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Updated November 2019
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Protein Info
Short Name:
MLL
Full Name:
Histone-lysine N-methyltransferase MLL
Alias:
ALL1; ALL-1; CXXC7; HRX; HTRX; HTRX1; KMT2A; MLL1A; Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); Myeloid/lymphoid or mixed-lineage leukemia (trithorax); Trithorax-like protein; TRX1; Zinc finger protein HRX
Type:
EC 2.1.1.43; Cell cycle regulation; Methyltransferase; Transcription factor
Mass (Da):
431764
Number AA:
3969
UniProt ID:
Q03164
International Prot ID:
IPI00009286
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0035097
Uniprot
OncoNet
Molecular Function:
GO:0003680
GO:0003702
GO:0042800
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0016568
GO:0035162
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T15
R
F
P
A
R
P
G
T
T
G
G
G
G
G
G
Site 2
T16
F
P
A
R
P
G
T
T
G
G
G
G
G
G
G
Site 3
S85
A
A
A
A
S
A
A
S
S
S
S
A
S
S
S
Site 4
S86
A
A
A
S
A
A
S
S
S
S
A
S
S
S
S
Site 5
S87
A
A
S
A
A
S
S
S
S
A
S
S
S
S
S
Site 6
S88
A
S
A
A
S
S
S
S
A
S
S
S
S
S
S
Site 7
S90
A
A
S
S
S
S
A
S
S
S
S
S
S
S
S
Site 8
S91
A
S
S
S
S
A
S
S
S
S
S
S
S
S
S
Site 9
S92
S
S
S
S
A
S
S
S
S
S
S
S
S
S
A
Site 10
S93
S
S
S
A
S
S
S
S
S
S
S
S
S
A
S
Site 11
S94
S
S
A
S
S
S
S
S
S
S
S
S
A
S
S
Site 12
S95
S
A
S
S
S
S
S
S
S
S
S
A
S
S
G
Site 13
S96
A
S
S
S
S
S
S
S
S
S
A
S
S
G
P
Site 14
S97
S
S
S
S
S
S
S
S
S
A
S
S
G
P
A
Site 15
S98
S
S
S
S
S
S
S
S
A
S
S
G
P
A
L
Site 16
S100
S
S
S
S
S
S
A
S
S
G
P
A
L
L
R
Site 17
S101
S
S
S
S
S
A
S
S
G
P
A
L
L
R
V
Site 18
S136
F
R
A
V
F
G
E
S
G
G
G
G
G
S
G
Site 19
S142
E
S
G
G
G
G
G
S
G
E
D
E
Q
F
L
Site 20
S153
E
Q
F
L
G
F
G
S
D
E
E
V
R
V
R
Site 21
S161
D
E
E
V
R
V
R
S
P
T
R
S
P
S
V
Site 22
T163
E
V
R
V
R
S
P
T
R
S
P
S
V
K
T
Site 23
S165
R
V
R
S
P
T
R
S
P
S
V
K
T
S
P
Site 24
S167
R
S
P
T
R
S
P
S
V
K
T
S
P
R
K
Site 25
T170
T
R
S
P
S
V
K
T
S
P
R
K
P
R
G
Site 26
S171
R
S
P
S
V
K
T
S
P
R
K
P
R
G
R
Site 27
S181
K
P
R
G
R
P
R
S
G
S
D
R
N
S
A
Site 28
S183
R
G
R
P
R
S
G
S
D
R
N
S
A
I
L
Site 29
S187
R
S
G
S
D
R
N
S
A
I
L
S
D
P
S
Site 30
S191
D
R
N
S
A
I
L
S
D
P
S
V
F
S
P
Site 31
S194
S
A
I
L
S
D
P
S
V
F
S
P
L
N
K
Site 32
S197
L
S
D
P
S
V
F
S
P
L
N
K
S
E
T
Site 33
S202
V
F
S
P
L
N
K
S
E
T
K
S
G
D
K
Site 34
T204
S
P
L
N
K
S
E
T
K
S
G
D
K
I
K
Site 35
S206
L
N
K
S
E
T
K
S
G
D
K
I
K
K
K
Site 36
S215
D
K
I
K
K
K
D
S
K
S
I
E
K
K
R
Site 37
S217
I
K
K
K
D
S
K
S
I
E
K
K
R
G
R
Site 38
T227
K
K
R
G
R
P
P
T
F
P
G
V
K
I
K
Site 39
S242
I
T
H
G
K
D
I
S
E
L
P
K
G
N
K
Site 40
S252
P
K
G
N
K
E
D
S
L
K
K
I
K
R
T
Site 41
T259
S
L
K
K
I
K
R
T
P
S
A
T
F
Q
Q
Site 42
S261
K
K
I
K
R
T
P
S
A
T
F
Q
Q
A
T
Site 43
T263
I
K
R
T
P
S
A
T
F
Q
Q
A
T
K
I
Site 44
T268
S
A
T
F
Q
Q
A
T
K
I
K
K
L
R
A
Site 45
S279
K
L
R
A
G
K
L
S
P
L
K
S
K
F
K
Site 46
S283
G
K
L
S
P
L
K
S
K
F
K
T
G
K
L
Site 47
T287
P
L
K
S
K
F
K
T
G
K
L
Q
I
G
R
Site 48
S308
R
R
R
G
R
P
P
S
T
E
R
I
K
T
P
Site 49
T309
R
R
G
R
P
P
S
T
E
R
I
K
T
P
S
Site 50
T314
P
S
T
E
R
I
K
T
P
S
G
L
L
I
N
Site 51
S316
T
E
R
I
K
T
P
S
G
L
L
I
N
S
E
Site 52
S322
P
S
G
L
L
I
N
S
E
L
E
K
P
Q
K
Site 53
T337
V
R
K
D
K
E
G
T
P
P
L
T
K
E
D
Site 54
T341
K
E
G
T
P
P
L
T
K
E
D
K
T
V
V
Site 55
T346
P
L
T
K
E
D
K
T
V
V
R
Q
S
P
R
Site 56
S351
D
K
T
V
V
R
Q
S
P
R
R
I
K
P
V
Site 57
S363
K
P
V
R
I
I
P
S
S
K
R
T
D
A
T
Site 58
S364
P
V
R
I
I
P
S
S
K
R
T
D
A
T
I
Site 59
T370
S
S
K
R
T
D
A
T
I
A
K
Q
L
L
Q
Site 60
T401
L
Q
G
R
K
V
K
T
Q
V
K
N
I
R
Q
Site 61
S419
P
V
V
S
A
I
S
S
R
I
I
K
T
P
R
Site 62
T424
I
S
S
R
I
I
K
T
P
R
R
F
I
E
D
Site 63
Y434
R
F
I
E
D
E
D
Y
D
P
P
I
K
I
A
Site 64
S445
I
K
I
A
R
L
E
S
T
P
N
S
R
F
S
Site 65
T446
K
I
A
R
L
E
S
T
P
N
S
R
F
S
A
Site 66
S449
R
L
E
S
T
P
N
S
R
F
S
A
P
S
C
Site 67
S452
S
T
P
N
S
R
F
S
A
P
S
C
G
S
S
Site 68
S455
N
S
R
F
S
A
P
S
C
G
S
S
E
K
S
Site 69
S458
F
S
A
P
S
C
G
S
S
E
K
S
S
A
A
Site 70
S459
S
A
P
S
C
G
S
S
E
K
S
S
A
A
S
Site 71
S462
S
C
G
S
S
E
K
S
S
A
A
S
Q
H
S
Site 72
S463
C
G
S
S
E
K
S
S
A
A
S
Q
H
S
S
Site 73
S466
S
E
K
S
S
A
A
S
Q
H
S
S
Q
M
S
Site 74
S469
S
S
A
A
S
Q
H
S
S
Q
M
S
S
D
S
Site 75
S470
S
A
A
S
Q
H
S
S
Q
M
S
S
D
S
S
Site 76
S473
S
Q
H
S
S
Q
M
S
S
D
S
S
R
S
S
Site 77
S474
Q
H
S
S
Q
M
S
S
D
S
S
R
S
S
S
Site 78
S476
S
S
Q
M
S
S
D
S
S
R
S
S
S
P
S
Site 79
S477
S
Q
M
S
S
D
S
S
R
S
S
S
P
S
V
Site 80
S479
M
S
S
D
S
S
R
S
S
S
P
S
V
D
T
Site 81
S480
S
S
D
S
S
R
S
S
S
P
S
V
D
T
S
Site 82
S481
S
D
S
S
R
S
S
S
P
S
V
D
T
S
T
Site 83
S483
S
S
R
S
S
S
P
S
V
D
T
S
T
D
S
Site 84
T486
S
S
S
P
S
V
D
T
S
T
D
S
Q
A
S
Site 85
S487
S
S
P
S
V
D
T
S
T
D
S
Q
A
S
E
Site 86
T488
S
P
S
V
D
T
S
T
D
S
Q
A
S
E
E
Site 87
S490
S
V
D
T
S
T
D
S
Q
A
S
E
E
I
Q
Site 88
S504
Q
V
L
P
E
E
R
S
D
T
P
E
V
H
P
Site 89
T506
L
P
E
E
R
S
D
T
P
E
V
H
P
P
L
Site 90
S516
V
H
P
P
L
P
I
S
Q
S
P
E
N
E
S
Site 91
S518
P
P
L
P
I
S
Q
S
P
E
N
E
S
N
D
Site 92
S523
S
Q
S
P
E
N
E
S
N
D
R
R
S
R
R
Site 93
S528
N
E
S
N
D
R
R
S
R
R
Y
S
V
S
E
Site 94
Y531
N
D
R
R
S
R
R
Y
S
V
S
E
R
S
F
Site 95
S532
D
R
R
S
R
R
Y
S
V
S
E
R
S
F
G
Site 96
S534
R
S
R
R
Y
S
V
S
E
R
S
F
G
S
R
Site 97
S537
R
Y
S
V
S
E
R
S
F
G
S
R
T
T
K
Site 98
T543
R
S
F
G
S
R
T
T
K
K
L
S
T
L
Q
Site 99
S547
S
R
T
T
K
K
L
S
T
L
Q
S
A
P
Q
Site 100
T548
R
T
T
K
K
L
S
T
L
Q
S
A
P
Q
Q
Site 101
S551
K
K
L
S
T
L
Q
S
A
P
Q
Q
Q
T
S
Site 102
S558
S
A
P
Q
Q
Q
T
S
S
S
P
P
P
P
L
Site 103
S559
A
P
Q
Q
Q
T
S
S
S
P
P
P
P
L
L
Site 104
S560
P
Q
Q
Q
T
S
S
S
P
P
P
P
L
L
T
Site 105
T567
S
P
P
P
P
L
L
T
P
P
P
P
L
Q
P
Site 106
S576
P
P
P
L
Q
P
A
S
S
I
S
D
H
T
P
Site 107
S577
P
P
L
Q
P
A
S
S
I
S
D
H
T
P
W
Site 108
T582
A
S
S
I
S
D
H
T
P
W
L
M
P
P
T
Site 109
S600
A
S
P
F
L
P
A
S
T
A
P
M
Q
G
K
Site 110
S610
P
M
Q
G
K
R
K
S
I
L
R
E
P
T
F
Site 111
T616
K
S
I
L
R
E
P
T
F
R
W
T
S
L
K
Site 112
T620
R
E
P
T
F
R
W
T
S
L
K
H
S
R
S
Site 113
S621
E
P
T
F
R
W
T
S
L
K
H
S
R
S
E
Site 114
S625
R
W
T
S
L
K
H
S
R
S
E
P
Q
Y
F
Site 115
S627
T
S
L
K
H
S
R
S
E
P
Q
Y
F
S
S
Site 116
Y631
H
S
R
S
E
P
Q
Y
F
S
S
A
K
Y
A
Site 117
Y637
Q
Y
F
S
S
A
K
Y
A
K
E
G
L
I
R
Site 118
T657
N
F
R
P
P
P
L
T
P
E
D
V
G
F
A
Site 119
S665
P
E
D
V
G
F
A
S
G
F
S
A
S
G
T
Site 120
S680
A
A
S
A
R
L
F
S
P
L
H
S
G
T
R
Site 121
S684
R
L
F
S
P
L
H
S
G
T
R
F
D
M
H
Site 122
S694
R
F
D
M
H
K
R
S
P
L
L
R
A
P
R
Site 123
T703
L
L
R
A
P
R
F
T
P
S
E
A
H
S
R
Site 124
S705
R
A
P
R
F
T
P
S
E
A
H
S
R
I
F
Site 125
S709
F
T
P
S
E
A
H
S
R
I
F
E
S
V
T
Site 126
S714
A
H
S
R
I
F
E
S
V
T
L
P
S
N
R
Site 127
T716
S
R
I
F
E
S
V
T
L
P
S
N
R
T
S
Site 128
S719
F
E
S
V
T
L
P
S
N
R
T
S
A
G
T
Site 129
T722
V
T
L
P
S
N
R
T
S
A
G
T
S
S
S
Site 130
S723
T
L
P
S
N
R
T
S
A
G
T
S
S
S
G
Site 131
T726
S
N
R
T
S
A
G
T
S
S
S
G
V
S
N
Site 132
S727
N
R
T
S
A
G
T
S
S
S
G
V
S
N
R
Site 133
S728
R
T
S
A
G
T
S
S
S
G
V
S
N
R
K
Site 134
S729
T
S
A
G
T
S
S
S
G
V
S
N
R
K
R
Site 135
S732
G
T
S
S
S
G
V
S
N
R
K
R
K
R
K
Site 136
S742
K
R
K
R
K
V
F
S
P
I
R
S
E
P
R
Site 137
S746
K
V
F
S
P
I
R
S
E
P
R
S
P
S
H
Site 138
S750
P
I
R
S
E
P
R
S
P
S
H
S
M
R
T
Site 139
S752
R
S
E
P
R
S
P
S
H
S
M
R
T
R
S
Site 140
S754
E
P
R
S
P
S
H
S
M
R
T
R
S
G
R
Site 141
T757
S
P
S
H
S
M
R
T
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S2796
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S2802
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S2806
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S2807
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Site 451
T2812
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Site 452
S2813
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Site 453
T2814
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Site 454
T2823
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Site 455
Y2824
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Site 456
S2831
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Site 457
S2833
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Site 458
S2838
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Site 459
S2859
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Site 460
S2866
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Site 461
S2869
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Site 462
S2870
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Site 463
S2871
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S2872
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Site 465
S2885
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S2898
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Site 467
T2903
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Site 468
T2904
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Site 469
S2909
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Site 470
S2910
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S2912
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S2913
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Site 473
S2914
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Site 474
S2916
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S2932
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Site 476
T2935
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Site 477
T2936
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Site 478
S2938
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Site 479
T2940
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Site 480
S2943
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S2947
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S2953
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Site 483
S2955
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T2961
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Site 485
S2966
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S2970
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Site 487
S2972
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Site 488
S2978
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Site 489
T2984
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Site 490
T2990
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Site 491
S3005
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Site 492
S3006
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Site 493
S3011
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Site 494
T3023
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G
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Site 495
S3026
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Site 496
S3027
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Site 497
T3028
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Site 498
S3036
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Site 499
T3038
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Site 500
Y3046
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Site 501
S3050
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Site 502
T3051
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Site 503
S3053
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Site 504
S3057
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Site 505
S3060
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Site 506
T3067
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Site 507
Y3089
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Site 508
T3093
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Site 509
T3105
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Site 510
S3106
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Site 511
S3107
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Site 512
S3110
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Site 513
T3111
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Site 514
S3113
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Site 515
T3117
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Site 516
T3119
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Site 517
S3138
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Site 518
S3142
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Site 519
S3144
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Site 520
S3148
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S3150
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Site 522
S3157
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Site 523
S3164
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Site 524
T3169
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Site 525
S3171
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Site 526
S3172
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Site 527
S3178
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Site 528
S3199
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Site 529
S3201
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Site 530
S3202
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Site 531
T3205
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Site 532
S3208
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Site 533
T3209
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Site 534
T3210
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Site 535
T3213
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S3216
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Site 537
S3224
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Site 538
T3228
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Site 539
S3237
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Site 540
S3238
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T3239
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Site 542
S3241
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Site 543
S3246
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Site 544
T3258
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Site 545
S3260
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S3267
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S3273
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S3277
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S3278
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T3281
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S3289
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Site 552
S3291
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Site 553
Y3295
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S3320
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S3324
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T3327
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S3328
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S3332
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T3349
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Site 561
T3350
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T3351
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S3355
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Site 565
S3357
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T3372
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S3386
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Site 568
S3412
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Site 569
T3414
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Site 570
S3441
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S3443
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S3461
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T3463
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S3467
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S3468
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T3510
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S3511
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S3515
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S3521
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S3529
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T3540
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Site 595
S3558
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S
S
S
E
A
H
I
Site 597
S3563
K
V
S
H
L
R
T
S
S
S
E
A
H
I
P
Site 598
S3564
V
S
H
L
R
T
S
S
S
E
A
H
I
P
D
Site 599
S3565
S
H
L
R
T
S
S
S
E
A
H
I
P
D
Q
Site 600
T3574
A
H
I
P
D
Q
E
T
T
S
L
T
S
G
T
Site 601
S3576
I
P
D
Q
E
T
T
S
L
T
S
G
T
G
T
Site 602
T3583
S
L
T
S
G
T
G
T
P
G
A
E
A
E
Q
Site 603
T3593
A
E
A
E
Q
Q
D
T
A
S
V
E
Q
S
S
Site 604
S3595
A
E
Q
Q
D
T
A
S
V
E
Q
S
S
Q
K
Site 605
S3599
D
T
A
S
V
E
Q
S
S
Q
K
E
C
G
Q
Site 606
T3620
V
L
P
E
V
Q
V
T
Q
N
P
A
N
E
Q
Site 607
T3634
Q
E
S
A
E
P
K
T
V
E
E
E
E
S
N
Site 608
S3640
K
T
V
E
E
E
E
S
N
F
S
S
P
L
M
Site 609
S3643
E
E
E
E
S
N
F
S
S
P
L
M
L
W
L
Site 610
S3644
E
E
E
S
N
F
S
S
P
L
M
L
W
L
Q
Site 611
S3659
Q
E
Q
K
R
K
E
S
I
T
E
K
K
P
K
Site 612
T3661
Q
K
R
K
E
S
I
T
E
K
K
P
K
K
G
Site 613
S3692
S
I
E
D
A
W
K
S
L
T
D
K
V
Q
E
Site 614
S3702
D
K
V
Q
E
A
R
S
N
A
R
L
K
Q
L
Site 615
S3735
V
F
L
I
E
Q
L
S
G
A
K
H
C
R
N
Site 616
Y3743
G
A
K
H
C
R
N
Y
K
F
R
F
H
K
P
Site 617
S3763
P
P
L
N
P
H
G
S
A
R
A
E
V
H
L
Site 618
S3783
D
M
F
N
F
L
A
S
K
H
R
Q
P
P
E
Site 619
Y3791
K
H
R
Q
P
P
E
Y
N
P
N
D
E
E
E
Site 620
S3805
E
E
E
V
Q
L
K
S
A
R
R
A
T
S
M
Site 621
T3810
L
K
S
A
R
R
A
T
S
M
D
L
P
M
P
Site 622
S3811
K
S
A
R
R
A
T
S
M
D
L
P
M
P
M
Site 623
T3826
R
F
R
H
L
K
K
T
S
K
E
A
V
G
V
Site 624
S3827
F
R
H
L
K
K
T
S
K
E
A
V
G
V
Y
Site 625
Y3834
S
K
E
A
V
G
V
Y
R
S
P
I
H
G
R
Site 626
S3836
E
A
V
G
V
Y
R
S
P
I
H
G
R
G
L
Site 627
Y3874
Q
T
D
K
R
E
K
Y
Y
D
S
K
G
I
G
Site 628
Y3875
T
D
K
R
E
K
Y
Y
D
S
K
G
I
G
C
Site 629
Y3914
H
S
C
E
P
N
C
Y
S
R
V
I
N
I
D
Site 630
Y3935
I
F
A
M
R
K
I
Y
R
G
E
E
L
T
Y
Site 631
T3941
I
Y
R
G
E
E
L
T
Y
D
Y
K
F
P
I
Site 632
Y3942
Y
R
G
E
E
L
T
Y
D
Y
K
F
P
I
E
Site 633
Y3944
G
E
E
L
T
Y
D
Y
K
F
P
I
E
D
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation