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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BCE1
Full Name:
Transducin-like enhancer protein 4
Alias:
BCE-1; Grg-4; Groucho-related protein 4; TLE4
Type:
Nucleus protein
Mass (Da):
83755
Number AA:
773
UniProt ID:
Q04727
International Prot ID:
IPI00749371
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
I
R
D
L
S
K
M
Y
P
Q
T
R
H
P
A
Site 2
T12
L
S
K
M
Y
P
Q
T
R
H
P
A
P
H
Q
Site 3
T27
P
A
Q
P
F
K
F
T
I
S
E
S
C
D
R
Site 4
S31
F
K
F
T
I
S
E
S
C
D
R
I
K
E
E
Site 5
S58
L
E
C
E
K
L
A
S
E
K
T
E
M
Q
R
Site 6
T61
E
K
L
A
S
E
K
T
E
M
Q
R
H
Y
V
Site 7
Y67
K
T
E
M
Q
R
H
Y
V
M
Y
Y
E
M
S
Site 8
Y70
M
Q
R
H
Y
V
M
Y
Y
E
M
S
Y
G
L
Site 9
Y71
Q
R
H
Y
V
M
Y
Y
E
M
S
Y
G
L
N
Site 10
S103
A
Q
V
I
P
F
L
S
Q
E
H
Q
Q
Q
V
Site 11
T149
H
G
L
P
V
P
L
T
P
H
P
S
G
L
Q
Site 12
S201
D
H
Q
R
D
R
D
S
I
K
S
S
S
V
S
Site 13
S204
R
D
R
D
S
I
K
S
S
S
V
S
P
S
A
Site 14
S205
D
R
D
S
I
K
S
S
S
V
S
P
S
A
S
Site 15
S206
R
D
S
I
K
S
S
S
V
S
P
S
A
S
F
Site 16
S208
S
I
K
S
S
S
V
S
P
S
A
S
F
R
G
Site 17
S210
K
S
S
S
V
S
P
S
A
S
F
R
G
A
E
Site 18
S212
S
S
V
S
P
S
A
S
F
R
G
A
E
K
H
Site 19
S222
G
A
E
K
H
R
N
S
A
D
Y
S
S
E
S
Site 20
Y225
K
H
R
N
S
A
D
Y
S
S
E
S
K
K
Q
Site 21
S226
H
R
N
S
A
D
Y
S
S
E
S
K
K
Q
K
Site 22
S227
R
N
S
A
D
Y
S
S
E
S
K
K
Q
K
T
Site 23
T234
S
E
S
K
K
Q
K
T
E
E
K
E
I
A
A
Site 24
Y243
E
K
E
I
A
A
R
Y
D
S
D
G
E
K
S
Site 25
S245
E
I
A
A
R
Y
D
S
D
G
E
K
S
D
D
Site 26
S250
Y
D
S
D
G
E
K
S
D
D
N
L
V
V
D
Site 27
S259
D
N
L
V
V
D
V
S
N
E
D
P
S
S
P
Site 28
S264
D
V
S
N
E
D
P
S
S
P
R
G
S
P
A
Site 29
S265
V
S
N
E
D
P
S
S
P
R
G
S
P
A
H
Site 30
S269
D
P
S
S
P
R
G
S
P
A
H
S
P
R
E
Site 31
S273
P
R
G
S
P
A
H
S
P
R
E
N
G
L
D
Site 32
T282
R
E
N
G
L
D
K
T
R
L
L
K
K
D
A
Site 33
S292
L
K
K
D
A
P
I
S
P
A
S
I
A
S
S
Site 34
S295
D
A
P
I
S
P
A
S
I
A
S
S
S
S
T
Site 35
S298
I
S
P
A
S
I
A
S
S
S
S
T
P
S
S
Site 36
S299
S
P
A
S
I
A
S
S
S
S
T
P
S
S
K
Site 37
S300
P
A
S
I
A
S
S
S
S
T
P
S
S
K
S
Site 38
S301
A
S
I
A
S
S
S
S
T
P
S
S
K
S
K
Site 39
T302
S
I
A
S
S
S
S
T
P
S
S
K
S
K
E
Site 40
S304
A
S
S
S
S
T
P
S
S
K
S
K
E
L
S
Site 41
S305
S
S
S
S
T
P
S
S
K
S
K
E
L
S
L
Site 42
S307
S
S
T
P
S
S
K
S
K
E
L
S
L
N
E
Site 43
S311
S
S
K
S
K
E
L
S
L
N
E
K
S
T
T
Site 44
S316
E
L
S
L
N
E
K
S
T
T
P
V
S
K
S
Site 45
T317
L
S
L
N
E
K
S
T
T
P
V
S
K
S
N
Site 46
T318
S
L
N
E
K
S
T
T
P
V
S
K
S
N
T
Site 47
S321
E
K
S
T
T
P
V
S
K
S
N
T
P
T
P
Site 48
S323
S
T
T
P
V
S
K
S
N
T
P
T
P
R
T
Site 49
T325
T
P
V
S
K
S
N
T
P
T
P
R
T
D
A
Site 50
T327
V
S
K
S
N
T
P
T
P
R
T
D
A
P
T
Site 51
T330
S
N
T
P
T
P
R
T
D
A
P
T
P
G
S
Site 52
T334
T
P
R
T
D
A
P
T
P
G
S
N
S
T
P
Site 53
S337
T
D
A
P
T
P
G
S
N
S
T
P
G
L
R
Site 54
S339
A
P
T
P
G
S
N
S
T
P
G
L
R
P
V
Site 55
T340
P
T
P
G
S
N
S
T
P
G
L
R
P
V
P
Site 56
S358
P
G
V
D
P
L
A
S
S
L
R
T
P
M
A
Site 57
T387
A
G
M
N
G
E
L
T
S
P
G
A
A
Y
A
Site 58
S388
G
M
N
G
E
L
T
S
P
G
A
A
Y
A
G
Site 59
T440
P
A
I
P
P
N
L
T
G
I
P
G
G
K
P
Site 60
Y449
I
P
G
G
K
P
A
Y
S
F
H
V
S
A
D
Site 61
S450
P
G
G
K
P
A
Y
S
F
H
V
S
A
D
G
Site 62
S454
P
A
Y
S
F
H
V
S
A
D
G
Q
M
Q
P
Site 63
Y503
S
N
P
T
R
H
V
Y
T
G
G
K
G
C
V
Site 64
S522
I
S
H
P
G
N
K
S
P
V
S
Q
L
D
C
Site 65
S525
P
G
N
K
S
P
V
S
Q
L
D
C
L
N
R
Site 66
Y535
D
C
L
N
R
D
N
Y
I
R
S
C
R
L
L
Site 67
S538
N
R
D
N
Y
I
R
S
C
R
L
L
P
D
G
Site 68
T574
P
R
I
K
A
E
L
T
S
S
A
P
A
C
Y
Site 69
S623
Q
G
H
T
D
G
A
S
C
I
D
I
S
N
D
Site 70
T632
I
D
I
S
N
D
G
T
K
L
W
T
G
G
L
Site 71
T642
W
T
G
G
L
D
N
T
V
R
S
W
D
L
R
Site 72
T660
Q
L
Q
Q
H
D
F
T
S
Q
I
F
S
L
G
Site 73
S661
L
Q
Q
H
D
F
T
S
Q
I
F
S
L
G
Y
Site 74
Y695
H
V
T
K
P
D
K
Y
Q
L
H
L
H
E
S
Site 75
S702
Y
Q
L
H
L
H
E
S
C
V
L
S
L
K
F
Site 76
S706
L
H
E
S
C
V
L
S
L
K
F
A
H
C
G
Site 77
T730
N
L
L
N
A
W
R
T
P
Y
G
A
S
I
F
Site 78
Y732
L
N
A
W
R
T
P
Y
G
A
S
I
F
Q
S
Site 79
S735
W
R
T
P
Y
G
A
S
I
F
Q
S
K
E
S
Site 80
S739
Y
G
A
S
I
F
Q
S
K
E
S
S
S
V
L
Site 81
S742
S
I
F
Q
S
K
E
S
S
S
V
L
S
C
D
Site 82
S743
I
F
Q
S
K
E
S
S
S
V
L
S
C
D
I
Site 83
S744
F
Q
S
K
E
S
S
S
V
L
S
C
D
I
S
Site 84
S747
K
E
S
S
S
V
L
S
C
D
I
S
V
D
D
Site 85
Y756
D
I
S
V
D
D
K
Y
I
V
T
G
S
G
D
Site 86
S761
D
K
Y
I
V
T
G
S
G
D
K
K
A
T
V
Site 87
T767
G
S
G
D
K
K
A
T
V
Y
E
V
I
Y
_
Site 88
Y769
G
D
K
K
A
T
V
Y
E
V
I
Y
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation