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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADCY2
Full Name:
Adenylate cyclase type 2
Alias:
Adenylate cyclase type II; Adenylyl cyclase; ATP pyrophosphate-lyase; CYA2; EC 4.6.1.1; KIAA1060
Type:
Enzyme, cyclic nucleotide synthesis
Mass (Da):
123603
Number AA:
1091
UniProt ID:
Q08462
International Prot ID:
IPI00328273
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030425
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004016
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0007189
GO:0034199
GO:0006171
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
E
A
M
R
R
R
R
Y
L
R
D
R
S
E
E
Site 2
S16
R
R
Y
L
R
D
R
S
E
E
A
A
G
G
G
Site 3
S29
G
G
D
G
L
P
R
S
R
D
W
L
Y
E
S
Site 4
Y34
P
R
S
R
D
W
L
Y
E
S
Y
Y
C
M
S
Site 5
Y37
R
D
W
L
Y
E
S
Y
Y
C
M
S
Q
Q
H
Site 6
Y282
T
N
N
F
H
N
L
Y
V
K
R
H
T
N
V
Site 7
T287
N
L
Y
V
K
R
H
T
N
V
S
I
L
Y
A
Site 8
S307
T
R
L
A
S
D
C
S
P
G
E
L
V
H
M
Site 9
S350
C
V
S
G
L
P
I
S
L
P
N
H
A
K
N
Site 10
T376
I
K
K
V
R
D
A
T
G
V
D
I
N
M
R
Site 11
S429
P
G
R
V
H
I
S
S
V
T
L
E
H
L
N
Site 12
Y452
D
G
D
I
R
D
P
Y
L
K
Q
H
L
V
K
Site 13
T460
L
K
Q
H
L
V
K
T
Y
F
V
I
N
P
K
Site 14
Y461
K
Q
H
L
V
K
T
Y
F
V
I
N
P
K
G
Site 15
S472
N
P
K
G
E
R
R
S
P
Q
H
L
F
R
P
Site 16
T482
H
L
F
R
P
R
H
T
L
D
G
A
K
M
R
Site 17
S491
D
G
A
K
M
R
A
S
V
R
M
T
R
Y
L
Site 18
T495
M
R
A
S
V
R
M
T
R
Y
L
E
S
W
G
Site 19
Y497
A
S
V
R
M
T
R
Y
L
E
S
W
G
A
A
Site 20
S515
A
H
L
H
H
R
D
S
M
T
T
E
N
G
K
Site 21
T517
L
H
H
R
D
S
M
T
T
E
N
G
K
I
S
Site 22
T518
H
H
R
D
S
M
T
T
E
N
G
K
I
S
T
Site 23
T526
E
N
G
K
I
S
T
T
D
V
P
M
G
Q
H
Site 24
T539
Q
H
N
F
Q
N
R
T
L
R
T
K
S
Q
K
Site 25
S544
N
R
T
L
R
T
K
S
Q
K
K
R
F
E
E
Site 26
S573
A
Q
K
Q
W
L
K
S
E
D
I
Q
R
I
S
Site 27
S580
S
E
D
I
Q
R
I
S
L
L
F
Y
N
K
V
Site 28
Y584
Q
R
I
S
L
L
F
Y
N
K
V
L
E
K
E
Site 29
T595
L
E
K
E
Y
R
A
T
A
L
P
A
F
K
Y
Site 30
S681
N
R
P
W
P
R
I
S
L
T
I
I
T
T
A
Site 31
S704
N
M
F
F
L
S
D
S
E
E
T
I
P
P
T
Site 32
T714
T
I
P
P
T
A
N
T
T
N
T
S
F
S
A
Site 33
T715
I
P
P
T
A
N
T
T
N
T
S
F
S
A
S
Site 34
S718
T
A
N
T
T
N
T
S
F
S
A
S
N
N
Q
Site 35
S722
T
N
T
S
F
S
A
S
N
N
Q
V
A
I
L
Site 36
Y788
H
A
H
V
L
G
D
Y
S
Q
V
L
F
E
R
Site 37
S789
A
H
V
L
G
D
Y
S
Q
V
L
F
E
R
P
Site 38
T804
G
I
W
K
D
L
K
T
M
G
S
V
S
L
S
Site 39
Y826
V
L
G
R
Q
N
E
Y
Y
C
R
L
D
F
L
Site 40
Y827
L
G
R
Q
N
E
Y
Y
C
R
L
D
F
L
W
Site 41
T847
K
E
R
E
E
I
E
T
M
E
N
L
N
R
V
Site 42
S872
A
E
H
F
L
A
R
S
L
K
N
E
E
L
Y
Site 43
Y879
S
L
K
N
E
E
L
Y
H
Q
S
Y
D
C
V
Site 44
Y883
E
E
L
Y
H
Q
S
Y
D
C
V
C
V
M
F
Site 45
S903
F
K
E
F
Y
T
E
S
D
V
N
K
E
G
L
Site 46
S928
A
D
F
D
D
L
L
S
K
P
K
F
S
G
V
Site 47
T940
S
G
V
E
K
I
K
T
I
G
S
T
Y
M
A
Site 48
S952
Y
M
A
A
T
G
L
S
A
V
P
S
Q
E
H
Site 49
S956
T
G
L
S
A
V
P
S
Q
E
H
S
Q
E
P
Site 50
S960
A
V
P
S
Q
E
H
S
Q
E
P
E
R
Q
Y
Site 51
Y967
S
Q
E
P
E
R
Q
Y
M
H
I
G
T
M
V
Site 52
S991
L
D
A
I
N
K
H
S
F
N
D
F
K
L
R
Site 53
Y1018
I
G
A
Q
K
P
Q
Y
D
I
W
G
N
T
V
Site 54
S1029
G
N
T
V
N
V
A
S
R
M
D
S
T
G
V
Site 55
S1033
N
V
A
S
R
M
D
S
T
G
V
L
D
K
I
Site 56
T1058
Q
T
L
G
Y
T
C
T
C
R
G
I
I
N
V
Site 57
T1073
K
G
K
G
D
L
K
T
Y
F
V
N
T
E
M
Site 58
Y1074
G
K
G
D
L
K
T
Y
F
V
N
T
E
M
S
Site 59
S1081
Y
F
V
N
T
E
M
S
R
S
L
S
Q
S
N
Site 60
S1083
V
N
T
E
M
S
R
S
L
S
Q
S
N
V
A
Site 61
S1085
T
E
M
S
R
S
L
S
Q
S
N
V
A
S
_
Site 62
S1087
M
S
R
S
L
S
Q
S
N
V
A
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation