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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AP1B1
Full Name:
AP-1 complex subunit beta-1
Alias:
Adapter-related protein complex 1 beta 1 subunit; Adaptin 1, beta; Adaptor protein complex AP-1 beta-1 subunit; Adaptor-related protein complex 1 beta 1 subunit; ADTB1; AP105A; BAM22; Beta-adaptin 1; Beta-prime-adaptin; CLAPB2; Clathrin assembly protein complex 1 beta large chain; Golgi adaptor HA1/AP1 adaptin beta subunit; Plasma membrane adaptor HA2/AP2 adaptor beta subunit
Type:
Adaptor/scaffold; Membrane, Clathrin adaptor complex, Membrane coat, Cytoplasmic vesicle, Golgi apparatus protein
Mass (Da):
104637
Number AA:
949
UniProt ID:
Q10567
International Prot ID:
IPI00328257
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0030131
GO:0031410
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008565
PhosphoSite+
KinaseNET
Biological Process:
GO:0006897
GO:0006886
GO:0006892
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T2
_
_
_
_
_
_
M
T
D
S
K
Y
F
T
T
Site 2
Y6
_
_
M
T
D
S
K
Y
F
T
T
T
K
K
G
Site 3
T8
M
T
D
S
K
Y
F
T
T
T
K
K
G
E
I
Site 4
S24
E
L
K
A
E
L
N
S
D
K
K
E
K
K
K
Site 5
T42
K
K
V
I
A
S
M
T
V
G
K
D
V
S
A
Site 6
Y76
V
Y
L
Y
L
M
N
Y
A
K
S
Q
P
D
M
Site 7
S79
Y
L
M
N
Y
A
K
S
Q
P
D
M
A
I
M
Site 8
T90
M
A
I
M
A
V
N
T
F
V
K
D
C
E
D
Site 9
Y121
R
V
D
K
I
T
E
Y
L
C
E
P
L
R
K
Site 10
Y136
C
L
K
D
E
D
P
Y
V
R
K
T
A
A
V
Site 11
T140
E
D
P
Y
V
R
K
T
A
A
V
C
V
A
K
Site 12
T164
E
D
Q
G
F
L
D
T
L
K
D
L
I
S
D
Site 13
S170
D
T
L
K
D
L
I
S
D
S
N
P
M
V
V
Site 14
S190
A
L
S
E
I
A
E
S
H
P
S
S
N
L
L
Site 15
S193
E
I
A
E
S
H
P
S
S
N
L
L
D
L
N
Site 16
S194
I
A
E
S
H
P
S
S
N
L
L
D
L
N
P
Site 17
T245
Q
S
I
C
E
R
V
T
P
R
L
S
H
A
N
Site 18
S249
E
R
V
T
P
R
L
S
H
A
N
S
A
V
V
Site 19
Y276
M
L
S
K
D
L
D
Y
Y
G
T
L
L
K
K
Site 20
Y277
L
S
K
D
L
D
Y
Y
G
T
L
L
K
K
L
Site 21
T279
K
D
L
D
Y
Y
G
T
L
L
K
K
L
A
P
Site 22
Y300
S
A
E
P
E
L
Q
Y
V
A
L
R
N
I
N
Site 23
Y333
V
K
Y
N
D
P
I
Y
V
K
L
E
K
L
D
Site 24
Y361
V
L
A
E
L
K
E
Y
A
T
E
V
D
V
D
Site 25
Y421
I
K
D
I
F
R
K
Y
P
N
K
Y
E
S
V
Site 26
Y425
F
R
K
Y
P
N
K
Y
E
S
V
I
A
T
L
Site 27
T431
K
Y
E
S
V
I
A
T
L
C
E
N
L
D
S
Site 28
S438
T
L
C
E
N
L
D
S
L
D
E
P
E
A
R
Site 29
S468
N
A
D
E
L
L
E
S
F
L
E
G
F
H
D
Site 30
S477
L
E
G
F
H
D
E
S
T
Q
V
Q
L
Q
L
Site 31
T478
E
G
F
H
D
E
S
T
Q
V
Q
L
Q
L
L
Site 32
S508
E
L
V
Q
Q
V
L
S
L
A
T
Q
D
S
D
Site 33
S514
L
S
L
A
T
Q
D
S
D
N
P
D
L
R
D
Site 34
Y524
P
D
L
R
D
R
G
Y
I
Y
W
R
L
L
S
Site 35
Y526
L
R
D
R
G
Y
I
Y
W
R
L
L
S
T
D
Site 36
S531
Y
I
Y
W
R
L
L
S
T
D
P
V
A
A
K
Site 37
S572
C
Y
I
G
T
L
A
S
V
Y
H
K
P
P
S
Site 38
S579
S
V
Y
H
K
P
P
S
A
F
V
E
G
G
R
Site 39
S592
G
R
G
V
V
H
K
S
L
P
P
R
T
A
S
Site 40
T597
H
K
S
L
P
P
R
T
A
S
S
E
S
A
E
Site 41
S599
S
L
P
P
R
T
A
S
S
E
S
A
E
S
P
Site 42
S600
L
P
P
R
T
A
S
S
E
S
A
E
S
P
E
Site 43
S602
P
R
T
A
S
S
E
S
A
E
S
P
E
T
A
Site 44
S605
A
S
S
E
S
A
E
S
P
E
T
A
P
T
G
Site 45
T608
E
S
A
E
S
P
E
T
A
P
T
G
A
P
P
Site 46
T611
E
S
P
E
T
A
P
T
G
A
P
P
G
E
Q
Site 47
S665
L
L
G
G
G
L
D
S
L
M
G
D
E
P
E
Site 48
S713
T
S
G
V
G
T
L
S
G
S
Y
V
A
P
K
Site 49
S735
K
A
K
G
L
E
I
S
G
T
F
T
R
Q
V
Site 50
T737
K
G
L
E
I
S
G
T
F
T
R
Q
V
G
S
Site 51
S746
T
R
Q
V
G
S
I
S
M
D
L
Q
L
T
N
Site 52
S786
L
Q
V
H
A
P
L
S
P
N
Q
T
V
E
I
Site 53
S875
L
N
A
E
A
A
S
S
K
L
Q
S
S
N
I
Site 54
S879
A
A
S
S
K
L
Q
S
S
N
I
F
T
V
A
Site 55
S880
A
S
S
K
L
Q
S
S
N
I
F
T
V
A
K
Site 56
T884
L
Q
S
S
N
I
F
T
V
A
K
R
N
V
E
Site 57
Y897
V
E
G
Q
D
M
L
Y
Q
S
L
K
L
T
N
Site 58
S899
G
Q
D
M
L
Y
Q
S
L
K
L
T
N
G
I
Site 59
S920
R
I
Q
P
G
N
P
S
C
T
D
L
E
L
S
Site 60
S927
S
C
T
D
L
E
L
S
L
K
C
R
A
P
E
Site 61
Y940
P
E
V
S
Q
H
V
Y
Q
A
Y
E
T
I
L
Site 62
Y943
S
Q
H
V
Y
Q
A
Y
E
T
I
L
K
N
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation