
S
T
M
E
R
S
E
L
Site 102
T1412
N
R
Y
L
Y
L
S
T
M
E
R
S
E
L
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation