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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SOS2
Full Name:
Son of sevenless homolog 2
Alias:
son of sevenless 2; son of sevenless protein homolog 2; SOS-2
Type:
Adaptor/scaffold; Guanine nucleotide exchange factor, Ras
Mass (Da):
153031
Number AA:
1332
UniProt ID:
Q07890
International Prot ID:
IPI00020134
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005089
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008624
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
P
Q
P
Y
E
F
F
S
E
E
N
S
P
K
W
Site 2
S16
E
F
F
S
E
E
N
S
P
K
W
R
G
L
L
Site 3
S25
K
W
R
G
L
L
V
S
A
L
R
K
V
Q
E
Site 4
S39
E
Q
V
H
P
T
L
S
A
N
E
E
S
L
Y
Site 5
Y46
S
A
N
E
E
S
L
Y
Y
I
E
E
L
I
F
Site 6
Y47
A
N
E
E
S
L
Y
Y
I
E
E
L
I
F
Q
Site 7
T77
V
E
E
R
V
Q
K
T
F
P
H
P
I
D
K
Site 8
S113
P
V
D
K
I
H
P
S
L
K
E
V
L
G
Y
Site 9
Y120
S
L
K
E
V
L
G
Y
K
V
D
Y
H
V
S
Site 10
Y155
Y
V
F
N
I
R
H
Y
E
I
S
Q
Q
D
I
Site 11
S158
N
I
R
H
Y
E
I
S
Q
Q
D
I
K
V
S
Site 12
S185
Q
D
D
I
G
L
V
S
L
C
E
D
E
P
S
Site 13
S192
S
L
C
E
D
E
P
S
S
S
G
E
L
N
Y
Site 14
S193
L
C
E
D
E
P
S
S
S
G
E
L
N
Y
Y
Site 15
S194
C
E
D
E
P
S
S
S
G
E
L
N
Y
Y
D
Site 16
Y200
S
S
G
E
L
N
Y
Y
D
L
V
R
T
E
I
Site 17
Y213
E
I
A
E
E
R
Q
Y
L
R
E
L
N
M
I
Site 18
S230
V
F
R
E
A
F
L
S
D
R
K
L
F
K
P
Site 19
S238
D
R
K
L
F
K
P
S
D
I
E
K
I
F
S
Site 20
S245
S
D
I
E
K
I
F
S
N
I
S
D
I
H
E
Site 21
S248
E
K
I
F
S
N
I
S
D
I
H
E
L
T
V
Site 22
T268
I
E
D
T
V
E
M
T
D
E
S
S
P
H
P
Site 23
S272
V
E
M
T
D
E
S
S
P
H
P
L
A
G
S
Site 24
S279
S
P
H
P
L
A
G
S
C
F
E
D
L
A
E
Site 25
Y293
E
E
Q
A
F
D
P
Y
E
T
L
S
Q
D
I
Site 26
S297
F
D
P
Y
E
T
L
S
Q
D
I
L
S
P
E
Site 27
S302
T
L
S
Q
D
I
L
S
P
E
F
H
E
H
F
Site 28
Y346
R
L
M
L
V
P
V
Y
H
C
W
H
Y
F
E
Site 29
Y351
P
V
Y
H
C
W
H
Y
F
E
L
L
K
Q
L
Site 30
S362
L
K
Q
L
K
A
C
S
E
E
Q
E
D
R
E
Site 31
Y389
Q
G
S
M
D
R
I
Y
K
Q
Y
S
P
R
R
Site 32
Y392
M
D
R
I
Y
K
Q
Y
S
P
R
R
R
P
G
Site 33
S393
D
R
I
Y
K
Q
Y
S
P
R
R
R
P
G
D
Site 34
Y406
G
D
P
V
C
P
F
Y
S
H
Q
L
R
S
K
Site 35
T449
F
I
M
E
G
P
L
T
R
I
G
A
K
H
E
Site 36
Y481
G
Q
T
R
L
P
G
Y
S
S
A
E
Y
R
L
Site 37
S482
Q
T
R
L
P
G
Y
S
S
A
E
Y
R
L
K
Site 38
S483
T
R
L
P
G
Y
S
S
A
E
Y
R
L
K
E
Site 39
Y486
P
G
Y
S
S
A
E
Y
R
L
K
E
K
F
V
Site 40
S516
K
H
A
F
E
L
V
S
K
D
E
N
S
I
I
Site 41
S528
S
I
I
F
A
A
K
S
A
E
E
K
N
N
W
Site 42
S546
L
I
S
L
H
Y
R
S
T
L
D
R
M
L
D
Site 43
T547
I
S
L
H
Y
R
S
T
L
D
R
M
L
D
S
Site 44
S554
T
L
D
R
M
L
D
S
V
L
L
K
E
E
N
Site 45
S569
E
Q
P
L
R
L
P
S
P
E
V
Y
R
F
V
Site 46
Y573
R
L
P
S
P
E
V
Y
R
F
V
V
K
D
S
Site 47
S594
E
D
N
L
Q
S
R
S
G
I
P
I
I
K
G
Site 48
T612
V
K
L
I
E
R
L
T
Y
H
M
Y
A
D
P
Site 49
Y613
K
L
I
E
R
L
T
Y
H
M
Y
A
D
P
N
Site 50
Y616
E
R
L
T
Y
H
M
Y
A
D
P
N
F
V
R
Site 51
T624
A
D
P
N
F
V
R
T
F
L
T
T
Y
R
S
Site 52
T628
F
V
R
T
F
L
T
T
Y
R
S
F
C
K
P
Site 53
Y629
V
R
T
F
L
T
T
Y
R
S
F
C
K
P
Q
Site 54
S631
T
F
L
T
T
Y
R
S
F
C
K
P
Q
E
L
Site 55
S640
C
K
P
Q
E
L
L
S
L
L
I
E
R
F
E
Site 56
T654
E
I
P
E
P
E
P
T
D
A
D
K
L
A
I
Site 57
S669
E
K
G
E
Q
P
I
S
A
D
L
K
R
F
R
Site 58
Y679
L
K
R
F
R
K
E
Y
V
Q
P
V
Q
L
R
Site 59
S714
E
L
L
E
R
L
E
S
F
I
S
S
V
R
G
Site 60
S717
E
R
L
E
S
F
I
S
S
V
R
G
K
A
M
Site 61
S718
R
L
E
S
F
I
S
S
V
R
G
K
A
M
K
Site 62
T751
N
G
V
S
H
N
I
T
F
E
S
P
P
P
P
Site 63
S754
S
H
N
I
T
F
E
S
P
P
P
P
I
E
W
Site 64
T771
S
K
P
G
Q
F
E
T
F
D
L
M
T
L
H
Site 65
S791
R
Q
L
T
L
L
E
S
D
L
Y
R
K
V
Q
Site 66
Y794
T
L
L
E
S
D
L
Y
R
K
V
Q
P
S
E
Site 67
S800
L
Y
R
K
V
Q
P
S
E
L
V
G
S
V
W
Site 68
S805
Q
P
S
E
L
V
G
S
V
W
T
K
E
D
K
Site 69
S816
K
E
D
K
E
I
N
S
P
N
L
L
K
M
I
Site 70
T887
S
V
Y
R
L
D
H
T
F
E
A
L
Q
E
R
Site 71
S906
L
D
E
A
V
E
L
S
Q
D
H
F
K
K
Y
Site 72
Y913
S
Q
D
H
F
K
K
Y
L
V
K
L
K
S
I
Site 73
S919
K
Y
L
V
K
L
K
S
I
N
P
P
C
V
P
Site 74
S957
G
K
D
L
I
N
F
S
K
R
R
K
V
A
E
Site 75
Y972
I
T
G
E
I
Q
Q
Y
Q
N
Q
P
Y
C
L
Site 76
S997
E
N
L
N
P
M
G
S
A
S
E
K
E
F
T
Site 77
S999
L
N
P
M
G
S
A
S
E
K
E
F
T
D
Y
Site 78
T1004
S
A
S
E
K
E
F
T
D
Y
L
F
N
K
S
Site 79
Y1006
S
E
K
E
F
T
D
Y
L
F
N
K
S
L
E
Site 80
S1011
T
D
Y
L
F
N
K
S
L
E
I
E
P
R
N
Site 81
S1029
P
P
R
F
P
R
K
S
T
F
S
L
K
S
P
Site 82
T1030
P
R
F
P
R
K
S
T
F
S
L
K
S
P
G
Site 83
S1032
F
P
R
K
S
T
F
S
L
K
S
P
G
I
R
Site 84
S1035
K
S
T
F
S
L
K
S
P
G
I
R
P
N
T
Site 85
T1042
S
P
G
I
R
P
N
T
G
R
H
G
S
T
S
Site 86
S1047
P
N
T
G
R
H
G
S
T
S
G
T
L
R
G
Site 87
T1048
N
T
G
R
H
G
S
T
S
G
T
L
R
G
H
Site 88
S1049
T
G
R
H
G
S
T
S
G
T
L
R
G
H
P
Site 89
T1051
R
H
G
S
T
S
G
T
L
R
G
H
P
T
P
Site 90
T1057
G
T
L
R
G
H
P
T
P
L
E
R
E
P
C
Site 91
S1067
E
R
E
P
C
K
I
S
F
S
R
I
A
E
T
Site 92
S1069
E
P
C
K
I
S
F
S
R
I
A
E
T
E
L
Site 93
S1078
I
A
E
T
E
L
E
S
T
V
S
A
P
T
S
Site 94
T1079
A
E
T
E
L
E
S
T
V
S
A
P
T
S
P
Site 95
S1081
T
E
L
E
S
T
V
S
A
P
T
S
P
N
T
Site 96
S1085
S
T
V
S
A
P
T
S
P
N
T
P
S
T
P
Site 97
T1088
S
A
P
T
S
P
N
T
P
S
T
P
P
V
S
Site 98
S1090
P
T
S
P
N
T
P
S
T
P
P
V
S
A
S
Site 99
T1091
T
S
P
N
T
P
S
T
P
P
V
S
A
S
S
Site 100
S1095
T
P
S
T
P
P
V
S
A
S
S
D
L
S
V
Site 101
S1131
P
H
S
K
S
F
F
S
S
C
G
S
L
H
K
Site 102
S1132
H
S
K
S
F
F
S
S
C
G
S
L
H
K
L
Site 103
S1135
S
F
F
S
S
C
G
S
L
H
K
L
S
E
E
Site 104
S1140
C
G
S
L
H
K
L
S
E
E
P
L
I
P
P
Site 105
S1160
K
K
F
D
H
D
A
S
N
S
K
G
N
M
K
Site 106
S1162
F
D
H
D
A
S
N
S
K
G
N
M
K
S
D
Site 107
S1168
N
S
K
G
N
M
K
S
D
D
D
P
P
A
I
Site 108
T1193
K
P
R
V
P
V
P
T
G
A
F
D
G
P
L
Site 109
S1202
A
F
D
G
P
L
H
S
P
P
P
P
P
P
R
Site 110
T1215
P
R
D
P
L
P
D
T
P
P
P
V
P
L
R
Site 111
S1246
L
G
H
L
H
R
D
S
D
W
L
R
D
I
S
Site 112
S1253
S
D
W
L
R
D
I
S
T
C
P
N
S
P
S
Site 113
T1254
D
W
L
R
D
I
S
T
C
P
N
S
P
S
T
Site 114
S1258
D
I
S
T
C
P
N
S
P
S
T
P
P
S
T
Site 115
S1260
S
T
C
P
N
S
P
S
T
P
P
S
T
P
S
Site 116
T1261
T
C
P
N
S
P
S
T
P
P
S
T
P
S
P
Site 117
S1264
N
S
P
S
T
P
P
S
T
P
S
P
R
V
P
Site 118
T1265
S
P
S
T
P
P
S
T
P
S
P
R
V
P
R
Site 119
S1267
S
T
P
P
S
T
P
S
P
R
V
P
R
R
C
Site 120
Y1275
P
R
V
P
R
R
C
Y
V
L
S
S
S
Q
N
Site 121
S1278
P
R
R
C
Y
V
L
S
S
S
Q
N
N
L
A
Site 122
S1280
R
C
Y
V
L
S
S
S
Q
N
N
L
A
H
P
Site 123
S1298
P
V
P
P
R
Q
N
S
S
P
H
L
P
K
L
Site 124
S1299
V
P
P
R
Q
N
S
S
P
H
L
P
K
L
P
Site 125
T1309
L
P
K
L
P
P
K
T
Y
K
R
E
L
S
H
Site 126
Y1310
P
K
L
P
P
K
T
Y
K
R
E
L
S
H
P
Site 127
S1315
K
T
Y
K
R
E
L
S
H
P
P
L
Y
R
L
Site 128
Y1320
E
L
S
H
P
P
L
Y
R
L
P
L
L
E
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation