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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ICA1
Full Name:
Islet cell autoantigen 1
Alias:
69 kDa islet cell autoantigen; ICA69; ICAp69; Islet cell autoantigen p69
Type:
Uncharacterized, may be involved in neurotransmitter release
Mass (Da):
54645
Number AA:
483
UniProt ID:
Q05084
International Prot ID:
IPI00011606
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000139
GO:0030054
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006836
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
P
W
D
L
Q
D
R
Y
A
Q
D
K
S
V
V
Site 2
S21
D
R
Y
A
Q
D
K
S
V
V
N
K
M
Q
Q
Site 3
Y30
V
N
K
M
Q
Q
K
Y
W
E
T
K
Q
A
F
Site 4
S52
E
D
E
H
V
V
A
S
D
A
D
L
D
A
K
Site 5
S65
A
K
L
E
L
F
H
S
I
Q
R
T
C
L
D
Site 6
T69
L
F
H
S
I
Q
R
T
C
L
D
L
S
K
A
Site 7
S88
Q
K
R
I
C
F
L
S
Q
E
E
N
E
L
G
Site 8
S100
E
L
G
K
F
L
R
S
Q
G
F
Q
D
K
T
Site 9
T107
S
Q
G
F
Q
D
K
T
R
A
G
K
M
M
Q
Site 10
T116
A
G
K
M
M
Q
A
T
G
K
A
L
C
F
S
Site 11
S124
G
K
A
L
C
F
S
S
Q
Q
R
L
A
L
R
Site 12
T143
R
F
H
Q
E
V
E
T
F
R
H
R
A
I
S
Site 13
S150
T
F
R
H
R
A
I
S
D
T
W
L
T
V
N
Site 14
T155
A
I
S
D
T
W
L
T
V
N
R
M
E
Q
C
Site 15
T164
N
R
M
E
Q
C
R
T
E
Y
R
G
A
L
L
Site 16
Y166
M
E
Q
C
R
T
E
Y
R
G
A
L
L
W
M
Site 17
S177
L
L
W
M
K
D
V
S
Q
E
L
D
P
D
L
Site 18
Y185
Q
E
L
D
P
D
L
Y
K
Q
M
E
K
F
R
Site 19
S228
A
S
R
C
N
L
L
S
H
M
L
A
T
Y
Q
Site 20
Y259
I
H
E
S
F
K
G
Y
Q
P
Y
E
F
T
T
Site 21
Y262
S
F
K
G
Y
Q
P
Y
E
F
T
T
L
K
S
Site 22
T265
G
Y
Q
P
Y
E
F
T
T
L
K
S
L
Q
D
Site 23
S269
Y
E
F
T
T
L
K
S
L
Q
D
P
M
K
K
Site 24
S300
D
A
A
V
Q
E
P
S
Q
L
I
S
L
E
E
Site 25
S304
Q
E
P
S
Q
L
I
S
L
E
E
E
N
Q
R
Site 26
S314
E
E
N
Q
R
K
E
S
S
S
F
K
T
E
D
Site 27
S316
N
Q
R
K
E
S
S
S
F
K
T
E
D
G
K
Site 28
T319
K
E
S
S
S
F
K
T
E
D
G
K
S
I
L
Site 29
S324
F
K
T
E
D
G
K
S
I
L
S
A
L
D
K
Site 30
S327
E
D
G
K
S
I
L
S
A
L
D
K
G
S
T
Site 31
S333
L
S
A
L
D
K
G
S
T
H
T
A
C
S
G
Site 32
T336
L
D
K
G
S
T
H
T
A
C
S
G
P
I
D
Site 33
S350
D
E
L
L
D
M
K
S
E
E
G
A
C
L
G
Site 34
T362
C
L
G
P
V
A
G
T
P
E
P
E
G
A
D
Site 35
S384
S
E
I
F
N
A
S
S
L
E
E
G
E
F
S
Site 36
S391
S
L
E
E
G
E
F
S
K
E
W
A
A
V
F
Site 37
T409
Q
V
K
E
P
V
P
T
M
A
L
G
E
P
D
Site 38
T421
E
P
D
P
K
A
Q
T
G
S
G
F
L
P
S
Site 39
S428
T
G
S
G
F
L
P
S
Q
L
L
D
Q
N
M
Site 40
S466
F
A
D
L
D
P
L
S
N
P
D
A
V
G
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation