PhosphoNET

           
Protein Info 
   
Short Name:  EN1
Full Name:  Homeobox protein engrailed-1
Alias:  Hu-En-1
Type:  Nucleus protein
Mass (Da):  40115
Number AA:  392
UniProt ID:  Q05925
International Prot ID:  IPI00016734
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005634     Uniprot OncoNet
Molecular Function:  GO:0043565  GO:0003700   PhosphoSite+ KinaseNET
Biological Process:  GO:0006355  GO:0001501   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S10EQQPEPKSQRDSALG
Site 2S14EPKSQRDSALGAAAA
Site 3S32GGLSLSLSPGASGSS
Site 4S36LSLSPGASGSSGSGS
Site 5S38LSPGASGSSGSGSDG
Site 6S39SPGASGSSGSGSDGD
Site 7S41GASGSSGSGSDGDSV
Site 8S43SGSSGSGSDGDSVPV
Site 9S47GSGSDGDSVPVSPQP
Site 10S51DGDSVPVSPQPAPPS
Site 11S58SPQPAPPSPPAAPCL
Site 12T149VERDRGQTAAGRDPV
Site 13S183NCGPPDGSQPAAAGA
Site 14S221AAAAAKPSDTGGGGS
Site 15T223AAAKPSDTGGGGSGG
Site 16S228SDTGGGGSGGGAGSP
Site 17S234GSGGGAGSPGAQGTK
Site 18T240GSPGAQGTKYPEHGN
Site 19Y242PGAQGTKYPEHGNPA
Site 20T264NGGPVVKTDSQQPLV
Site 21S266GPVVKTDSQQPLVWP
Site 22Y281AWVYCTRYSDRPSSG
Site 23S282WVYCTRYSDRPSSGP
Site 24S286TRYSDRPSSGPRTRK
Site 25S287RYSDRPSSGPRTRKL
Site 26T291RPSSGPRTRKLKKKK
Site 27T308KEDKRPRTAFTAEQL
Site 28T329FQANRYITEQRRQTL
Site 29T335ITEQRRQTLAQELSL
Site 30S341QTLAQELSLNESQIK
Site 31S345QELSLNESQIKIWFQ
Site 32T382QGLYNHSTTTVQDKD
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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