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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EML5
Full Name:
Echinoderm microtubule-associated protein-like 5
Alias:
echinoderm microtubule associated like 5; echinoderm microtubule associated protein like 5; EMAL5; EMAP-2; HuEMAP-2
Type:
Unknown function
Mass (Da):
219370
Number AA:
UniProt ID:
Q05BV3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005874
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y29
H
Q
C
R
N
N
L
Y
Y
T
A
A
K
E
I
Site 2
Y30
Q
C
R
N
N
L
Y
Y
T
A
A
K
E
I
V
Site 3
S48
A
G
V
G
V
V
Y
S
P
R
E
H
R
Q
K
Site 4
S61
Q
K
F
Y
R
G
H
S
D
D
I
I
S
L
A
Site 5
S66
G
H
S
D
D
I
I
S
L
A
L
H
P
E
R
Site 6
T78
P
E
R
V
L
V
A
T
G
Q
V
G
K
E
P
Site 7
Y86
G
Q
V
G
K
E
P
Y
I
C
I
W
D
S
Y
Site 8
S123
L
D
G
Q
R
L
V
S
V
G
L
D
S
K
N
Site 9
S144
W
K
R
G
K
M
L
S
M
A
P
G
H
T
D
Site 10
T150
L
S
M
A
P
G
H
T
D
R
I
F
D
I
S
Site 11
Y161
F
D
I
S
W
D
L
Y
Q
P
N
K
L
V
S
Site 12
T211
A
C
A
R
D
E
L
T
Y
S
G
A
L
N
G
Site 13
Y212
C
A
R
D
E
L
T
Y
S
G
A
L
N
G
D
Site 14
S213
A
R
D
E
L
T
Y
S
G
A
L
N
G
D
I
Site 15
T252
A
C
E
E
G
F
A
T
G
G
R
D
G
C
I
Site 16
T277
T
V
I
D
L
R
E
T
D
Q
G
Y
K
G
L
Site 17
Y281
L
R
E
T
D
Q
G
Y
K
G
L
S
V
R
S
Site 18
S285
D
Q
G
Y
K
G
L
S
V
R
S
V
C
W
R
Site 19
S344
K
P
L
A
V
T
G
S
D
D
R
S
V
R
I
Site 20
S348
V
T
G
S
D
D
R
S
V
R
I
W
S
L
V
Site 21
T399
V
L
R
V
R
D
M
T
E
V
V
H
I
K
D
Site 22
Y416
E
A
I
H
E
L
K
Y
S
P
D
G
T
Y
L
Site 23
S417
A
I
H
E
L
K
Y
S
P
D
G
T
Y
L
A
Site 24
T421
L
K
Y
S
P
D
G
T
Y
L
A
V
G
C
N
Site 25
Y422
K
Y
S
P
D
G
T
Y
L
A
V
G
C
N
D
Site 26
Y435
N
D
S
S
V
D
I
Y
G
V
A
Q
R
Y
K
Site 27
Y441
I
Y
G
V
A
Q
R
Y
K
K
V
G
E
C
L
Site 28
T455
L
G
S
L
S
F
I
T
H
L
D
W
S
S
D
Site 29
S461
I
T
H
L
D
W
S
S
D
S
R
Y
L
Q
T
Site 30
S463
H
L
D
W
S
S
D
S
R
Y
L
Q
T
N
D
Site 31
Y465
D
W
S
S
D
S
R
Y
L
Q
T
N
D
G
N
Site 32
Y478
G
N
G
K
R
L
F
Y
R
M
P
G
G
K
E
Site 33
S488
P
G
G
K
E
V
T
S
T
E
E
I
K
G
V
Site 34
T489
G
G
K
E
V
T
S
T
E
E
I
K
G
V
H
Site 35
Y515
V
N
G
I
W
P
K
Y
S
D
I
N
D
I
N
Site 36
S523
S
D
I
N
D
I
N
S
V
D
G
N
Y
I
G
Site 37
Y559
K
G
A
K
F
R
K
Y
I
G
H
S
A
H
V
Site 38
T567
I
G
H
S
A
H
V
T
N
V
R
W
S
H
D
Site 39
S610
V
H
I
A
P
Q
E
S
L
A
D
S
H
S
D
Site 40
S614
P
Q
E
S
L
A
D
S
H
S
D
E
S
D
S
Site 41
S616
E
S
L
A
D
S
H
S
D
E
S
D
S
D
L
Site 42
S619
A
D
S
H
S
D
E
S
D
S
D
L
S
D
V
Site 43
S621
S
H
S
D
E
S
D
S
D
L
S
D
V
P
E
Site 44
S624
D
E
S
D
S
D
L
S
D
V
P
E
L
D
S
Site 45
S631
S
D
V
P
E
L
D
S
E
I
E
Q
E
T
Q
Site 46
T640
I
E
Q
E
T
Q
L
T
Y
R
R
Q
V
Y
K
Site 47
Y646
L
T
Y
R
R
Q
V
Y
K
E
D
L
P
Q
L
Site 48
S663
Q
C
K
E
K
Q
K
S
A
T
S
K
R
R
E
Site 49
S666
E
K
Q
K
S
A
T
S
K
R
R
E
R
A
P
Site 50
S676
R
E
R
A
P
G
N
S
I
R
L
H
F
V
H
Site 51
Y688
F
V
H
G
Y
R
G
Y
D
C
R
S
N
L
F
Site 52
Y696
D
C
R
S
N
L
F
Y
T
Q
I
G
E
I
V
Site 53
Y713
V
A
A
V
G
V
I
Y
N
R
Q
Q
N
T
Q
Site 54
Y723
Q
Q
N
T
Q
R
F
Y
L
G
H
D
D
D
I
Site 55
T734
D
D
D
I
L
C
L
T
I
H
P
L
K
D
Y
Site 56
Y741
T
I
H
P
L
K
D
Y
V
A
T
G
Q
V
G
Site 57
S752
G
Q
V
G
R
D
P
S
I
H
I
W
D
T
E
Site 58
T758
P
S
I
H
I
W
D
T
E
T
I
K
P
L
S
Site 59
S765
T
E
T
I
K
P
L
S
I
L
K
G
H
H
Q
Site 60
S776
G
H
H
Q
Y
G
V
S
A
V
D
F
S
A
D
Site 61
S789
A
D
G
K
R
L
A
S
V
G
I
D
D
S
H
Site 62
S810
W
K
K
G
E
K
L
S
I
A
R
G
S
K
D
Site 63
Y856
G
L
I
G
R
K
G
Y
I
G
T
L
G
K
N
Site 64
S880
W
T
E
E
M
A
F
S
G
T
S
T
G
D
V
Site 65
T898
R
D
I
F
L
V
K
T
V
K
A
H
D
G
P
Site 66
S908
A
H
D
G
P
V
F
S
M
H
A
L
E
K
G
Site 67
T938
S
F
E
R
C
L
K
T
Y
A
I
K
R
A
A
Site 68
Y939
F
E
R
C
L
K
T
Y
A
I
K
R
A
A
L
Site 69
S965
N
P
S
I
R
A
I
S
L
G
H
G
H
I
L
Site 70
T1021
A
T
V
S
D
D
K
T
L
R
I
W
D
L
S
Site 71
S1077
D
T
L
E
D
L
V
S
F
H
H
R
K
D
M
Site 72
S1086
H
H
R
K
D
M
I
S
D
I
R
F
S
P
G
Site 73
S1091
M
I
S
D
I
R
F
S
P
G
S
G
K
Y
L
Site 74
S1094
D
I
R
F
S
P
G
S
G
K
Y
L
A
V
A
Site 75
Y1097
F
S
P
G
S
G
K
Y
L
A
V
A
S
H
D
Site 76
Y1110
H
D
S
F
I
D
I
Y
N
V
M
S
S
K
R
Site 77
T1161
A
P
R
G
K
K
Q
T
I
P
S
V
E
V
E
Site 78
S1164
G
K
K
Q
T
I
P
S
V
E
V
E
K
I
A
Site 79
S1199
E
V
T
D
V
T
A
S
C
L
T
S
D
K
M
Site 80
Y1222
G
F
V
K
L
F
R
Y
P
T
K
G
K
F
G
Site 81
T1224
V
K
L
F
R
Y
P
T
K
G
K
F
G
K
F
Site 82
Y1234
K
F
G
K
F
K
R
Y
V
A
H
S
T
H
V
Site 83
Y1248
V
T
N
V
R
W
T
Y
D
D
S
M
L
V
T
Site 84
S1251
V
R
W
T
Y
D
D
S
M
L
V
T
L
G
G
Site 85
T1255
Y
D
D
S
M
L
V
T
L
G
G
T
D
M
S
Site 86
Y1273
W
T
N
E
M
E
G
Y
R
E
K
R
P
C
D
Site 87
S1281
R
E
K
R
P
C
D
S
E
E
S
D
I
D
S
Site 88
S1284
R
P
C
D
S
E
E
S
D
I
D
S
E
E
D
Site 89
S1288
S
E
E
S
D
I
D
S
E
E
D
G
G
Y
D
Site 90
Y1294
D
S
E
E
D
G
G
Y
D
S
D
V
T
R
E
Site 91
S1296
E
E
D
G
G
Y
D
S
D
V
T
R
E
N
E
Site 92
T1299
G
G
Y
D
S
D
V
T
R
E
N
E
I
S
Y
Site 93
S1305
V
T
R
E
N
E
I
S
Y
T
I
R
A
L
S
Site 94
Y1306
T
R
E
N
E
I
S
Y
T
I
R
A
L
S
T
Site 95
T1307
R
E
N
E
I
S
Y
T
I
R
A
L
S
T
N
Site 96
S1312
S
Y
T
I
R
A
L
S
T
N
I
R
P
M
L
Site 97
S1331
H
L
Q
Q
K
E
P
S
I
D
E
R
P
P
V
Site 98
S1339
I
D
E
R
P
P
V
S
R
A
P
P
Q
P
E
Site 99
T1350
P
Q
P
E
K
L
Q
T
N
N
V
G
K
K
K
Site 100
Y1382
D
C
R
N
N
V
H
Y
L
N
D
G
D
D
I
Site 101
Y1391
N
D
G
D
D
I
I
Y
H
T
A
S
V
G
I
Site 102
T1404
G
I
L
H
N
V
A
T
G
S
Q
S
F
Y
Q
Site 103
S1406
L
H
N
V
A
T
G
S
Q
S
F
Y
Q
E
H
Site 104
S1408
N
V
A
T
G
S
Q
S
F
Y
Q
E
H
N
D
Site 105
Y1410
A
T
G
S
Q
S
F
Y
Q
E
H
N
D
D
I
Site 106
S1440
A
T
G
Q
V
G
D
S
A
D
M
S
A
T
A
Site 107
S1444
V
G
D
S
A
D
M
S
A
T
A
P
S
I
H
Site 108
S1474
Y
H
S
K
G
V
C
S
V
S
F
S
A
T
G
Site 109
S1525
V
A
E
F
R
P
D
S
D
T
Q
F
V
S
V
Site 110
T1527
E
F
R
P
D
S
D
T
Q
F
V
S
V
G
V
Site 111
S1531
D
S
D
T
Q
F
V
S
V
G
V
K
H
V
K
Site 112
T1556
S
K
K
G
L
L
S
T
L
E
D
A
R
M
Q
Site 113
S1626
T
G
G
K
E
R
P
S
K
E
G
G
A
V
K
Site 114
T1649
C
R
A
F
R
L
E
T
G
Q
A
T
D
C
V
Site 115
T1653
R
L
E
T
G
Q
A
T
D
C
V
R
S
V
C
Site 116
S1658
Q
A
T
D
C
V
R
S
V
C
R
G
K
G
K
Site 117
S1705
W
G
L
A
T
H
P
S
R
D
F
F
L
S
A
Site 118
S1711
P
S
R
D
F
F
L
S
A
A
E
D
G
T
V
Site 119
T1740
N
L
G
H
A
A
R
T
V
C
Y
S
P
E
G
Site 120
S1786
A
I
H
D
I
R
F
S
P
D
S
R
Y
L
A
Site 121
S1789
D
I
R
F
S
P
D
S
R
Y
L
A
V
G
S
Site 122
Y1791
R
F
S
P
D
S
R
Y
L
A
V
G
S
S
E
Site 123
S1796
S
R
Y
L
A
V
G
S
S
E
N
S
V
D
F
Site 124
S1800
A
V
G
S
S
E
N
S
V
D
F
Y
D
L
T
Site 125
Y1804
S
E
N
S
V
D
F
Y
D
L
T
L
G
P
T
Site 126
T1807
S
V
D
F
Y
D
L
T
L
G
P
T
L
N
R
Site 127
T1811
Y
D
L
T
L
G
P
T
L
N
R
I
S
Y
C
Site 128
S1816
G
P
T
L
N
R
I
S
Y
C
K
D
I
P
S
Site 129
Y1817
P
T
L
N
R
I
S
Y
C
K
D
I
P
S
F
Site 130
S1834
Q
M
D
F
S
A
D
S
S
Y
L
Q
V
S
S
Site 131
S1835
M
D
F
S
A
D
S
S
Y
L
Q
V
S
S
G
Site 132
Y1836
D
F
S
A
D
S
S
Y
L
Q
V
S
S
G
C
Site 133
S1841
S
S
Y
L
Q
V
S
S
G
C
Y
K
R
H
V
Site 134
Y1844
L
Q
V
S
S
G
C
Y
K
R
H
V
Y
E
V
Site 135
Y1849
G
C
Y
K
R
H
V
Y
E
V
P
S
G
K
H
Site 136
S1934
H
K
R
F
L
G
H
S
P
H
V
T
N
I
R
Site 137
T1938
L
G
H
S
P
H
V
T
N
I
R
F
T
S
G
Site 138
T1943
H
V
T
N
I
R
F
T
S
G
D
R
H
V
V
Site 139
S1944
V
T
N
I
R
F
T
S
G
D
R
H
V
V
S
Site 140
S1951
S
G
D
R
H
V
V
S
A
G
G
D
D
C
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation