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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EHHADH
Full Name:
Peroxisomal bifunctional enzyme
Alias:
3-hydroxyacyl-CoA dehydrogenase; EC 1.1.1.35; EC 4.2.1.17; EC 5.3.3.8; ECHD; ECHP; Enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase; PBE; PBFE; Peroxisomal bifunctional enzyme
Type:
Lyase; Isomerase; Oxidoreductase; Mitochondrial; Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 5.3.3.8; Amino Acid Metabolism - lysine degradation; Carbohydrate Metabolism - butanoate; Other Amino Acids Metabolism - beta-alanine; Lipid Metabolism - fatty acid; Amino Acid Metabolism - tryptophan; EC 4.2.1.17; Carbohydrate Metabolism - propanoate; EC 1.1.1.35; Secondary Metabolites Metabolism - limonene and pinene degradation
Mass (Da):
79208
Number AA:
722
UniProt ID:
Q08426
International Prot ID:
IPI00216164
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005777
Uniprot
OncoNet
Molecular Function:
GO:0003857
GO:0050662
GO:0004165
PhosphoSite+
KinaseNET
Biological Process:
GO:0006631
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T27
P
V
N
A
I
S
T
T
L
L
R
D
I
K
E
Site 2
S58
C
G
A
E
G
K
F
S
A
G
A
D
I
R
G
Site 3
S67
G
A
D
I
R
G
F
S
A
P
R
T
F
G
L
Site 4
T71
R
G
F
S
A
P
R
T
F
G
L
T
L
G
H
Site 5
T153
P
A
A
L
D
L
I
T
S
G
R
R
I
L
A
Site 6
S189
I
R
F
A
Q
R
V
S
D
Q
P
L
E
S
R
Site 7
S205
L
C
N
K
P
I
Q
S
L
P
N
M
D
S
I
Site 8
Y243
A
V
Q
A
A
V
Q
Y
P
Y
E
V
G
I
K
Site 9
Y258
K
E
E
E
L
F
L
Y
L
L
Q
S
G
Q
A
Site 10
S282
E
R
K
A
N
K
W
S
T
P
S
G
A
S
W
Site 11
T283
R
K
A
N
K
W
S
T
P
S
G
A
S
W
K
Site 12
T291
P
S
G
A
S
W
K
T
A
S
A
R
P
V
S
Site 13
S293
G
A
S
W
K
T
A
S
A
R
P
V
S
S
V
Site 14
S342
T
A
N
K
M
I
T
S
V
L
E
K
E
A
S
Site 15
S349
S
V
L
E
K
E
A
S
K
M
Q
Q
S
G
H
Site 16
S354
E
A
S
K
M
Q
Q
S
G
H
P
W
S
G
P
Site 17
S359
Q
Q
S
G
H
P
W
S
G
P
K
P
R
L
T
Site 18
T366
S
G
P
K
P
R
L
T
S
S
V
K
E
L
G
Site 19
S367
G
P
K
P
R
L
T
S
S
V
K
E
L
G
G
Site 20
S368
P
K
P
R
L
T
S
S
V
K
E
L
G
G
V
Site 21
S387
E
A
V
F
E
E
M
S
L
K
K
Q
V
F
A
Site 22
S420
L
D
V
D
E
I
A
S
S
T
D
R
P
H
L
Site 23
S421
D
V
D
E
I
A
S
S
T
D
R
P
H
L
V
Site 24
T422
V
D
E
I
A
S
S
T
D
R
P
H
L
V
I
Site 25
T431
R
P
H
L
V
I
G
T
H
F
F
S
P
A
H
Site 26
S448
K
L
L
E
V
I
P
S
Q
Y
S
S
P
T
T
Site 27
T455
S
Q
Y
S
S
P
T
T
I
A
T
V
M
N
L
Site 28
T458
S
S
P
T
T
I
A
T
V
M
N
L
S
K
K
Site 29
Y488
G
N
R
M
L
N
P
Y
Y
N
Q
A
Y
F
L
Site 30
Y489
N
R
M
L
N
P
Y
Y
N
Q
A
Y
F
L
L
Site 31
Y493
N
P
Y
Y
N
Q
A
Y
F
L
L
E
E
G
S
Site 32
S533
G
L
D
V
G
W
K
S
R
K
G
Q
G
L
T
Site 33
T548
G
P
T
L
L
P
G
T
P
A
R
K
R
G
N
Site 34
Y558
R
K
R
G
N
R
R
Y
C
P
I
P
D
V
L
Site 35
T575
L
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
Site 36
Y580
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
Site 37
Y582
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
R
I
Site 38
S597
H
K
P
D
P
W
L
S
K
F
L
S
R
Y
R
Site 39
S601
P
W
L
S
K
F
L
S
R
Y
R
K
T
H
H
Site 40
T606
F
L
S
R
Y
R
K
T
H
H
I
E
P
R
T
Site 41
S615
H
I
E
P
R
T
I
S
Q
D
E
I
L
E
R
Site 42
Y650
P
E
H
I
D
V
V
Y
L
H
G
Y
G
W
P
Site 43
Y654
D
V
V
Y
L
H
G
Y
G
W
P
R
H
K
G
Site 44
Y666
H
K
G
G
P
M
F
Y
A
S
T
V
G
L
P
Site 45
Y682
V
L
E
K
L
Q
K
Y
Y
R
Q
N
P
D
I
Site 46
Y683
L
E
K
L
Q
K
Y
Y
R
Q
N
P
D
I
P
Site 47
S695
D
I
P
Q
L
E
P
S
D
Y
L
K
K
L
A
Site 48
Y697
P
Q
L
E
P
S
D
Y
L
K
K
L
A
S
Q
Site 49
S703
D
Y
L
K
K
L
A
S
Q
G
N
P
P
L
K
Site 50
S714
P
P
L
K
E
W
Q
S
L
A
G
S
P
S
S
Site 51
S718
E
W
Q
S
L
A
G
S
P
S
S
K
L
_
_
Site 52
S720
Q
S
L
A
G
S
P
S
S
K
L
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation