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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZNF543
Full Name:
Zinc finger protein 543
Alias:
DKFZp434H055; Zinc finger 543; ZN543
Type:
Intracellular, Nucleus protein
Mass (Da):
68456
Number AA:
600
UniProt ID:
Q08ER8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
T
F
E
D
V
A
V
T
F
T
Q
E
E
W
G
Site 2
Y34
D
A
A
Q
R
T
L
Y
Q
E
V
M
L
E
T
Site 3
T71
R
Q
E
L
W
M
A
T
K
D
L
S
Q
S
S
Site 4
S75
W
M
A
T
K
D
L
S
Q
S
S
Y
P
G
D
Site 5
S77
A
T
K
D
L
S
Q
S
S
Y
P
G
D
N
T
Site 6
Y79
K
D
L
S
Q
S
S
Y
P
G
D
N
T
K
P
Site 7
T84
S
S
Y
P
G
D
N
T
K
P
K
T
T
E
P
Site 8
T88
G
D
N
T
K
P
K
T
T
E
P
T
F
S
H
Site 9
T89
D
N
T
K
P
K
T
T
E
P
T
F
S
H
L
Site 10
S94
K
T
T
E
P
T
F
S
H
L
A
L
P
E
E
Site 11
T109
V
L
L
Q
E
R
L
T
Q
G
A
S
K
N
S
Site 12
S113
E
R
L
T
Q
G
A
S
K
N
S
Q
L
G
Q
Site 13
S116
T
Q
G
A
S
K
N
S
Q
L
G
Q
S
K
D
Site 14
S128
S
K
D
Q
D
G
P
S
E
M
Q
E
V
H
L
Site 15
S151
G
K
L
L
E
K
M
S
S
E
R
D
G
L
G
Site 16
S152
K
L
L
E
K
M
S
S
E
R
D
G
L
G
S
Site 17
S159
S
E
R
D
G
L
G
S
D
D
G
V
C
T
K
Site 18
Y179
V
S
T
E
G
D
L
Y
E
C
D
S
H
G
P
Site 19
S183
G
D
L
Y
E
C
D
S
H
G
P
V
T
D
A
Site 20
S198
L
I
R
E
E
K
N
S
Y
K
C
E
E
C
G
Site 21
Y199
I
R
E
E
K
N
S
Y
K
C
E
E
C
G
K
Site 22
T222
V
Q
H
E
R
I
H
T
Q
V
K
P
Y
E
C
Site 23
Y227
I
H
T
Q
V
K
P
Y
E
C
T
E
C
G
K
Site 24
T235
E
C
T
E
C
G
K
T
F
S
K
S
T
H
L
Site 25
S237
T
E
C
G
K
T
F
S
K
S
T
H
L
L
Q
Site 26
T250
L
Q
H
H
I
I
H
T
G
E
K
P
Y
K
C
Site 27
Y255
I
H
T
G
E
K
P
Y
K
C
M
E
C
G
K
Site 28
S268
G
K
A
F
N
R
R
S
H
L
T
R
H
Q
R
Site 29
T271
F
N
R
R
S
H
L
T
R
H
Q
R
I
H
S
Site 30
S278
T
R
H
Q
R
I
H
S
G
E
K
P
Y
K
C
Site 31
Y283
I
H
S
G
E
K
P
Y
K
C
S
E
C
G
K
Site 32
S286
G
E
K
P
Y
K
C
S
E
C
G
K
A
F
T
Site 33
T293
S
E
C
G
K
A
F
T
H
R
S
T
F
V
L
Site 34
S296
G
K
A
F
T
H
R
S
T
F
V
L
H
H
R
Site 35
T297
K
A
F
T
H
R
S
T
F
V
L
H
H
R
S
Site 36
S304
T
F
V
L
H
H
R
S
H
T
G
E
K
P
F
Site 37
T306
V
L
H
H
R
S
H
T
G
E
K
P
F
V
C
Site 38
Y330
R
P
G
F
I
R
H
Y
I
I
H
T
G
E
K
Site 39
T334
I
R
H
Y
I
I
H
T
G
E
K
P
Y
E
C
Site 40
Y339
I
H
T
G
E
K
P
Y
E
C
I
E
C
G
K
Site 41
Y353
K
A
F
N
R
R
S
Y
L
T
W
H
Q
Q
I
Site 42
Y386
S
A
D
L
I
Q
H
Y
I
I
H
T
G
E
K
Site 43
T390
I
Q
H
Y
I
I
H
T
G
E
K
P
Y
K
C
Site 44
S408
G
K
A
F
N
R
R
S
H
L
K
Q
H
Q
R
Site 45
T418
K
Q
H
Q
R
I
H
T
G
E
K
P
Y
E
C
Site 46
Y423
I
H
T
G
E
K
P
Y
E
C
S
E
C
G
K
Site 47
S426
G
E
K
P
Y
E
C
S
E
C
G
K
A
F
T
Site 48
T437
K
A
F
T
H
C
S
T
F
V
L
H
K
R
T
Site 49
T444
T
F
V
L
H
K
R
T
H
T
G
E
K
P
Y
Site 50
T446
V
L
H
K
R
T
H
T
G
E
K
P
Y
E
C
Site 51
Y451
T
H
T
G
E
K
P
Y
E
C
K
E
C
G
K
Site 52
S461
K
E
C
G
K
A
F
S
D
R
A
D
L
I
R
Site 53
S471
A
D
L
I
R
H
F
S
I
H
T
G
E
K
P
Site 54
T474
I
R
H
F
S
I
H
T
G
E
K
P
Y
E
C
Site 55
Y479
I
H
T
G
E
K
P
Y
E
C
V
E
C
G
K
Site 56
S492
G
K
A
F
N
R
S
S
H
L
T
R
H
Q
Q
Site 57
T502
T
R
H
Q
Q
I
H
T
G
E
K
P
Y
E
C
Site 58
Y507
I
H
T
G
E
K
P
Y
E
C
I
Q
C
G
K
Site 59
S526
S
A
N
L
I
R
H
S
I
I
H
T
G
E
K
Site 60
T530
I
R
H
S
I
I
H
T
G
E
K
P
Y
E
C
Site 61
S548
G
K
A
F
N
R
G
S
S
L
T
H
H
Q
R
Site 62
S549
K
A
F
N
R
G
S
S
L
T
H
H
Q
R
I
Site 63
T551
F
N
R
G
S
S
L
T
H
H
Q
R
I
H
T
Site 64
T558
T
H
H
Q
R
I
H
T
G
R
N
P
T
I
V
Site 65
T563
I
H
T
G
R
N
P
T
I
V
T
D
V
G
R
Site 66
T566
G
R
N
P
T
I
V
T
D
V
G
R
P
F
M
Site 67
T574
D
V
G
R
P
F
M
T
A
Q
T
S
V
N
I
Site 68
S578
P
F
M
T
A
Q
T
S
V
N
I
Q
E
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation