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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DST
Full Name:
Dystonin
Alias:
230 kDa bullous pemphigoid antigen; BPA; Hemidesmosomal plaque protein
Type:
Mass (Da):
372210
Number AA:
3214
UniProt ID:
Q03001
International Prot ID:
IPI00217992
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005604
GO:0016023
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0051015
GO:0005509
GO:0005178
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
GO:0007155
GO:0007229
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
C
P
L
P
L
V
A
S
A
G
H
H
R
H
H
Site 2
S54
Q
A
P
E
R
E
A
S
D
E
I
V
F
S
G
Site 3
S60
A
S
D
E
I
V
F
S
G
R
S
R
S
R
D
Site 4
S65
V
F
S
G
R
S
R
S
R
D
A
V
L
R
S
Site 5
S72
S
R
D
A
V
L
R
S
H
H
F
R
S
E
G
Site 6
S83
R
S
E
G
F
R
A
S
P
R
H
L
R
R
R
Site 7
S112
V
V
E
V
H
H
Q
S
E
Q
E
T
S
V
R
Site 8
S117
H
Q
S
E
Q
E
T
S
V
R
K
R
R
I
K
Site 9
S126
R
K
R
R
I
K
K
S
S
R
V
Q
P
E
F
Site 10
S127
K
R
R
I
K
K
S
S
R
V
Q
P
E
F
Y
Site 11
Y134
S
R
V
Q
P
E
F
Y
H
S
V
Q
G
A
S
Site 12
S136
V
Q
P
E
F
Y
H
S
V
Q
G
A
S
I
R
Site 13
S141
Y
H
S
V
Q
G
A
S
I
R
R
P
S
S
G
Site 14
S146
G
A
S
I
R
R
P
S
S
G
N
A
S
Y
R
Site 15
S147
A
S
I
R
R
P
S
S
G
N
A
S
Y
R
C
Site 16
S151
R
P
S
S
G
N
A
S
Y
R
C
S
M
S
S
Site 17
Y152
P
S
S
G
N
A
S
Y
R
C
S
M
S
S
S
Site 18
S155
G
N
A
S
Y
R
C
S
M
S
S
S
A
D
F
Site 19
S157
A
S
Y
R
C
S
M
S
S
S
A
D
F
S
D
Site 20
S158
S
Y
R
C
S
M
S
S
S
A
D
F
S
D
E
Site 21
S159
Y
R
C
S
M
S
S
S
A
D
F
S
D
E
D
Site 22
S163
M
S
S
S
A
D
F
S
D
E
D
D
F
S
Q
Site 23
S169
F
S
D
E
D
D
F
S
Q
K
S
G
S
A
S
Site 24
S172
E
D
D
F
S
Q
K
S
G
S
A
S
P
A
P
Site 25
S174
D
F
S
Q
K
S
G
S
A
S
P
A
P
G
D
Site 26
S176
S
Q
K
S
G
S
A
S
P
A
P
G
D
T
L
Site 27
T182
A
S
P
A
P
G
D
T
L
P
W
N
L
P
K
Site 28
S193
N
L
P
K
H
E
R
S
K
R
K
I
Q
G
G
Site 29
T732
S
G
M
T
S
R
L
T
P
S
V
T
P
A
Y
Site 30
S837
R
A
I
E
E
F
E
S
S
L
K
E
A
K
I
Site 31
S866
E
K
L
H
R
L
E
S
Q
Y
A
K
L
L
F
Site 32
Y868
L
H
R
L
E
S
Q
Y
A
K
L
L
F
S
L
Site 33
S874
Q
Y
A
K
L
L
F
S
L
L
K
N
T
S
R
Site 34
S880
F
S
L
L
K
N
T
S
R
N
Q
E
R
H
L
Site 35
Y1039
Y
S
A
T
V
K
D
Y
E
L
Q
T
M
T
Y
Site 36
S1063
E
E
L
L
Q
Y
K
S
T
I
A
N
L
M
G
Site 37
S1193
E
I
D
R
I
R
A
S
N
V
A
S
V
S
M
Site 38
T1205
V
S
M
N
L
I
K
T
M
L
P
G
E
H
Q
Site 39
S1220
Q
V
L
S
N
L
Q
S
R
F
E
D
F
L
E
Site 40
T1298
R
L
I
R
Q
I
R
T
P
L
E
R
D
D
L
Site 41
T1372
Q
V
Y
S
M
S
S
T
Y
I
D
K
Y
V
T
Site 42
S1679
I
K
R
C
K
E
T
S
E
H
G
A
Y
S
D
Site 43
Y1684
E
T
S
E
H
G
A
Y
S
D
L
L
Q
R
Q
Site 44
S1706
S
K
L
T
G
K
I
S
E
L
E
R
M
V
A
Site 45
S1720
A
E
L
K
K
Q
K
S
R
V
E
E
E
L
P
Site 46
S1748
Q
R
N
V
E
D
I
S
L
Q
K
I
R
A
E
Site 47
S1756
L
Q
K
I
R
A
E
S
E
A
K
Q
Y
R
R
Site 48
Y1761
A
E
S
E
A
K
Q
Y
R
R
E
L
E
T
I
Site 49
T1767
Q
Y
R
R
E
L
E
T
I
V
R
E
K
E
A
Site 50
T1786
L
E
R
V
R
Q
L
T
I
E
A
E
A
K
R
Site 51
T1811
R
N
Q
L
E
E
N
T
F
T
R
R
T
L
E
Site 52
T1813
Q
L
E
E
N
T
F
T
R
R
T
L
E
D
H
Site 53
T1816
E
N
T
F
T
R
R
T
L
E
D
H
L
K
R
Site 54
S1827
H
L
K
R
K
D
L
S
L
N
D
L
E
Q
Q
Site 55
T1889
L
E
A
R
R
K
I
T
E
I
Q
Y
T
C
R
Site 56
Y1893
R
K
I
T
E
I
Q
Y
T
C
R
E
N
A
L
Site 57
T1894
K
I
T
E
I
Q
Y
T
C
R
E
N
A
L
P
Site 58
T1915
A
T
S
C
R
A
V
T
G
L
Q
Q
E
H
D
Site 59
T1951
E
Q
D
M
R
E
L
T
Y
E
L
N
A
L
Q
Site 60
T1962
N
A
L
Q
L
E
K
T
S
S
E
E
K
A
R
Site 61
S1964
L
Q
L
E
K
T
S
S
E
E
K
A
R
L
L
Site 62
T1978
L
K
D
K
L
D
E
T
N
N
T
L
R
C
L
Site 63
T1981
K
L
D
E
T
N
N
T
L
R
C
L
K
L
E
Site 64
S2000
D
Q
A
E
K
G
Y
S
Q
Q
L
R
E
L
G
Site 65
T2013
L
G
R
Q
L
N
Q
T
T
G
K
A
E
E
A
Site 66
Y2034
L
K
K
I
K
R
N
Y
Q
L
E
L
E
S
L
Site 67
T2056
Q
R
E
V
D
R
I
T
R
A
H
A
V
A
E
Site 68
S2071
K
N
I
Q
H
L
N
S
Q
I
H
S
F
R
D
Site 69
S2075
H
L
N
S
Q
I
H
S
F
R
D
E
K
E
L
Site 70
S2092
L
Q
I
C
Q
R
K
S
D
H
L
K
E
Q
F
Site 71
S2102
L
K
E
Q
F
E
K
S
H
E
Q
L
L
Q
N
Site 72
S2130
L
N
E
E
L
E
K
S
N
E
C
A
E
M
L
Site 73
T2151
L
T
R
Q
N
N
E
T
K
L
M
M
Q
R
I
Site 74
S2162
M
Q
R
I
Q
A
E
S
E
N
I
V
L
E
K
Site 75
S2192
G
F
K
D
Q
L
R
S
T
N
E
H
L
H
K
Site 76
T2193
F
K
D
Q
L
R
S
T
N
E
H
L
H
K
Q
Site 77
T2203
H
L
H
K
Q
T
K
T
E
Q
D
F
Q
R
K
Site 78
S2221
L
E
E
D
L
A
K
S
Q
N
L
V
S
E
F
Site 79
S2256
L
N
A
E
L
N
A
S
K
E
E
K
R
R
G
Site 80
T2298
K
T
I
E
E
Q
M
T
H
R
K
M
V
L
F
Site 81
S2315
E
S
G
K
F
K
Q
S
A
E
E
F
R
K
K
Site 82
S2346
G
I
R
L
D
F
V
S
L
Q
Q
E
N
S
R
Site 83
S2352
V
S
L
Q
Q
E
N
S
R
A
Q
E
N
A
K
Site 84
Y2375
L
E
R
Q
L
Q
Q
Y
R
E
Q
M
Q
Q
G
Site 85
Y2390
Q
H
M
E
A
N
H
Y
Q
K
C
Q
K
L
E
Site 86
T2442
K
S
T
A
K
D
C
T
F
K
P
D
F
E
M
Site 87
S2457
T
V
K
E
C
Q
H
S
G
E
L
S
S
R
N
Site 88
S2461
C
Q
H
S
G
E
L
S
S
R
N
T
G
H
L
Site 89
T2465
G
E
L
S
S
R
N
T
G
H
L
H
P
T
P
Site 90
T2471
N
T
G
H
L
H
P
T
P
R
S
P
L
L
R
Site 91
S2474
H
L
H
P
T
P
R
S
P
L
L
R
W
T
Q
Site 92
T2480
R
S
P
L
L
R
W
T
Q
E
P
Q
P
L
E
Site 93
S2516
A
P
L
E
K
E
K
S
Q
Q
C
Y
S
E
Y
Site 94
Y2520
K
E
K
S
Q
Q
C
Y
S
E
Y
F
S
Q
T
Site 95
S2521
E
K
S
Q
Q
C
Y
S
E
Y
F
S
Q
T
S
Site 96
Y2523
S
Q
Q
C
Y
S
E
Y
F
S
Q
T
S
T
E
Site 97
S2525
Q
C
Y
S
E
Y
F
S
Q
T
S
T
E
L
Q
Site 98
T2529
E
Y
F
S
Q
T
S
T
E
L
Q
I
T
F
D
Site 99
T2534
T
S
T
E
L
Q
I
T
F
D
E
T
N
P
I
Site 100
S2545
T
N
P
I
T
R
L
S
E
I
E
K
I
R
D
Site 101
T2592
N
K
Q
Y
D
M
H
T
E
V
T
T
L
K
Q
Site 102
S2618
M
L
E
G
C
R
A
S
G
G
L
K
K
G
D
Site 103
T2635
K
K
G
L
E
P
E
T
F
Q
N
F
D
G
D
Site 104
S2646
F
D
G
D
H
A
C
S
V
R
D
D
E
F
K
Site 105
T2660
K
F
Q
G
L
R
H
T
V
T
A
R
Q
L
V
Site 106
T2662
Q
G
L
R
H
T
V
T
A
R
Q
L
V
E
A
Site 107
T2676
A
K
L
L
D
M
R
T
I
E
Q
L
R
L
G
Site 108
T2686
Q
L
R
L
G
L
K
T
V
E
E
V
Q
K
T
Site 109
T2693
T
V
E
E
V
Q
K
T
L
N
K
F
L
T
K
Site 110
T2699
K
T
L
N
K
F
L
T
K
A
T
S
I
A
G
Site 111
Y2708
A
T
S
I
A
G
L
Y
L
E
S
T
K
E
K
Site 112
T2712
A
G
L
Y
L
E
S
T
K
E
K
I
S
F
A
Site 113
S2717
E
S
T
K
E
K
I
S
F
A
S
A
A
E
R
Site 114
S2755
P
I
S
G
Q
T
Y
S
V
E
D
A
V
L
K
Site 115
Y2783
A
E
K
A
A
V
G
Y
S
Y
S
S
K
T
L
Site 116
S2784
E
K
A
A
V
G
Y
S
Y
S
S
K
T
L
S
Site 117
Y2785
K
A
A
V
G
Y
S
Y
S
S
K
T
L
S
V
Site 118
S2787
A
V
G
Y
S
Y
S
S
K
T
L
S
V
F
Q
Site 119
T2789
G
Y
S
Y
S
S
K
T
L
S
V
F
Q
A
M
Site 120
S2791
S
Y
S
S
K
T
L
S
V
F
Q
A
M
E
N
Site 121
S2852
Q
F
L
H
E
P
S
S
N
T
R
V
F
P
N
Site 122
Y2867
P
N
N
K
Q
A
L
Y
Y
S
E
L
L
R
M
Site 123
T2901
S
N
L
N
V
K
K
T
H
R
I
S
V
V
D
Site 124
S2905
V
K
K
T
H
R
I
S
V
V
D
T
K
T
G
Site 125
T2909
H
R
I
S
V
V
D
T
K
T
G
S
E
L
T
Site 126
Y2918
T
G
S
E
L
T
V
Y
E
A
F
Q
R
N
L
Site 127
S2929
Q
R
N
L
I
E
K
S
I
Y
L
E
L
S
G
Site 128
Y2931
N
L
I
E
K
S
I
Y
L
E
L
S
G
Q
Q
Site 129
S2935
K
S
I
Y
L
E
L
S
G
Q
Q
Y
Q
W
K
Site 130
Y2939
L
E
L
S
G
Q
Q
Y
Q
W
K
E
A
M
F
Site 131
Y2950
E
A
M
F
F
E
S
Y
G
H
S
S
H
M
L
Site 132
S2953
F
F
E
S
Y
G
H
S
S
H
M
L
T
D
T
Site 133
T2958
G
H
S
S
H
M
L
T
D
T
K
T
G
L
H
Site 134
T2960
S
S
H
M
L
T
D
T
K
T
G
L
H
F
N
Site 135
Y2985
D
K
A
L
V
K
K
Y
Q
E
G
L
I
T
L
Site 136
T2991
K
Y
Q
E
G
L
I
T
L
T
E
L
A
D
S
Site 137
S3011
V
P
K
K
D
L
H
S
P
V
A
G
Y
W
L
Site 138
T3019
P
V
A
G
Y
W
L
T
A
S
G
E
R
I
S
Site 139
S3026
T
A
S
G
E
R
I
S
V
L
K
A
S
R
R
Site 140
S3031
R
I
S
V
L
K
A
S
R
R
N
L
V
D
R
Site 141
T3059
G
G
I
I
D
P
L
T
G
K
K
Y
R
V
A
Site 142
Y3063
D
P
L
T
G
K
K
Y
R
V
A
E
A
L
H
Site 143
S3140
P
Q
V
H
S
R
L
S
I
E
E
A
L
Q
V
Site 144
S3163
T
K
L
K
D
Q
K
S
Y
V
R
N
I
I
C
Site 145
Y3164
K
L
K
D
Q
K
S
Y
V
R
N
I
I
C
P
Site 146
T3173
R
N
I
I
C
P
Q
T
K
R
K
L
T
Y
K
Site 147
T3178
P
Q
T
K
R
K
L
T
Y
K
E
A
L
E
K
Site 148
T3192
K
A
D
F
D
F
H
T
G
L
K
L
L
E
V
Site 149
S3208
E
P
L
M
T
G
I
S
S
L
Y
Y
S
S
_
Site 150
T3463
L
Q
V
Q
K
T
F
T
M
E
I
L
R
H
R
Site 151
T5004
P
Q
V
P
A
T
T
T
P
K
I
L
H
P
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation