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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AOX1
Full Name:
Aldehyde oxidase
Alias:
ADO; Aldehyde oxidase 1; AO; AOH1
Type:
Xenobiotic Metabolism - drug metabolism - cytochrome P450; Cofactor and Vitamin Metabolism - vitamin B6; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Amino Acid Metabolism - tryptophan; Oxidoreductase; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 1.2.3.1
Mass (Da):
147899
Number AA:
1338
UniProt ID:
Q06278
International Prot ID:
IPI00029715
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0051537
GO:0050660
GO:0051287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006954
GO:0055114
GO:0006800
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T25
E
K
N
V
D
P
E
T
M
L
L
P
Y
L
R
Site 2
Y30
P
E
T
M
L
L
P
Y
L
R
K
K
L
R
L
Site 3
T38
L
R
K
K
L
R
L
T
G
T
K
Y
G
C
G
Site 4
T40
K
K
L
R
L
T
G
T
K
Y
G
C
G
G
G
Site 5
Y42
L
R
L
T
G
T
K
Y
G
C
G
G
G
G
C
Site 6
Y59
C
T
V
M
I
S
R
Y
N
P
I
T
K
R
I
Site 7
T63
I
S
R
Y
N
P
I
T
K
R
I
R
H
H
P
Site 8
S94
T
T
V
E
G
I
G
S
T
H
T
R
I
H
P
Site 9
T141
E
P
T
L
D
Q
L
T
D
A
L
G
G
N
L
Site 10
T197
E
F
E
E
G
S
K
T
S
P
K
L
F
A
E
Site 11
S198
F
E
E
G
S
K
T
S
P
K
L
F
A
E
E
Site 12
T213
E
F
L
P
L
D
P
T
Q
E
L
I
F
P
P
Site 13
S230
M
I
M
A
E
K
Q
S
Q
R
T
R
V
F
G
Site 14
S245
S
E
R
M
M
W
F
S
P
V
T
L
K
E
L
Site 15
Y259
L
L
E
F
K
F
K
Y
P
Q
A
P
V
I
M
Site 16
T269
A
P
V
I
M
G
N
T
S
V
G
P
E
V
K
Site 17
S270
P
V
I
M
G
N
T
S
V
G
P
E
V
K
F
Site 18
S295
P
D
R
I
E
E
L
S
V
V
N
H
A
Y
N
Site 19
T331
Q
K
L
P
E
E
K
T
Q
M
Y
H
A
L
L
Site 20
Y334
P
E
E
K
T
Q
M
Y
H
A
L
L
K
H
L
Site 21
T343
A
L
L
K
H
L
G
T
L
A
G
S
Q
I
R
Site 22
S347
H
L
G
T
L
A
G
S
Q
I
R
N
M
A
S
Site 23
S361
S
L
G
G
H
I
I
S
R
H
P
D
S
D
L
Site 24
S366
I
I
S
R
H
P
D
S
D
L
N
P
I
L
A
Site 25
S398
P
L
N
E
Q
F
L
S
K
C
P
N
A
D
L
Site 26
S413
K
P
Q
E
I
L
V
S
V
N
I
P
Y
S
R
Site 27
S419
V
S
V
N
I
P
Y
S
R
K
W
E
F
V
S
Site 28
S426
S
R
K
W
E
F
V
S
A
F
R
Q
A
Q
R
Site 29
S506
N
E
V
S
L
L
G
S
A
P
G
G
K
V
E
Site 30
Y527
I
S
F
L
F
K
F
Y
L
E
V
S
Q
I
L
Site 31
S531
F
K
F
Y
L
E
V
S
Q
I
L
K
K
M
D
Site 32
Y542
K
K
M
D
P
V
H
Y
P
S
L
A
D
K
Y
Site 33
S544
M
D
P
V
H
Y
P
S
L
A
D
K
Y
E
S
Site 34
Y549
Y
P
S
L
A
D
K
Y
E
S
A
L
E
D
L
Site 35
S551
S
L
A
D
K
Y
E
S
A
L
E
D
L
H
S
Site 36
S558
S
A
L
E
D
L
H
S
K
H
H
C
S
T
L
Site 37
Y567
H
H
C
S
T
L
K
Y
Q
N
I
G
P
K
Q
Site 38
S588
G
H
P
I
M
H
L
S
G
V
K
H
A
T
G
Site 39
S652
E
H
L
S
D
V
N
S
F
C
F
F
T
E
A
Site 40
Y697
A
K
R
V
K
I
V
Y
Q
D
L
E
P
L
I
Site 41
T706
D
L
E
P
L
I
L
T
I
E
E
S
I
Q
H
Site 42
S716
E
S
I
Q
H
N
S
S
F
K
P
E
R
K
L
Site 43
Y752
M
G
G
Q
E
H
F
Y
M
E
T
Q
S
M
L
Site 44
Y772
E
D
Q
E
M
D
V
Y
V
S
T
Q
F
P
K
Site 45
T775
E
M
D
V
Y
V
S
T
Q
F
P
K
Y
I
Q
Site 46
T845
R
G
E
D
M
L
I
T
G
G
R
H
P
Y
L
Site 47
Y851
I
T
G
G
R
H
P
Y
L
G
K
Y
K
A
G
Site 48
Y855
R
H
P
Y
L
G
K
Y
K
A
G
F
M
N
D
Site 49
Y873
L
A
L
D
M
E
H
Y
S
N
A
G
A
S
L
Site 50
S879
H
Y
S
N
A
G
A
S
L
D
E
S
L
F
V
Site 51
Y898
L
L
K
M
D
N
A
Y
K
F
P
N
L
R
C
Site 52
S916
A
C
R
T
N
L
P
S
N
T
A
F
R
G
F
Site 53
Y956
K
V
R
I
I
N
M
Y
K
E
I
D
Q
T
P
Site 54
T962
M
Y
K
E
I
D
Q
T
P
Y
K
Q
E
I
N
Site 55
S984
W
R
E
C
M
A
M
S
S
Y
S
L
R
K
V
Site 56
Y1001
E
K
F
N
A
E
N
Y
W
K
K
K
G
L
A
Site 57
S1068
R
E
L
R
M
P
M
S
N
V
H
L
R
G
T
Site 58
T1075
S
N
V
H
L
R
G
T
S
T
E
T
V
P
N
Site 59
S1076
N
V
H
L
R
G
T
S
T
E
T
V
P
N
A
Site 60
T1079
L
R
G
T
S
T
E
T
V
P
N
A
N
I
S
Site 61
S1115
K
R
L
E
P
I
I
S
K
N
P
K
G
T
W
Site 62
S1137
F
D
E
S
I
N
L
S
A
V
G
Y
F
R
G
Site 63
Y1141
I
N
L
S
A
V
G
Y
F
R
G
Y
E
S
D
Site 64
Y1145
A
V
G
Y
F
R
G
Y
E
S
D
M
N
W
E
Site 65
Y1161
G
E
G
Q
P
F
E
Y
F
V
Y
G
A
A
C
Site 66
T1177
E
V
E
I
D
C
L
T
G
D
H
K
N
I
R
Site 67
Y1222
Y
T
I
E
E
L
N
Y
S
P
Q
G
I
L
H
Site 68
S1223
T
I
E
E
L
N
Y
S
P
Q
G
I
L
H
T
Site 69
Y1236
H
T
R
G
P
D
Q
Y
K
I
P
A
I
C
D
Site 70
S1256
H
I
A
L
L
P
P
S
Q
N
S
N
T
L
Y
Site 71
S1259
L
L
P
P
S
Q
N
S
N
T
L
Y
S
S
K
Site 72
T1261
P
P
S
Q
N
S
N
T
L
Y
S
S
K
G
L
Site 73
Y1263
S
Q
N
S
N
T
L
Y
S
S
K
G
L
G
E
Site 74
S1288
F
A
I
H
D
A
V
S
A
A
R
Q
E
R
G
Site 75
T1301
R
G
L
H
G
P
L
T
L
N
S
P
L
T
P
Site 76
S1304
H
G
P
L
T
L
N
S
P
L
T
P
E
K
I
Site 77
T1307
L
T
L
N
S
P
L
T
P
E
K
I
R
M
A
Site 78
S1330
I
P
R
D
E
P
G
S
Y
V
P
W
N
V
P
Site 79
Y1331
P
R
D
E
P
G
S
Y
V
P
W
N
V
P
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation