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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACSM1
Full Name:
Acyl-coenzyme A synthetase ACSM1, mitochondrial
Alias:
Acyl-CoA synthetase medium-chain family member 1;Butyrate--CoA ligase 1;Butyryl-coenzyme A synthetase 1;Lipoate-activating enzyme;Middle-chain acyl-CoA synthetase 1
Type:
Mass (Da):
65273
Number AA:
577
UniProt ID:
Q08AH1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
H
N
I
H
P
A
P
S
Q
L
R
C
R
S
L
Site 2
S31
P
S
Q
L
R
C
R
S
L
S
E
F
G
A
P
Site 3
S33
Q
L
R
C
R
S
L
S
E
F
G
A
P
R
W
Site 4
Y43
G
A
P
R
W
N
D
Y
E
V
P
E
E
F
N
Site 5
Y54
E
E
F
N
F
A
S
Y
V
L
D
Y
W
A
Q
Site 6
Y58
F
A
S
Y
V
L
D
Y
W
A
Q
K
E
K
E
Site 7
S87
Q
G
D
E
V
K
W
S
F
R
E
M
G
D
L
Site 8
T95
F
R
E
M
G
D
L
T
R
R
V
A
N
V
F
Site 9
Y152
L
K
A
K
D
I
L
Y
R
L
Q
L
S
K
A
Site 10
S177
S
E
V
D
S
I
A
S
Q
C
P
S
L
K
T
Site 11
T184
S
Q
C
P
S
L
K
T
K
L
L
V
S
D
H
Site 12
S189
L
K
T
K
L
L
V
S
D
H
S
R
E
G
W
Site 13
S192
K
L
L
V
S
D
H
S
R
E
G
W
L
D
F
Site 14
S201
E
G
W
L
D
F
R
S
L
V
K
S
A
S
P
Site 15
S205
D
F
R
S
L
V
K
S
A
S
P
E
H
T
C
Site 16
S207
R
S
L
V
K
S
A
S
P
E
H
T
C
V
K
Site 17
T211
K
S
A
S
P
E
H
T
C
V
K
S
K
T
L
Site 18
S215
P
E
H
T
C
V
K
S
K
T
L
D
P
M
V
Site 19
S247
H
G
L
A
L
Q
P
S
F
P
G
S
R
K
L
Site 20
S251
L
Q
P
S
F
P
G
S
R
K
L
R
S
L
K
Site 21
S256
P
G
S
R
K
L
R
S
L
K
T
S
D
V
S
Site 22
T259
R
K
L
R
S
L
K
T
S
D
V
S
W
C
L
Site 23
S260
K
L
R
S
L
K
T
S
D
V
S
W
C
L
S
Site 24
S263
S
L
K
T
S
D
V
S
W
C
L
S
D
S
G
Site 25
T359
Q
E
E
W
K
R
R
T
G
L
L
L
Y
E
N
Site 26
Y364
R
R
T
G
L
L
L
Y
E
N
Y
G
Q
S
E
Site 27
Y367
G
L
L
L
Y
E
N
Y
G
Q
S
E
T
G
L
Site 28
T393
P
G
F
M
G
K
A
T
P
P
Y
D
V
Q
V
Site 29
Y396
M
G
K
A
T
P
P
Y
D
V
Q
V
I
D
D
Site 30
S406
Q
V
I
D
D
K
G
S
I
L
P
P
N
T
E
Site 31
T412
G
S
I
L
P
P
N
T
E
G
N
I
G
I
R
Site 32
Y448
K
V
E
C
G
D
F
Y
N
T
G
D
R
G
K
Site 33
Y461
G
K
M
D
E
E
G
Y
I
C
F
L
G
R
S
Site 34
S475
S
D
D
I
I
N
A
S
G
Y
R
I
G
P
A
Site 35
Y477
D
I
I
N
A
S
G
Y
R
I
G
P
A
E
V
Site 36
S502
A
E
S
A
V
V
G
S
P
D
P
I
R
G
E
Site 37
T530
S
H
D
K
D
Q
L
T
K
E
L
Q
Q
H
V
Site 38
S539
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
Site 39
Y544
V
K
S
V
T
A
P
Y
K
Y
P
R
K
V
E
Site 40
Y546
S
V
T
A
P
Y
K
Y
P
R
K
V
E
F
V
Site 41
T559
F
V
S
E
L
P
K
T
I
T
G
K
I
E
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation