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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TLE3
Full Name:
Transducin-like enhancer protein 3
Alias:
ESG; ESG3; GRG3; Grg-3; HsT18976; KIAA1547; Transducin-like enhancer of split 3
Type:
Transcription, coactivator/corepressor
Mass (Da):
83417
Number AA:
772
UniProt ID:
Q04726
International Prot ID:
IPI00219368
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
GO:0009887
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
G
Q
P
G
F
K
F
T
V
A
E
S
C
D
R
Site 2
S25
F
K
F
T
V
A
E
S
C
D
R
I
K
D
E
Site 3
T55
D
K
L
A
N
E
K
T
E
M
Q
R
H
Y
V
Site 4
Y61
K
T
E
M
Q
R
H
Y
V
M
Y
Y
E
M
S
Site 5
Y64
M
Q
R
H
Y
V
M
Y
Y
E
M
S
Y
G
L
Site 6
Y65
Q
R
H
Y
V
M
Y
Y
E
M
S
Y
G
L
N
Site 7
S97
A
Q
I
M
P
F
L
S
Q
E
H
Q
Q
Q
V
Site 8
T115
V
E
R
A
K
Q
V
T
M
T
E
L
N
A
I
Site 9
S134
Q
L
Q
A
Q
H
L
S
H
A
T
H
G
P
P
Site 10
S149
V
Q
L
P
P
H
P
S
G
L
Q
P
P
G
I
Site 11
T179
L
G
S
Q
A
H
L
T
V
K
D
E
K
N
H
Site 12
S196
L
D
H
R
E
R
E
S
S
A
N
N
S
V
S
Site 13
S197
D
H
R
E
R
E
S
S
A
N
N
S
V
S
P
Site 14
S201
R
E
S
S
A
N
N
S
V
S
P
S
E
S
L
Site 15
S203
S
S
A
N
N
S
V
S
P
S
E
S
L
R
A
Site 16
S205
A
N
N
S
V
S
P
S
E
S
L
R
A
S
E
Site 17
S207
N
S
V
S
P
S
E
S
L
R
A
S
E
K
H
Site 18
S211
P
S
E
S
L
R
A
S
E
K
H
R
G
S
A
Site 19
S217
A
S
E
K
H
R
G
S
A
D
Y
S
M
E
A
Site 20
Y220
K
H
R
G
S
A
D
Y
S
M
E
A
K
K
R
Site 21
S221
H
R
G
S
A
D
Y
S
M
E
A
K
K
R
K
Site 22
S234
R
K
A
E
E
K
D
S
L
S
R
Y
D
S
D
Site 23
S236
A
E
E
K
D
S
L
S
R
Y
D
S
D
G
D
Site 24
Y238
E
K
D
S
L
S
R
Y
D
S
D
G
D
K
S
Site 25
S240
D
S
L
S
R
Y
D
S
D
G
D
K
S
D
D
Site 26
S245
Y
D
S
D
G
D
K
S
D
D
L
V
V
D
V
Site 27
S253
D
D
L
V
V
D
V
S
N
E
D
P
A
T
P
Site 28
T259
V
S
N
E
D
P
A
T
P
R
V
S
P
A
H
Site 29
S263
D
P
A
T
P
R
V
S
P
A
H
S
P
P
E
Site 30
S267
P
R
V
S
P
A
H
S
P
P
E
N
G
L
D
Site 31
S278
N
G
L
D
K
A
R
S
L
K
K
D
A
P
T
Site 32
T285
S
L
K
K
D
A
P
T
S
P
A
S
V
A
S
Site 33
S286
L
K
K
D
A
P
T
S
P
A
S
V
A
S
S
Site 34
S289
D
A
P
T
S
P
A
S
V
A
S
S
S
S
T
Site 35
S292
T
S
P
A
S
V
A
S
S
S
S
T
P
S
S
Site 36
S293
S
P
A
S
V
A
S
S
S
S
T
P
S
S
K
Site 37
S294
P
A
S
V
A
S
S
S
S
T
P
S
S
K
T
Site 38
S295
A
S
V
A
S
S
S
S
T
P
S
S
K
T
K
Site 39
T296
S
V
A
S
S
S
S
T
P
S
S
K
T
K
D
Site 40
S298
A
S
S
S
S
T
P
S
S
K
T
K
D
L
G
Site 41
S299
S
S
S
S
T
P
S
S
K
T
K
D
L
G
H
Site 42
S310
D
L
G
H
N
D
K
S
S
T
P
G
L
K
S
Site 43
S311
L
G
H
N
D
K
S
S
T
P
G
L
K
S
N
Site 44
T312
G
H
N
D
K
S
S
T
P
G
L
K
S
N
T
Site 45
S317
S
S
T
P
G
L
K
S
N
T
P
T
P
R
N
Site 46
T319
T
P
G
L
K
S
N
T
P
T
P
R
N
D
A
Site 47
T321
G
L
K
S
N
T
P
T
P
R
N
D
A
P
T
Site 48
T328
T
P
R
N
D
A
P
T
P
G
T
S
T
T
P
Site 49
T331
N
D
A
P
T
P
G
T
S
T
T
P
G
L
R
Site 50
S332
D
A
P
T
P
G
T
S
T
T
P
G
L
R
S
Site 51
T333
A
P
T
P
G
T
S
T
T
P
G
L
R
S
M
Site 52
T334
P
T
P
G
T
S
T
T
P
G
L
R
S
M
P
Site 53
S339
S
T
T
P
G
L
R
S
M
P
G
K
P
P
G
Site 54
S382
S
H
H
E
M
N
G
S
L
T
S
P
G
A
Y
Site 55
S385
E
M
N
G
S
L
T
S
P
G
A
Y
A
G
L
Site 56
S413
A
A
A
A
Y
G
R
S
P
M
V
S
F
G
A
Site 57
T432
P
H
P
P
M
R
A
T
G
L
P
S
S
L
A
Site 58
Y448
I
P
G
G
K
P
A
Y
S
F
H
V
S
A
D
Site 59
S449
P
G
G
K
P
A
Y
S
F
H
V
S
A
D
G
Site 60
S453
P
A
Y
S
F
H
V
S
A
D
G
Q
M
Q
P
Site 61
T482
R
H
A
R
Q
I
N
T
L
S
H
G
E
V
V
Site 62
Y502
S
N
P
T
R
H
V
Y
T
G
G
K
G
C
V
Site 63
S515
C
V
K
I
W
D
I
S
Q
P
G
S
K
S
P
Site 64
S519
W
D
I
S
Q
P
G
S
K
S
P
I
S
Q
L
Site 65
S521
I
S
Q
P
G
S
K
S
P
I
S
Q
L
D
C
Site 66
S524
P
G
S
K
S
P
I
S
Q
L
D
C
L
N
R
Site 67
Y534
D
C
L
N
R
D
N
Y
I
R
S
C
K
L
L
Site 68
T565
I
W
D
L
A
S
P
T
P
R
I
K
A
E
L
Site 69
T573
P
R
I
K
A
E
L
T
S
S
A
P
A
C
Y
Site 70
S622
Q
G
H
T
D
G
A
S
C
I
D
I
S
H
D
Site 71
T631
I
D
I
S
H
D
G
T
K
L
W
T
G
G
L
Site 72
T641
W
T
G
G
L
D
N
T
V
R
S
W
D
L
R
Site 73
T659
Q
L
Q
Q
H
D
F
T
S
Q
I
F
S
L
G
Site 74
S660
L
Q
Q
H
D
F
T
S
Q
I
F
S
L
G
Y
Site 75
Y694
H
H
T
K
P
D
K
Y
Q
L
H
L
H
E
S
Site 76
S701
Y
Q
L
H
L
H
E
S
C
V
L
S
L
K
F
Site 77
S705
L
H
E
S
C
V
L
S
L
K
F
A
Y
C
G
Site 78
T729
N
L
L
N
A
W
R
T
P
Y
G
A
S
I
F
Site 79
Y731
L
N
A
W
R
T
P
Y
G
A
S
I
F
Q
S
Site 80
S734
W
R
T
P
Y
G
A
S
I
F
Q
S
K
E
S
Site 81
S738
Y
G
A
S
I
F
Q
S
K
E
S
S
S
V
L
Site 82
S741
S
I
F
Q
S
K
E
S
S
S
V
L
S
C
D
Site 83
S742
I
F
Q
S
K
E
S
S
S
V
L
S
C
D
I
Site 84
S743
F
Q
S
K
E
S
S
S
V
L
S
C
D
I
S
Site 85
S746
K
E
S
S
S
V
L
S
C
D
I
S
A
D
D
Site 86
Y755
D
I
S
A
D
D
K
Y
I
V
T
G
S
G
D
Site 87
S760
D
K
Y
I
V
T
G
S
G
D
K
K
A
T
V
Site 88
T766
G
S
G
D
K
K
A
T
V
Y
E
V
I
Y
_
Site 89
Y768
G
D
K
K
A
T
V
Y
E
V
I
Y
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation