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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CFHR3
Full Name:
Complement factor H-related protein 3
Alias:
DOWN16;H factor-like protein 3
Type:
Mass (Da):
37323
Number AA:
330
UniProt ID:
Q02985
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y42
H
E
N
M
R
R
P
Y
F
P
V
A
V
G
K
Site 2
Y53
A
V
G
K
Y
Y
S
Y
Y
C
D
E
H
F
E
Site 3
Y54
V
G
K
Y
Y
S
Y
Y
C
D
E
H
F
E
T
Site 4
T61
Y
C
D
E
H
F
E
T
P
S
G
S
Y
W
D
Site 5
Y88
V
P
C
L
R
K
C
Y
F
P
Y
L
E
N
G
Site 6
Y91
L
R
K
C
Y
F
P
Y
L
E
N
G
Y
N
Q
Site 7
Y96
F
P
Y
L
E
N
G
Y
N
Q
N
Y
G
R
K
Site 8
Y100
E
N
G
Y
N
Q
N
Y
G
R
K
F
V
Q
G
Site 9
S109
R
K
F
V
Q
G
N
S
T
E
V
A
C
H
P
Site 10
Y118
E
V
A
C
H
P
G
Y
G
L
P
K
A
Q
T
Site 11
T128
P
K
A
Q
T
T
V
T
C
T
E
K
G
W
S
Site 12
S135
T
C
T
E
K
G
W
S
P
T
P
R
C
I
R
Site 13
T137
T
E
K
G
W
S
P
T
P
R
C
I
R
V
R
Site 14
T145
P
R
C
I
R
V
R
T
C
S
K
S
D
I
E
Site 15
S147
C
I
R
V
R
T
C
S
K
S
D
I
E
I
E
Site 16
S149
R
V
R
T
C
S
K
S
D
I
E
I
E
N
G
Site 17
S159
E
I
E
N
G
F
I
S
E
S
S
S
I
Y
I
Site 18
S161
E
N
G
F
I
S
E
S
S
S
I
Y
I
L
N
Site 19
S163
G
F
I
S
E
S
S
S
I
Y
I
L
N
K
E
Site 20
Y165
I
S
E
S
S
S
I
Y
I
L
N
K
E
I
Q
Site 21
Y173
I
L
N
K
E
I
Q
Y
K
C
K
P
G
Y
A
Site 22
Y179
Q
Y
K
C
K
P
G
Y
A
T
A
D
G
N
S
Site 23
S189
A
D
G
N
S
S
G
S
I
T
C
L
Q
N
G
Site 24
T191
G
N
S
S
G
S
I
T
C
L
Q
N
G
W
S
Site 25
S206
A
Q
P
I
C
I
N
S
S
E
K
C
G
P
P
Site 26
S207
Q
P
I
C
I
N
S
S
E
K
C
G
P
P
P
Site 27
S217
C
G
P
P
P
P
I
S
N
G
D
T
T
S
F
Site 28
T221
P
P
I
S
N
G
D
T
T
S
F
L
L
K
V
Site 29
Y237
V
P
Q
S
R
V
E
Y
Q
C
Q
P
Y
Y
E
Site 30
Y242
V
E
Y
Q
C
Q
P
Y
Y
E
L
Q
G
S
N
Site 31
Y243
E
Y
Q
C
Q
P
Y
Y
E
L
Q
G
S
N
Y
Site 32
Y250
Y
E
L
Q
G
S
N
Y
V
T
C
S
N
G
E
Site 33
T252
L
Q
G
S
N
Y
V
T
C
S
N
G
E
W
S
Site 34
S254
G
S
N
Y
V
T
C
S
N
G
E
W
S
E
P
Site 35
S286
N
I
K
L
K
G
R
S
D
R
K
Y
Y
A
K
Site 36
Y290
K
G
R
S
D
R
K
Y
Y
A
K
T
G
D
T
Site 37
Y291
G
R
S
D
R
K
Y
Y
A
K
T
G
D
T
I
Site 38
S314
N
A
N
T
S
I
L
S
F
Q
A
V
C
R
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation