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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NEXN
Full Name:
Nexilin
Alias:
F-actin binding protein; Nelin; Nexilin (F actin binding protein)
Type:
Unknown function
Mass (Da):
80658
Number AA:
675
UniProt ID:
Q0ZGT2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005924
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0051015
PhosphoSite+
KinaseNET
Biological Process:
GO:0030334
GO:0051493
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
Q
K
A
E
I
L
L
S
S
S
K
P
V
P
K
Site 2
S15
A
E
I
L
L
S
S
S
K
P
V
P
K
T
Y
Site 3
T21
S
S
K
P
V
P
K
T
Y
V
P
K
L
G
K
Site 4
Y22
S
K
P
V
P
K
T
Y
V
P
K
L
G
K
G
Site 5
S50
E
E
R
N
Q
R
R
S
R
D
E
K
Q
R
R
Site 6
Y61
K
Q
R
R
K
E
Q
Y
I
R
E
R
E
W
N
Site 7
S80
E
I
K
E
M
L
A
S
D
D
E
E
D
V
S
Site 8
S87
S
D
D
E
E
D
V
S
S
K
V
E
K
A
Y
Site 9
S88
D
D
E
E
D
V
S
S
K
V
E
K
A
Y
V
Site 10
Y94
S
S
K
V
E
K
A
Y
V
P
K
L
T
G
T
Site 11
T101
Y
V
P
K
L
T
G
T
V
K
G
R
F
A
E
Site 12
T121
Q
E
E
Q
R
K
R
T
E
E
E
R
K
R
R
Site 13
T156
Q
I
E
D
I
N
N
T
G
T
E
S
A
S
E
Site 14
T158
E
D
I
N
N
T
G
T
E
S
A
S
E
E
G
Site 15
S160
I
N
N
T
G
T
E
S
A
S
E
E
G
D
D
Site 16
S168
A
S
E
E
G
D
D
S
L
L
I
T
V
V
P
Site 17
S178
I
T
V
V
P
V
K
S
Y
K
T
S
G
K
M
Site 18
T181
V
P
V
K
S
Y
K
T
S
G
K
M
K
K
N
Site 19
S182
P
V
K
S
Y
K
T
S
G
K
M
K
K
N
F
Site 20
Y204
E
E
K
E
R
I
K
Y
E
E
D
K
R
I
R
Site 21
Y212
E
E
D
K
R
I
R
Y
E
E
Q
R
P
S
L
Site 22
S218
R
Y
E
E
Q
R
P
S
L
K
E
A
K
C
L
Site 23
S241
E
S
E
A
K
K
E
S
L
S
P
G
K
L
K
Site 24
S243
E
A
K
K
E
S
L
S
P
G
K
L
K
L
T
Site 25
T250
S
P
G
K
L
K
L
T
F
E
E
L
E
R
Q
Site 26
T298
E
D
E
E
N
Q
D
T
A
K
I
F
K
G
Y
Site 27
S313
R
P
G
K
L
K
L
S
F
E
E
M
E
R
Q
Site 28
S357
N
M
V
V
D
D
D
S
P
E
M
Y
K
T
I
Site 29
Y361
D
D
D
S
P
E
M
Y
K
T
I
S
Q
E
F
Site 30
T363
D
S
P
E
M
Y
K
T
I
S
Q
E
F
L
T
Site 31
S365
P
E
M
Y
K
T
I
S
Q
E
F
L
T
P
G
Site 32
T370
T
I
S
Q
E
F
L
T
P
G
K
L
E
I
N
Site 33
T393
M
E
E
E
K
R
R
T
E
E
E
R
K
H
K
Site 34
T424
E
E
E
E
E
N
E
T
F
G
L
S
R
E
Y
Site 35
S428
E
N
E
T
F
G
L
S
R
E
Y
E
E
L
I
Site 36
Y431
T
F
G
L
S
R
E
Y
E
E
L
I
K
L
K
Site 37
S440
E
L
I
K
L
K
R
S
G
S
I
Q
A
K
N
Site 38
S442
I
K
L
K
R
S
G
S
I
Q
A
K
N
L
K
Site 39
S450
I
Q
A
K
N
L
K
S
K
F
E
K
I
G
Q
Site 40
S503
D
V
R
P
A
R
K
S
E
A
P
F
T
H
K
Site 41
T508
R
K
S
E
A
P
F
T
H
K
V
N
M
K
A
Site 42
S564
E
E
E
E
E
E
G
S
I
M
N
G
S
T
A
Site 43
S569
E
G
S
I
M
N
G
S
T
A
E
D
E
E
Q
Site 44
S579
E
D
E
E
Q
T
R
S
G
A
P
W
F
K
K
Site 45
S592
K
K
P
L
K
N
T
S
V
V
D
S
E
P
V
Site 46
S596
K
N
T
S
V
V
D
S
E
P
V
R
F
T
V
Site 47
T602
D
S
E
P
V
R
F
T
V
K
V
T
G
E
P
Site 48
T606
V
R
F
T
V
K
V
T
G
E
P
K
P
E
I
Site 49
Y628
I
L
Q
D
G
E
D
Y
Q
Y
I
E
R
G
E
Site 50
Y630
Q
D
G
E
D
Y
Q
Y
I
E
R
G
E
T
Y
Site 51
T636
Q
Y
I
E
R
G
E
T
Y
C
L
Y
L
P
E
Site 52
Y640
R
G
E
T
Y
C
L
Y
L
P
E
T
F
P
E
Site 53
T644
Y
C
L
Y
L
P
E
T
F
P
E
D
G
G
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation