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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NOTCH2
Full Name:
Neurogenic locus notch homolog protein 2
Alias:
Motch B; NOTC2; Notch 2 extracellular truncation; Notch2; NTC2
Type:
Receptor, misc.
Mass (Da):
265405
Number AA:
2471
UniProt ID:
Q04721
International Prot ID:
IPI00297655
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009986
GO:0005887
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0003706
GO:0046982
PhosphoSite+
KinaseNET
Biological Process:
GO:0007219
GO:0006916
GO:0007050
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T436
H
A
G
K
C
V
N
T
D
G
A
F
H
C
E
Site 2
S1708
K
R
K
R
K
H
G
S
L
W
L
P
E
G
F
Site 3
T1716
L
W
L
P
E
G
F
T
L
R
R
D
A
S
N
Site 4
S1722
F
T
L
R
R
D
A
S
N
H
K
R
R
E
P
Site 5
S1745
K
N
L
S
V
Q
V
S
E
A
N
L
I
G
T
Site 6
S1778
A
E
D
E
A
L
L
S
E
E
D
D
P
I
D
Site 7
T1790
P
I
D
R
R
P
W
T
Q
Q
H
L
E
A
A
Site 8
T1802
E
A
A
D
I
R
R
T
P
S
L
A
L
T
P
Site 9
S1804
A
D
I
R
R
T
P
S
L
A
L
T
P
P
Q
Site 10
T1808
R
T
P
S
L
A
L
T
P
P
Q
A
E
Q
E
Site 11
S1841
L
A
S
L
R
G
G
S
S
D
L
S
D
E
D
Site 12
S1842
A
S
L
R
G
G
S
S
D
L
S
D
E
D
E
Site 13
S1845
R
G
G
S
S
D
L
S
D
E
D
E
D
A
E
Site 14
S1854
E
D
E
D
A
E
D
S
S
A
N
I
I
T
D
Site 15
S1855
D
E
D
A
E
D
S
S
A
N
I
I
T
D
L
Site 16
T1876
L
Q
A
Q
T
D
R
T
G
E
M
A
L
H
L
Site 17
S1888
L
H
L
A
A
R
Y
S
R
A
D
A
A
K
R
Site 18
T1935
I
L
I
R
N
R
V
T
D
L
D
A
R
M
N
Site 19
T1946
A
R
M
N
D
G
T
T
P
L
I
L
A
A
R
Site 20
T2012
M
Q
D
N
K
E
E
T
P
L
F
L
A
A
R
Site 21
Y2023
L
A
A
R
E
G
S
Y
E
A
A
K
I
L
L
Site 22
Y2065
I
V
R
L
L
D
E
Y
N
V
T
P
S
P
P
Site 23
T2068
L
L
D
E
Y
N
V
T
P
S
P
P
G
T
V
Site 24
S2070
D
E
Y
N
V
T
P
S
P
P
G
T
V
L
T
Site 25
T2074
V
T
P
S
P
P
G
T
V
L
T
S
A
L
S
Site 26
S2078
P
P
G
T
V
L
T
S
A
L
S
P
V
I
C
Site 27
S2081
T
V
L
T
S
A
L
S
P
V
I
C
G
P
N
Site 28
S2090
V
I
C
G
P
N
R
S
F
L
S
L
K
H
T
Site 29
S2093
G
P
N
R
S
F
L
S
L
K
H
T
P
M
G
Site 30
T2097
S
F
L
S
L
K
H
T
P
M
G
K
K
S
R
Site 31
S2103
H
T
P
M
G
K
K
S
R
R
P
S
A
K
S
Site 32
S2107
G
K
K
S
R
R
P
S
A
K
S
T
M
P
T
Site 33
S2110
S
R
R
P
S
A
K
S
T
M
P
T
S
L
P
Site 34
T2111
R
R
P
S
A
K
S
T
M
P
T
S
L
P
N
Site 35
T2114
S
A
K
S
T
M
P
T
S
L
P
N
L
A
K
Site 36
S2115
A
K
S
T
M
P
T
S
L
P
N
L
A
K
E
Site 37
S2129
E
A
K
D
A
K
G
S
R
R
K
K
S
L
S
Site 38
S2134
K
G
S
R
R
K
K
S
L
S
E
K
V
Q
L
Site 39
S2136
S
R
R
K
K
S
L
S
E
K
V
Q
L
S
E
Site 40
S2142
L
S
E
K
V
Q
L
S
E
S
S
V
T
L
S
Site 41
S2144
E
K
V
Q
L
S
E
S
S
V
T
L
S
P
V
Site 42
S2145
K
V
Q
L
S
E
S
S
V
T
L
S
P
V
D
Site 43
T2147
Q
L
S
E
S
S
V
T
L
S
P
V
D
S
L
Site 44
S2149
S
E
S
S
V
T
L
S
P
V
D
S
L
E
S
Site 45
S2153
V
T
L
S
P
V
D
S
L
E
S
P
H
T
Y
Site 46
S2156
S
P
V
D
S
L
E
S
P
H
T
Y
V
S
D
Site 47
T2159
D
S
L
E
S
P
H
T
Y
V
S
D
T
T
S
Site 48
Y2160
S
L
E
S
P
H
T
Y
V
S
D
T
T
S
S
Site 49
S2162
E
S
P
H
T
Y
V
S
D
T
T
S
S
P
M
Site 50
T2164
P
H
T
Y
V
S
D
T
T
S
S
P
M
I
T
Site 51
T2165
H
T
Y
V
S
D
T
T
S
S
P
M
I
T
S
Site 52
S2166
T
Y
V
S
D
T
T
S
S
P
M
I
T
S
P
Site 53
S2167
Y
V
S
D
T
T
S
S
P
M
I
T
S
P
G
Site 54
S2200
V
H
A
Q
H
A
L
S
F
S
N
L
H
E
M
Site 55
S2222
S
T
V
L
P
S
V
S
Q
L
L
S
H
H
H
Site 56
S2226
P
S
V
S
Q
L
L
S
H
H
H
I
V
S
P
Site 57
S2232
L
S
H
H
H
I
V
S
P
G
S
G
S
A
G
Site 58
S2235
H
H
I
V
S
P
G
S
G
S
A
G
S
L
S
Site 59
S2240
P
G
S
G
S
A
G
S
L
S
R
L
H
P
V
Site 60
S2242
S
G
S
A
G
S
L
S
R
L
H
P
V
P
V
Site 61
Y2264
M
E
V
N
E
T
Q
Y
N
E
M
F
G
M
V
Site 62
S2286
H
P
G
I
A
P
Q
S
R
P
P
E
G
K
H
Site 63
T2295
P
P
E
G
K
H
I
T
T
P
R
E
P
L
P
Site 64
T2296
P
E
G
K
H
I
T
T
P
R
E
P
L
P
P
Site 65
S2326
A
G
A
P
Q
P
Q
S
T
C
P
P
A
V
A
Site 66
T2327
G
A
P
Q
P
Q
S
T
C
P
P
A
V
A
G
Site 67
Y2340
A
G
P
L
P
T
M
Y
Q
I
P
E
M
A
R
Site 68
T2368
Q
D
G
Q
V
A
Q
T
I
L
P
A
Y
H
P
Site 69
Y2373
A
Q
T
I
L
P
A
Y
H
P
F
P
A
S
V
Site 70
S2379
A
Y
H
P
F
P
A
S
V
G
K
Y
P
T
P
Site 71
Y2383
F
P
A
S
V
G
K
Y
P
T
P
P
S
Q
H
Site 72
T2385
A
S
V
G
K
Y
P
T
P
P
S
Q
H
S
Y
Site 73
S2388
G
K
Y
P
T
P
P
S
Q
H
S
Y
A
S
S
Site 74
S2391
P
T
P
P
S
Q
H
S
Y
A
S
S
N
A
A
Site 75
Y2392
T
P
P
S
Q
H
S
Y
A
S
S
N
A
A
E
Site 76
S2395
S
Q
H
S
Y
A
S
S
N
A
A
E
R
T
P
Site 77
T2401
S
S
N
A
A
E
R
T
P
S
H
S
G
H
L
Site 78
S2403
N
A
A
E
R
T
P
S
H
S
G
H
L
Q
G
Site 79
S2405
A
E
R
T
P
S
H
S
G
H
L
Q
G
E
H
Site 80
Y2414
H
L
Q
G
E
H
P
Y
L
T
P
S
P
E
S
Site 81
T2416
Q
G
E
H
P
Y
L
T
P
S
P
E
S
P
D
Site 82
S2418
E
H
P
Y
L
T
P
S
P
E
S
P
D
Q
W
Site 83
S2421
Y
L
T
P
S
P
E
S
P
D
Q
W
S
S
S
Site 84
S2426
P
E
S
P
D
Q
W
S
S
S
S
P
H
S
A
Site 85
S2427
E
S
P
D
Q
W
S
S
S
S
P
H
S
A
S
Site 86
S2428
S
P
D
Q
W
S
S
S
S
P
H
S
A
S
D
Site 87
S2429
P
D
Q
W
S
S
S
S
P
H
S
A
S
D
W
Site 88
S2432
W
S
S
S
S
P
H
S
A
S
D
W
S
D
V
Site 89
S2434
S
S
S
P
H
S
A
S
D
W
S
D
V
T
T
Site 90
T2440
A
S
D
W
S
D
V
T
T
S
P
T
P
G
G
Site 91
T2441
S
D
W
S
D
V
T
T
S
P
T
P
G
G
A
Site 92
S2442
D
W
S
D
V
T
T
S
P
T
P
G
G
A
G
Site 93
T2444
S
D
V
T
T
S
P
T
P
G
G
A
G
G
G
Site 94
T2457
G
G
Q
R
G
P
G
T
H
M
S
E
P
P
H
Site 95
S2460
R
G
P
G
T
H
M
S
E
P
P
H
N
N
M
Site 96
Y2470
P
H
N
N
M
Q
V
Y
A
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation