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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACTN3
Full Name:
Alpha-actinin-3
Alias:
Actinin, alpha 3; Alpha-actinin-3; F-actin cross linking protein
Type:
Cytoskeletal protein
Mass (Da):
103241
Number AA:
901
UniProt ID:
Q08043
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005884
GO:0005925
GO:0031143
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005509
GO:0005178
PhosphoSite+
KinaseNET
Biological Process:
GO:0048041
GO:0042981
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y26
G
G
G
G
G
G
E
Y
M
E
Q
E
E
D
W
Site 2
T137
V
D
G
N
L
K
M
T
L
G
M
I
W
T
I
Site 3
S154
R
F
A
I
Q
D
I
S
V
E
E
T
S
A
K
Site 4
T158
Q
D
I
S
V
E
E
T
S
A
K
E
G
L
L
Site 5
Y175
C
Q
R
K
T
A
P
Y
R
N
V
N
V
Q
N
Site 6
Y207
H
R
P
D
L
I
D
Y
A
K
L
R
K
D
D
Site 7
T244
D
A
E
D
I
V
N
T
P
K
P
D
E
K
A
Site 8
Y255
D
E
K
A
I
M
T
Y
V
S
C
F
Y
H
A
Site 9
S257
K
A
I
M
T
Y
V
S
C
F
Y
H
A
F
A
Site 10
T271
A
G
A
E
Q
A
E
T
A
A
N
R
I
C
K
Site 11
S298
E
E
Y
E
K
L
A
S
E
L
L
E
W
I
R
Site 12
T307
L
L
E
W
I
R
R
T
V
P
W
L
E
N
R
Site 13
S319
E
N
R
V
G
E
P
S
M
S
A
M
Q
R
K
Site 14
S321
R
V
G
E
P
S
M
S
A
M
Q
R
K
L
E
Site 15
Y333
K
L
E
D
F
R
D
Y
R
R
L
H
K
P
P
Site 16
T357
I
N
F
N
T
L
Q
T
K
L
R
L
S
H
R
Site 17
S362
L
Q
T
K
L
R
L
S
H
R
P
A
F
M
P
Site 18
S370
H
R
P
A
F
M
P
S
E
G
K
L
V
S
D
Site 19
S376
P
S
E
G
K
L
V
S
D
I
A
N
A
W
R
Site 20
S398
G
Y
E
D
W
L
L
S
E
I
R
R
L
Q
R
Site 21
S432
R
G
K
E
E
M
L
S
Q
R
D
Y
D
S
A
Site 22
Y436
E
M
L
S
Q
R
D
Y
D
S
A
L
L
Q
E
Site 23
S438
L
S
Q
R
D
Y
D
S
A
L
L
Q
E
V
R
Site 24
S456
R
R
H
E
A
F
E
S
D
L
A
A
H
Q
D
Site 25
Y480
Q
E
L
N
E
L
D
Y
H
E
A
A
S
V
N
Site 26
S554
Q
D
V
W
L
V
H
S
V
E
E
T
Q
S
L
Site 27
T558
L
V
H
S
V
E
E
T
Q
S
L
L
T
A
H
Site 28
S560
H
S
V
E
E
T
Q
S
L
L
T
A
H
D
Q
Site 29
T595
E
I
Q
K
I
C
Q
T
Y
G
L
R
P
C
S
Site 30
S602
T
Y
G
L
R
P
C
S
T
N
P
Y
I
T
L
Site 31
T603
Y
G
L
R
P
C
S
T
N
P
Y
I
T
L
S
Site 32
Y606
R
P
C
S
T
N
P
Y
I
T
L
S
P
Q
D
Site 33
T608
C
S
T
N
P
Y
I
T
L
S
P
Q
D
I
N
Site 34
S610
T
N
P
Y
I
T
L
S
P
Q
D
I
N
T
K
Site 35
T616
L
S
P
Q
D
I
N
T
K
W
D
M
V
R
K
Site 36
S627
M
V
R
K
L
V
P
S
C
D
Q
T
L
Q
E
Site 37
T631
L
V
P
S
C
D
Q
T
L
Q
E
E
L
A
R
Site 38
T741
L
L
T
S
I
A
R
T
I
N
E
V
E
N
Q
Site 39
S758
T
R
D
A
K
G
L
S
Q
E
Q
L
N
E
F
Site 40
S768
Q
L
N
E
F
R
A
S
F
N
H
F
D
R
K
Site 41
T829
I
D
F
M
T
R
E
T
A
E
T
D
T
T
E
Site 42
T832
M
T
R
E
T
A
E
T
D
T
T
E
Q
V
V
Site 43
T835
E
T
A
E
T
D
T
T
E
Q
V
V
A
S
F
Site 44
Y851
I
L
A
G
D
K
N
Y
I
T
P
E
E
L
R
Site 45
T853
A
G
D
K
N
Y
I
T
P
E
E
L
R
R
E
Site 46
Y876
C
I
R
R
M
V
P
Y
K
G
S
G
A
P
A
Site 47
S879
R
M
V
P
Y
K
G
S
G
A
P
A
G
A
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation