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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FKBP4
Full Name:
Peptidyl-prolyl cis-trans isomerase FKBP4
Alias:
EC 5.2.1.8; FKB4; FKBP52; FKBP59; HBI; HSP binding immunophilin; HSP56; P59; Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase
Type:
Chaperone protein
Mass (Da):
51805
Number AA:
459
UniProt ID:
Q02790
International Prot ID:
IPI00219005
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005528
GO:0031072
GO:0003755
PhosphoSite+
KinaseNET
Biological Process:
GO:0006457
Phosida
TranscriptoNet
STRING
Kinexus Products
Peptidyl-prolyl cis-trans isomerase FKBP4 pan-specific antibody AB-NN127#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN127
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
T
A
E
E
M
K
A
T
E
S
G
A
Q
S
A
Site 2
S11
E
E
M
K
A
T
E
S
G
A
Q
S
A
P
L
Site 3
S15
A
T
E
S
G
A
Q
S
A
P
L
P
M
E
G
Site 4
S26
P
M
E
G
V
D
I
S
P
K
Q
D
E
G
V
Site 5
T42
K
V
I
K
R
E
G
T
G
T
E
M
P
M
I
Site 6
T44
I
K
R
E
G
T
G
T
E
M
P
M
I
G
D
Site 7
Y57
G
D
R
V
F
V
H
Y
T
G
W
L
L
D
G
Site 8
T65
T
G
W
L
L
D
G
T
K
F
D
S
S
L
D
Site 9
S69
L
D
G
T
K
F
D
S
S
L
D
R
K
D
K
Site 10
S70
D
G
T
K
F
D
S
S
L
D
R
K
D
K
F
Site 11
S78
L
D
R
K
D
K
F
S
F
D
L
G
K
G
E
Site 12
Y111
H
I
T
C
K
P
E
Y
A
Y
G
S
A
G
S
Site 13
Y113
T
C
K
P
E
Y
A
Y
G
S
A
G
S
P
P
Site 14
S115
K
P
E
Y
A
Y
G
S
A
G
S
P
P
K
I
Site 15
S118
Y
A
Y
G
S
A
G
S
P
P
K
I
P
P
N
Site 16
T143
E
F
K
G
E
D
L
T
E
E
E
D
G
G
I
Site 17
T156
G
I
I
R
R
I
Q
T
R
G
E
G
Y
A
K
Site 18
Y161
I
Q
T
R
G
E
G
Y
A
K
P
N
E
G
A
Site 19
Y202
G
E
N
L
D
L
P
Y
G
L
E
R
A
I
Q
Site 20
S217
R
M
E
K
G
E
H
S
I
V
Y
L
K
P
S
Site 21
Y220
K
G
E
H
S
I
V
Y
L
K
P
S
Y
A
F
Site 22
Y225
I
V
Y
L
K
P
S
Y
A
F
G
S
V
G
K
Site 23
Y245
P
P
N
A
E
L
K
Y
E
L
H
L
K
S
F
Site 24
S251
K
Y
E
L
H
L
K
S
F
E
K
A
K
E
S
Site 25
S258
S
F
E
K
A
K
E
S
W
E
M
N
S
E
E
Site 26
S263
K
E
S
W
E
M
N
S
E
E
K
L
E
Q
S
Site 27
T278
T
I
V
K
E
R
G
T
V
Y
F
K
E
G
K
Site 28
Y280
V
K
E
R
G
T
V
Y
F
K
E
G
K
Y
K
Site 29
Y286
V
Y
F
K
E
G
K
Y
K
Q
A
L
L
Q
Y
Site 30
Y293
Y
K
Q
A
L
L
Q
Y
K
K
I
V
S
W
L
Site 31
S298
L
Q
Y
K
K
I
V
S
W
L
E
Y
E
S
S
Site 32
Y302
K
I
V
S
W
L
E
Y
E
S
S
F
S
N
E
Site 33
S305
S
W
L
E
Y
E
S
S
F
S
N
E
E
A
Q
Site 34
S307
L
E
Y
E
S
S
F
S
N
E
E
A
Q
K
A
Site 35
S350
N
K
A
L
E
L
D
S
N
N
E
K
G
L
F
Site 36
Y383
F
Q
K
V
L
Q
L
Y
P
N
N
K
A
A
K
Site 37
Y411
L
A
R
E
K
K
L
Y
A
N
M
F
E
R
L
Site 38
S430
N
K
A
K
A
E
A
S
S
G
D
H
P
T
D
Site 39
S431
K
A
K
A
E
A
S
S
G
D
H
P
T
D
T
Site 40
T436
A
S
S
G
D
H
P
T
D
T
E
M
K
E
E
Site 41
T438
S
G
D
H
P
T
D
T
E
M
K
E
E
Q
K
Site 42
S446
E
M
K
E
E
Q
K
S
N
T
A
G
S
Q
S
Site 43
T448
K
E
E
Q
K
S
N
T
A
G
S
Q
S
Q
V
Site 44
S451
Q
K
S
N
T
A
G
S
Q
S
Q
V
E
T
E
Site 45
S453
S
N
T
A
G
S
Q
S
Q
V
E
T
E
A
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation