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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LRRC63
Full Name:
Leucine-rich repeat-containing protein 63
Alias:
Type:
Mass (Da):
66309
Number AA:
580
UniProt ID:
Q05C16
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
P
P
K
F
T
K
L
S
L
H
E
K
K
T
H
Site 2
T26
L
S
L
H
E
K
K
T
H
T
A
K
T
G
K
Site 3
T31
K
K
T
H
T
A
K
T
G
K
I
E
S
L
H
Site 4
S36
A
K
T
G
K
I
E
S
L
H
V
A
F
T
E
Site 5
T42
E
S
L
H
V
A
F
T
E
D
E
T
T
S
I
Site 6
T46
V
A
F
T
E
D
E
T
T
S
I
K
M
D
R
Site 7
T47
A
F
T
E
D
E
T
T
S
I
K
M
D
R
T
Site 8
T54
T
S
I
K
M
D
R
T
R
F
P
D
V
L
R
Site 9
S64
P
D
V
L
R
N
Q
S
L
T
P
I
N
I
Q
Site 10
T66
V
L
R
N
Q
S
L
T
P
I
N
I
Q
N
I
Site 11
T84
H
C
V
Q
E
R
V
T
A
I
S
S
P
Q
K
Site 12
S87
Q
E
R
V
T
A
I
S
S
P
Q
K
S
T
K
Site 13
S88
E
R
V
T
A
I
S
S
P
Q
K
S
T
K
H
Site 14
S92
A
I
S
S
P
Q
K
S
T
K
H
V
R
E
Q
Site 15
T105
E
Q
I
P
D
T
A
T
G
S
I
F
F
P
H
Site 16
S130
K
Q
T
N
K
M
E
S
S
R
K
F
K
T
M
Site 17
T136
E
S
S
R
K
F
K
T
M
K
D
V
Y
T
E
Site 18
Y141
F
K
T
M
K
D
V
Y
T
E
K
R
L
E
N
Site 19
T142
K
T
M
K
D
V
Y
T
E
K
R
L
E
N
I
Site 20
S153
L
E
N
I
L
I
L
S
S
K
F
S
K
P
K
Site 21
S154
E
N
I
L
I
L
S
S
K
F
S
K
P
K
S
Site 22
S157
L
I
L
S
S
K
F
S
K
P
K
S
T
P
G
Site 23
S161
S
K
F
S
K
P
K
S
T
P
G
S
V
I
A
Site 24
T162
K
F
S
K
P
K
S
T
P
G
S
V
I
A
Q
Site 25
S165
K
P
K
S
T
P
G
S
V
I
A
Q
K
L
E
Site 26
S184
K
H
Q
P
L
P
E
S
P
G
Y
T
Y
Q
H
Site 27
Y187
P
L
P
E
S
P
G
Y
T
Y
Q
H
I
S
R
Site 28
T188
L
P
E
S
P
G
Y
T
Y
Q
H
I
S
R
D
Site 29
Y189
P
E
S
P
G
Y
T
Y
Q
H
I
S
R
D
L
Site 30
S197
Q
H
I
S
R
D
L
S
A
T
V
P
S
P
P
Site 31
T199
I
S
R
D
L
S
A
T
V
P
S
P
P
P
M
Site 32
S202
D
L
S
A
T
V
P
S
P
P
P
M
T
V
S
Site 33
T207
V
P
S
P
P
P
M
T
V
S
M
K
P
E
G
Site 34
S209
S
P
P
P
M
T
V
S
M
K
P
E
G
Q
W
Site 35
S222
Q
W
P
E
H
F
K
S
T
A
T
L
T
L
R
Site 36
T241
P
G
F
V
S
L
P
T
P
V
L
P
R
K
P
Site 37
S252
P
R
K
P
H
R
Q
S
V
I
E
T
L
V
T
Site 38
T256
H
R
Q
S
V
I
E
T
L
V
T
E
N
G
N
Site 39
T259
S
V
I
E
T
L
V
T
E
N
G
N
I
E
S
Site 40
S266
T
E
N
G
N
I
E
S
V
P
K
Q
I
P
P
Site 41
T282
P
P
E
G
L
T
K
T
E
K
I
E
S
E
I
Site 42
S287
T
K
T
E
K
I
E
S
E
I
H
V
V
R
G
Site 43
T299
V
R
G
E
G
F
K
T
V
A
A
T
R
Y
E
Site 44
S422
Y
L
E
E
L
D
V
S
Y
N
E
L
T
F
I
Site 45
Y423
L
E
E
L
D
V
S
Y
N
E
L
T
F
I
P
Site 46
T427
D
V
S
Y
N
E
L
T
F
I
P
N
E
I
Q
Site 47
T443
L
R
S
L
E
K
L
T
V
D
G
N
E
L
S
Site 48
T462
G
I
L
K
L
N
L
T
K
I
Q
F
E
N
N
Site 49
Y480
P
C
F
W
R
D
N
Y
L
N
N
P
Q
Q
L
Site 50
S529
L
T
E
L
A
P
L
S
I
Y
S
S
R
K
A
Site 51
Y531
E
L
A
P
L
S
I
Y
S
S
R
K
A
I
T
Site 52
S532
L
A
P
L
S
I
Y
S
S
R
K
A
I
T
E
Site 53
S533
A
P
L
S
I
Y
S
S
R
K
A
I
T
E
G
Site 54
Y541
R
K
A
I
T
E
G
Y
I
A
V
E
L
P
K
Site 55
T561
N
I
T
E
G
L
L
T
Q
K
R
Y
E
E
V
Site 56
Y565
G
L
L
T
Q
K
R
Y
E
E
V
M
V
K
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation