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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RASGEF1B
Full Name:
Ras-GEF domain-containing family member 1B
Alias:
GPI gamma-4
Type:
Mass (Da):
55359
Number AA:
473
UniProt ID:
Q0VAM2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
P
Q
T
P
P
F
S
A
M
F
D
S
S
G
Site 2
S13
P
F
S
A
M
F
D
S
S
G
Y
N
R
N
L
Site 3
Y16
A
M
F
D
S
S
G
Y
N
R
N
L
Y
Q
S
Site 4
Y21
S
G
Y
N
R
N
L
Y
Q
S
A
E
D
S
C
Site 5
S23
Y
N
R
N
L
Y
Q
S
A
E
D
S
C
G
G
Site 6
S27
L
Y
Q
S
A
E
D
S
C
G
G
L
Y
Y
H
Site 7
Y32
E
D
S
C
G
G
L
Y
Y
H
D
N
N
L
L
Site 8
Y33
D
S
C
G
G
L
Y
Y
H
D
N
N
L
L
S
Site 9
S40
Y
H
D
N
N
L
L
S
G
S
L
E
A
L
I
Site 10
S42
D
N
N
L
L
S
G
S
L
E
A
L
I
Q
H
Site 11
Y56
H
L
V
P
N
V
D
Y
Y
P
D
R
T
Y
I
Site 12
Y57
L
V
P
N
V
D
Y
Y
P
D
R
T
Y
I
F
Site 13
Y62
D
Y
Y
P
D
R
T
Y
I
F
T
F
L
L
S
Site 14
Y77
S
R
L
F
M
H
P
Y
E
L
M
A
K
V
C
Site 15
S94
C
V
E
H
Q
R
L
S
D
P
D
S
D
K
N
Site 16
S98
Q
R
L
S
D
P
D
S
D
K
N
Q
M
R
K
Site 17
T115
P
K
I
L
Q
L
L
T
E
W
T
E
T
F
P
Site 18
T120
L
L
T
E
W
T
E
T
F
P
Y
D
F
R
D
Site 19
Y123
E
W
T
E
T
F
P
Y
D
F
R
D
E
R
M
Site 20
S143
D
L
A
H
R
I
A
S
G
E
E
Q
T
Y
R
Site 21
Y149
A
S
G
E
E
Q
T
Y
R
K
N
V
Q
Q
M
Site 22
Y170
K
L
A
A
L
S
Q
Y
E
E
V
L
A
K
I
Site 23
S179
E
V
L
A
K
I
S
S
T
S
T
D
R
L
T
Site 24
T182
A
K
I
S
S
T
S
T
D
R
L
T
V
L
K
Site 25
T186
S
T
S
T
D
R
L
T
V
L
K
T
K
P
Q
Site 26
T190
D
R
L
T
V
L
K
T
K
P
Q
S
I
Q
R
Site 27
S194
V
L
K
T
K
P
Q
S
I
Q
R
D
I
I
T
Site 28
T201
S
I
Q
R
D
I
I
T
V
C
N
D
P
Y
T
Site 29
T208
T
V
C
N
D
P
Y
T
L
A
Q
Q
L
T
H
Site 30
Y223
I
E
L
E
R
L
N
Y
I
G
P
E
E
F
V
Site 31
S244
D
P
L
D
N
D
K
S
C
Y
S
E
R
K
K
Site 32
S247
D
N
D
K
S
C
Y
S
E
R
K
K
T
R
N
Site 33
T252
C
Y
S
E
R
K
K
T
R
N
L
E
A
Y
V
Site 34
Y258
K
T
R
N
L
E
A
Y
V
E
W
F
N
R
L
Site 35
Y267
E
W
F
N
R
L
S
Y
L
V
A
T
E
I
C
Site 36
T271
R
L
S
Y
L
V
A
T
E
I
C
M
P
V
K
Site 37
Y288
H
R
A
R
M
I
E
Y
F
I
D
V
A
R
E
Site 38
S315
I
I
S
G
M
N
M
S
P
V
S
R
L
K
K
Site 39
S318
G
M
N
M
S
P
V
S
R
L
K
K
T
W
A
Site 40
T323
P
V
S
R
L
K
K
T
W
A
K
V
K
T
A
Site 41
S359
L
R
G
A
A
Q
R
S
L
T
A
H
S
S
R
Site 42
T361
G
A
A
Q
R
S
L
T
A
H
S
S
R
E
K
Site 43
S364
Q
R
S
L
T
A
H
S
S
R
E
K
I
V
I
Site 44
S365
R
S
L
T
A
H
S
S
R
E
K
I
V
I
P
Site 45
Y444
V
F
S
E
D
A
L
Y
L
A
S
Y
E
S
E
Site 46
Y448
D
A
L
Y
L
A
S
Y
E
S
E
G
P
E
N
Site 47
S450
L
Y
L
A
S
Y
E
S
E
G
P
E
N
H
I
Site 48
S464
I
E
K
D
R
W
K
S
L
R
S
S
L
L
G
Site 49
S468
R
W
K
S
L
R
S
S
L
L
G
R
V
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation