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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLFN5
Full Name:
Schlafen family member 5
Alias:
Type:
Mass (Da):
101055
Number AA:
891
UniProt ID:
Q08AF3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T25
A
G
K
V
T
L
G
T
Q
Q
R
Q
E
M
D
Site 2
Y67
A
E
I
E
N
K
G
Y
N
Y
E
R
H
G
V
Site 3
Y69
I
E
N
K
G
Y
N
Y
E
R
H
G
V
G
L
Site 4
Y118
A
T
L
C
S
N
L
Y
H
R
E
R
T
S
T
Site 5
T123
N
L
Y
H
R
E
R
T
S
T
D
V
M
D
S
Site 6
S124
L
Y
H
R
E
R
T
S
T
D
V
M
D
S
Q
Site 7
T125
Y
H
R
E
R
T
S
T
D
V
M
D
S
Q
E
Site 8
T141
L
A
F
L
K
C
R
T
Q
T
P
T
N
I
N
Site 9
T143
F
L
K
C
R
T
Q
T
P
T
N
I
N
V
S
Site 10
T145
K
C
R
T
Q
T
P
T
N
I
N
V
S
N
S
Site 11
S152
T
N
I
N
V
S
N
S
L
G
P
Q
A
A
Q
Site 12
S161
G
P
Q
A
A
Q
G
S
V
Q
Y
E
G
N
I
Site 13
Y183
F
D
R
K
R
L
Q
Y
L
E
K
L
N
L
P
Site 14
S192
E
K
L
N
L
P
E
S
T
H
V
E
F
V
M
Site 15
S217
D
R
L
P
K
C
V
S
A
F
A
N
T
E
G
Site 16
T249
E
K
E
K
I
D
L
T
S
L
R
A
S
I
D
Site 17
S250
K
E
K
I
D
L
T
S
L
R
A
S
I
D
G
Site 18
S254
D
L
T
S
L
R
A
S
I
D
G
C
I
K
K
Site 19
T269
L
P
V
H
H
F
C
T
Q
R
P
E
I
K
Y
Site 20
Y276
T
Q
R
P
E
I
K
Y
V
L
N
F
L
E
V
Site 21
S312
V
F
A
K
V
P
S
S
W
Q
V
K
D
N
R
Site 22
S340
M
E
A
D
P
D
L
S
R
C
P
E
M
V
L
Site 23
S350
P
E
M
V
L
Q
L
S
L
S
S
A
T
P
R
Site 24
S352
M
V
L
Q
L
S
L
S
S
A
T
P
R
S
K
Site 25
T355
Q
L
S
L
S
S
A
T
P
R
S
K
P
V
C
Site 26
S358
L
S
S
A
T
P
R
S
K
P
V
C
I
H
K
Site 27
Y377
L
K
E
Q
Q
K
R
Y
F
P
V
F
S
D
R
Site 28
S382
K
R
Y
F
P
V
F
S
D
R
V
V
Y
T
P
Site 29
Y387
V
F
S
D
R
V
V
Y
T
P
E
S
L
Y
K
Site 30
T388
F
S
D
R
V
V
Y
T
P
E
S
L
Y
K
E
Site 31
S391
R
V
V
Y
T
P
E
S
L
Y
K
E
L
F
S
Site 32
Y393
V
Y
T
P
E
S
L
Y
K
E
L
F
S
Q
H
Site 33
S398
S
L
Y
K
E
L
F
S
Q
H
K
G
L
R
D
Site 34
T409
G
L
R
D
L
I
N
T
E
M
R
P
F
S
Q
Site 35
S415
N
T
E
M
R
P
F
S
Q
G
I
L
I
F
S
Site 36
Y453
Q
N
N
T
P
I
L
Y
T
I
F
S
K
W
D
Site 37
S499
P
L
V
C
V
L
N
S
D
R
K
A
Q
S
V
Site 38
S505
N
S
D
R
K
A
Q
S
V
Y
S
S
Y
L
Q
Site 39
S509
K
A
Q
S
V
Y
S
S
Y
L
Q
I
Y
P
E
Site 40
Y510
A
Q
S
V
Y
S
S
Y
L
Q
I
Y
P
E
S
Site 41
Y514
Y
S
S
Y
L
Q
I
Y
P
E
S
Y
N
F
M
Site 42
Y518
L
Q
I
Y
P
E
S
Y
N
F
M
T
P
Q
H
Site 43
T522
P
E
S
Y
N
F
M
T
P
Q
H
M
E
A
L
Site 44
Y561
N
L
L
T
N
K
Q
Y
E
L
L
S
K
N
L
Site 45
T571
L
S
K
N
L
R
K
T
R
E
L
F
V
H
G
Site 46
S620
Q
P
L
K
K
L
V
S
F
S
K
K
N
I
C
Site 47
Y662
R
T
E
D
G
D
W
Y
G
K
A
K
F
I
T
Site 48
T671
K
A
K
F
I
T
Q
T
A
R
D
G
P
G
V
Site 49
S692
Y
F
Q
T
Y
H
L
S
C
S
G
L
P
P
P
Site 50
S694
Q
T
Y
H
L
S
C
S
G
L
P
P
P
S
D
Site 51
S700
C
S
G
L
P
P
P
S
D
Q
Y
P
R
E
E
Site 52
Y703
L
P
P
P
S
D
Q
Y
P
R
E
E
I
N
R
Site 53
Y721
N
A
G
P
I
A
N
Y
L
Q
Q
V
M
Q
E
Site 54
S741
P
P
N
L
P
P
G
S
L
V
M
L
Y
E
P
Site 55
Y746
P
G
S
L
V
M
L
Y
E
P
K
W
A
Q
G
Site 56
Y785
R
F
L
L
R
N
G
Y
S
P
K
D
I
A
V
Site 57
S798
A
V
L
F
T
K
A
S
E
V
E
K
Y
K
D
Site 58
Y803
K
A
S
E
V
E
K
Y
K
D
R
L
L
T
A
Site 59
T809
K
Y
K
D
R
L
L
T
A
M
R
K
R
K
L
Site 60
S817
A
M
R
K
R
K
L
S
Q
L
H
E
E
S
D
Site 61
Y885
S
R
A
K
R
H
L
Y
I
L
K
A
S
V
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation