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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CHRNE
Full Name:
Acetylcholine receptor subunit epsilon
Alias:
Type:
Mass (Da):
54697
Number AA:
493
UniProt ID:
Q04844
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y28
K
N
E
E
L
R
L
Y
H
H
L
F
N
N
Y
Site 2
Y35
Y
H
H
L
F
N
N
Y
D
P
G
S
R
P
V
Site 3
S39
F
N
N
Y
D
P
G
S
R
P
V
R
E
P
E
Site 4
T48
P
V
R
E
P
E
D
T
V
T
I
S
L
K
V
Site 5
T50
R
E
P
E
D
T
V
T
I
S
L
K
V
T
L
Site 6
S52
P
E
D
T
V
T
I
S
L
K
V
T
L
T
N
Site 7
S62
V
T
L
T
N
L
I
S
L
N
E
K
E
E
T
Site 8
T69
S
L
N
E
K
E
E
T
L
T
T
S
V
W
I
Site 9
T71
N
E
K
E
E
T
L
T
T
S
V
W
I
G
I
Site 10
T72
E
K
E
E
T
L
T
T
S
V
W
I
G
I
D
Site 11
Y83
I
G
I
D
W
Q
D
Y
R
L
N
Y
S
K
D
Site 12
Y87
W
Q
D
Y
R
L
N
Y
S
K
D
D
F
G
G
Site 13
S88
Q
D
Y
R
L
N
Y
S
K
D
D
F
G
G
I
Site 14
T97
D
D
F
G
G
I
E
T
L
R
V
P
S
E
L
Site 15
S168
N
C
S
L
I
F
R
S
Q
T
Y
N
A
E
E
Site 16
T170
S
L
I
F
R
S
Q
T
Y
N
A
E
E
V
E
Site 17
T179
N
A
E
E
V
E
F
T
F
A
V
D
N
D
G
Site 18
T188
A
V
D
N
D
G
K
T
I
N
K
I
D
I
D
Site 19
T196
I
N
K
I
D
I
D
T
E
A
Y
T
E
N
G
Site 20
Y199
I
D
I
D
T
E
A
Y
T
E
N
G
E
W
A
Site 21
T222
R
R
H
H
G
G
A
T
D
G
P
G
E
T
D
Site 22
Y232
P
G
E
T
D
V
I
Y
S
L
I
I
R
R
K
Site 23
S233
G
E
T
D
V
I
Y
S
L
I
I
R
R
K
P
Site 24
T332
V
L
N
V
S
Q
R
T
P
T
T
H
A
M
S
Site 25
T334
N
V
S
Q
R
T
P
T
T
H
A
M
S
P
R
Site 26
T335
V
S
Q
R
T
P
T
T
H
A
M
S
P
R
L
Site 27
S339
T
P
T
T
H
A
M
S
P
R
L
R
H
V
L
Site 28
S356
L
L
P
R
L
L
G
S
P
P
P
P
E
A
P
Site 29
S367
P
E
A
P
R
A
A
S
P
P
R
R
A
S
S
Site 30
S373
A
S
P
P
R
R
A
S
S
V
G
L
L
L
R
Site 31
S374
S
P
P
R
R
A
S
S
V
G
L
L
L
R
A
Site 32
S391
L
I
L
K
K
P
R
S
E
L
V
F
E
G
Q
Site 33
S433
A
V
N
F
V
A
E
S
T
R
D
Q
E
A
T
Site 34
T440
S
T
R
D
Q
E
A
T
G
E
E
V
S
D
W
Site 35
S445
E
A
T
G
E
E
V
S
D
W
V
R
M
G
N
Site 36
Y487
N
R
V
P
D
L
P
Y
A
P
C
I
Q
P
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation