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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATP7A
Full Name:
Copper-transporting ATPase 1
Alias:
ATPase, Cu++ transporting, alpha polypeptide; copper pump 1; MC1; Menkes disease-associated protein; MK; MNK; OHS
Type:
Transporter, Apoptosis, Vesicle protein, Chaperone, Hydrolase
Mass (Da):
163374
Number AA:
1500
UniProt ID:
Q04656
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016323
GO:0043025
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0032767
GO:0004008
PhosphoSite+
KinaseNET
Biological Process:
GO:0006754
GO:0042093
GO:0001974
Phosida
TranscriptoNet
STRING
Kinexus Products
Copper-transporting ATPase 1 pan-specific antibody AB-NN215-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN215-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S42
G
V
H
H
I
K
V
S
L
E
E
K
N
A
T
Site 2
T49
S
L
E
E
K
N
A
T
I
I
Y
D
P
K
L
Site 3
T58
I
Y
D
P
K
L
Q
T
P
K
T
L
Q
E
A
Site 4
T61
P
K
L
Q
T
P
K
T
L
Q
E
A
I
D
D
Site 5
T106
P
W
D
H
I
Q
S
T
L
L
K
T
K
G
V
Site 6
Y119
G
V
T
D
I
K
I
Y
P
Q
K
R
T
V
A
Site 7
S147
K
E
L
V
P
E
L
S
L
D
T
G
T
L
E
Site 8
T152
E
L
S
L
D
T
G
T
L
E
K
K
S
G
A
Site 9
S157
T
G
T
L
E
K
K
S
G
A
C
E
D
H
S
Site 10
S164
S
G
A
C
E
D
H
S
M
A
Q
A
G
E
V
Site 11
T188
T
C
H
S
C
T
S
T
I
E
G
K
I
G
K
Site 12
T212
S
L
D
N
Q
E
A
T
I
V
Y
Q
P
H
L
Site 13
S221
V
Y
Q
P
H
L
I
S
V
E
E
M
K
K
Q
Site 14
Y244
F
V
K
K
Q
P
K
Y
L
K
L
G
A
I
D
Site 15
T258
D
V
E
R
L
K
N
T
P
V
K
S
S
E
G
Site 16
S262
L
K
N
T
P
V
K
S
S
E
G
S
Q
Q
R
Site 17
S266
P
V
K
S
S
E
G
S
Q
Q
R
S
P
S
Y
Site 18
S270
S
E
G
S
Q
Q
R
S
P
S
Y
T
N
D
S
Site 19
S272
G
S
Q
Q
R
S
P
S
Y
T
N
D
S
T
A
Site 20
Y273
S
Q
Q
R
S
P
S
Y
T
N
D
S
T
A
T
Site 21
T274
Q
Q
R
S
P
S
Y
T
N
D
S
T
A
T
F
Site 22
S277
S
P
S
Y
T
N
D
S
T
A
T
F
I
I
D
Site 23
T278
P
S
Y
T
N
D
S
T
A
T
F
I
I
D
G
Site 24
S293
M
H
C
K
S
C
V
S
N
I
E
S
T
L
S
Site 25
S300
S
N
I
E
S
T
L
S
A
L
Q
Y
V
S
S
Site 26
Y321
N
R
S
A
I
V
K
Y
N
A
S
S
V
T
P
Site 27
S325
I
V
K
Y
N
A
S
S
V
T
P
E
S
L
R
Site 28
T327
K
Y
N
A
S
S
V
T
P
E
S
L
R
K
A
Site 29
S330
A
S
S
V
T
P
E
S
L
R
K
A
I
E
A
Site 30
S339
R
K
A
I
E
A
V
S
P
G
L
Y
R
V
S
Site 31
Y343
E
A
V
S
P
G
L
Y
R
V
S
I
T
S
E
Site 32
S346
S
P
G
L
Y
R
V
S
I
T
S
E
V
E
S
Site 33
S349
L
Y
R
V
S
I
T
S
E
V
E
S
T
S
N
Site 34
S353
S
I
T
S
E
V
E
S
T
S
N
S
P
S
S
Site 35
T354
I
T
S
E
V
E
S
T
S
N
S
P
S
S
S
Site 36
S355
T
S
E
V
E
S
T
S
N
S
P
S
S
S
S
Site 37
S357
E
V
E
S
T
S
N
S
P
S
S
S
S
L
Q
Site 38
S359
E
S
T
S
N
S
P
S
S
S
S
L
Q
K
I
Site 39
S360
S
T
S
N
S
P
S
S
S
S
L
Q
K
I
P
Site 40
S361
T
S
N
S
P
S
S
S
S
L
Q
K
I
P
L
Site 41
S362
S
N
S
P
S
S
S
S
L
Q
K
I
P
L
N
Site 42
S372
K
I
P
L
N
V
V
S
Q
P
L
T
Q
E
T
Site 43
S400
Q
S
I
E
G
V
I
S
K
K
P
G
V
K
S
Site 44
S407
S
K
K
P
G
V
K
S
I
R
V
S
L
A
N
Site 45
S411
G
V
K
S
I
R
V
S
L
A
N
S
N
G
T
Site 46
S415
I
R
V
S
L
A
N
S
N
G
T
V
E
Y
D
Site 47
S427
E
Y
D
P
L
L
T
S
P
E
T
L
R
G
A
Site 48
T430
P
L
L
T
S
P
E
T
L
R
G
A
I
E
D
Site 49
T443
E
D
M
G
F
D
A
T
L
S
D
T
N
E
P
Site 50
S445
M
G
F
D
A
T
L
S
D
T
N
E
P
L
V
Site 51
T476
E
F
Y
T
K
G
M
T
P
V
Q
D
K
E
E
Site 52
S488
K
E
E
G
K
N
S
S
K
C
Y
I
Q
V
T
Site 53
Y491
G
K
N
S
S
K
C
Y
I
Q
V
T
G
M
T
Site 54
Y517
L
R
R
E
E
G
I
Y
S
I
L
V
A
L
M
Site 55
S518
R
R
E
E
G
I
Y
S
I
L
V
A
L
M
A
Site 56
Y532
A
G
K
A
E
V
R
Y
N
P
A
V
I
Q
P
Site 57
S585
C
V
H
K
I
E
S
S
L
T
K
H
R
G
I
Site 58
T587
H
K
I
E
S
S
L
T
K
H
R
G
I
L
Y
Site 59
Y594
T
K
H
R
G
I
L
Y
C
S
V
A
L
A
T
Site 60
T601
Y
C
S
V
A
L
A
T
N
K
A
H
I
K
Y
Site 61
Y608
T
N
K
A
H
I
K
Y
D
P
E
I
I
G
P
Site 62
T621
G
P
R
D
I
I
H
T
I
E
S
L
G
F
E
Site 63
S630
E
S
L
G
F
E
A
S
L
V
K
K
D
R
S
Site 64
S637
S
L
V
K
K
D
R
S
A
S
H
L
D
H
K
Site 65
S639
V
K
K
D
R
S
A
S
H
L
D
H
K
R
E
Site 66
S653
E
I
R
Q
W
R
R
S
F
L
V
S
L
F
F
Site 67
Y736
W
Y
F
Y
I
Q
A
Y
K
A
L
K
H
K
T
Site 68
T779
R
A
K
V
N
P
I
T
F
F
D
T
P
P
M
Site 69
S833
D
S
D
N
I
L
L
S
E
E
Q
V
D
V
E
Site 70
S872
G
H
S
M
V
D
E
S
L
I
T
G
E
A
M
Site 71
S926
L
V
E
E
A
Q
T
S
K
A
P
I
Q
Q
F
Site 72
T969
L
N
F
E
I
V
E
T
Y
F
P
G
Y
N
R
Site 73
Y970
N
F
E
I
V
E
T
Y
F
P
G
Y
N
R
S
Site 74
Y974
V
E
T
Y
F
P
G
Y
N
R
S
I
S
R
T
Site 75
S977
Y
F
P
G
Y
N
R
S
I
S
R
T
E
T
I
Site 76
S979
P
G
Y
N
R
S
I
S
R
T
E
T
I
I
R
Site 77
T981
Y
N
R
S
I
S
R
T
E
T
I
I
R
F
A
Site 78
T983
R
S
I
S
R
T
E
T
I
I
R
F
A
F
Q
Site 79
T1053
T
G
T
I
T
H
G
T
P
V
V
N
Q
V
K
Site 80
T1063
V
N
Q
V
K
V
L
T
E
S
N
R
I
S
H
Site 81
S1065
Q
V
K
V
L
T
E
S
N
R
I
S
H
H
K
Site 82
S1069
L
T
E
S
N
R
I
S
H
H
K
I
L
A
I
Site 83
T1079
K
I
L
A
I
V
G
T
A
E
S
N
S
E
H
Site 84
S1082
A
I
V
G
T
A
E
S
N
S
E
H
P
L
G
Site 85
S1084
V
G
T
A
E
S
N
S
E
H
P
L
G
T
A
Site 86
Y1095
L
G
T
A
I
T
K
Y
C
K
Q
E
L
D
T
Site 87
T1102
Y
C
K
Q
E
L
D
T
E
T
L
G
T
C
I
Site 88
S1153
S
L
V
Q
I
D
A
S
N
E
Q
S
S
T
S
Site 89
S1157
I
D
A
S
N
E
Q
S
S
T
S
S
S
M
I
Site 90
S1158
D
A
S
N
E
Q
S
S
T
S
S
S
M
I
I
Site 91
T1159
A
S
N
E
Q
S
S
T
S
S
S
M
I
I
D
Site 92
S1160
S
N
E
Q
S
S
T
S
S
S
M
I
I
D
A
Site 93
S1161
N
E
Q
S
S
T
S
S
S
M
I
I
D
A
Q
Site 94
S1162
E
Q
S
S
T
S
S
S
M
I
I
D
A
Q
I
Site 95
Y1178
N
A
L
N
A
Q
Q
Y
K
V
L
I
G
N
R
Site 96
T1204
N
D
V
N
D
F
M
T
E
H
E
R
K
G
R
Site 97
S1258
V
L
M
T
G
D
N
S
K
T
A
R
S
I
A
Site 98
T1260
M
T
G
D
N
S
K
T
A
R
S
I
A
S
Q
Site 99
S1263
D
N
S
K
T
A
R
S
I
A
S
Q
V
G
I
Site 100
S1266
K
T
A
R
S
I
A
S
Q
V
G
I
T
K
V
Site 101
T1351
S
I
D
L
S
R
E
T
V
K
R
I
R
I
N
Site 102
S1399
A
M
A
A
S
S
V
S
V
V
L
S
S
L
F
Site 103
Y1410
S
S
L
F
L
K
L
Y
R
K
P
T
Y
E
S
Site 104
T1414
L
K
L
Y
R
K
P
T
Y
E
S
Y
E
L
P
Site 105
Y1415
K
L
Y
R
K
P
T
Y
E
S
Y
E
L
P
A
Site 106
Y1418
R
K
P
T
Y
E
S
Y
E
L
P
A
R
S
Q
Site 107
S1424
S
Y
E
L
P
A
R
S
Q
I
G
Q
K
S
P
Site 108
S1430
R
S
Q
I
G
Q
K
S
P
S
E
I
S
V
H
Site 109
S1432
Q
I
G
Q
K
S
P
S
E
I
S
V
H
V
G
Site 110
S1435
Q
K
S
P
S
E
I
S
V
H
V
G
I
D
D
Site 111
T1443
V
H
V
G
I
D
D
T
S
R
N
S
P
K
L
Site 112
S1444
H
V
G
I
D
D
T
S
R
N
S
P
K
L
G
Site 113
S1447
I
D
D
T
S
R
N
S
P
K
L
G
L
L
D
Site 114
Y1459
L
L
D
R
I
V
N
Y
S
R
A
S
I
N
S
Site 115
S1460
L
D
R
I
V
N
Y
S
R
A
S
I
N
S
L
Site 116
S1463
I
V
N
Y
S
R
A
S
I
N
S
L
L
S
D
Site 117
S1466
Y
S
R
A
S
I
N
S
L
L
S
D
K
R
S
Site 118
S1469
A
S
I
N
S
L
L
S
D
K
R
S
L
N
S
Site 119
S1473
S
L
L
S
D
K
R
S
L
N
S
V
V
T
S
Site 120
S1476
S
D
K
R
S
L
N
S
V
V
T
S
E
P
D
Site 121
T1479
R
S
L
N
S
V
V
T
S
E
P
D
K
H
S
Site 122
S1480
S
L
N
S
V
V
T
S
E
P
D
K
H
S
L
Site 123
S1486
T
S
E
P
D
K
H
S
L
L
V
G
D
F
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation