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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IRF-8
Full Name:
Interferon regulatory factor 8
Alias:
ICSBP; ICSBP1; Interferon consensus sequence-binding; Interferon consensus sequence-binding protein
Type:
Transcription factor
Mass (Da):
48356
Number AA:
426
UniProt ID:
Q02556
International Prot ID:
IPI00026224
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003705
PhosphoSite+
KinaseNET
Biological Process:
GO:0006955
GO:0000122
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y23
E
Q
I
D
S
S
M
Y
P
G
L
I
W
E
N
Site 2
Y48
K
H
A
G
K
Q
D
Y
N
Q
E
V
D
A
S
Site 3
S89
L
R
C
A
L
N
K
S
P
D
F
E
E
V
T
Site 4
T96
S
P
D
F
E
E
V
T
D
R
S
Q
L
D
I
Site 5
S99
F
E
E
V
T
D
R
S
Q
L
D
I
S
E
P
Site 6
S104
D
R
S
Q
L
D
I
S
E
P
Y
K
V
Y
R
Site 7
Y107
Q
L
D
I
S
E
P
Y
K
V
Y
R
I
V
P
Site 8
Y110
I
S
E
P
Y
K
V
Y
R
I
V
P
E
E
E
Site 9
T134
A
G
C
V
N
E
V
T
E
M
E
C
G
R
S
Site 10
S141
T
E
M
E
C
G
R
S
E
I
D
E
L
I
K
Site 11
S151
D
E
L
I
K
E
P
S
V
D
D
Y
M
G
M
Site 12
Y155
K
E
P
S
V
D
D
Y
M
G
M
I
K
R
S
Site 13
S162
Y
M
G
M
I
K
R
S
P
S
P
P
E
A
C
Site 14
S164
G
M
I
K
R
S
P
S
P
P
E
A
C
R
S
Site 15
S171
S
P
P
E
A
C
R
S
Q
L
L
P
D
W
W
Site 16
T184
W
W
A
Q
Q
P
S
T
G
V
P
L
V
T
G
Site 17
Y195
L
V
T
G
Y
T
T
Y
D
A
H
H
S
A
F
Site 18
Y211
Q
M
V
I
S
F
Y
Y
G
G
K
L
V
G
Q
Site 19
T221
K
L
V
G
Q
A
T
T
T
C
P
E
G
C
R
Site 20
S230
C
P
E
G
C
R
L
S
L
S
Q
P
G
L
P
Site 21
S232
E
G
C
R
L
S
L
S
Q
P
G
L
P
G
T
Site 22
T239
S
Q
P
G
L
P
G
T
K
L
Y
G
P
E
G
Site 23
Y242
G
L
P
G
T
K
L
Y
G
P
E
G
L
E
L
Site 24
S260
P
P
A
D
A
I
P
S
E
R
Q
R
Q
V
T
Site 25
T267
S
E
R
Q
R
Q
V
T
R
K
L
F
G
H
L
Site 26
S282
E
R
G
V
L
L
H
S
S
R
Q
G
V
F
V
Site 27
T324
E
V
V
Q
V
F
D
T
S
Q
F
F
R
E
L
Site 28
S325
V
V
Q
V
F
D
T
S
Q
F
F
R
E
L
Q
Site 29
Y335
F
R
E
L
Q
Q
F
Y
N
S
Q
G
R
L
P
Site 30
S337
E
L
Q
Q
F
Y
N
S
Q
G
R
L
P
D
G
Site 31
Y373
L
V
Q
I
E
Q
L
Y
V
R
Q
L
A
E
E
Site 32
S389
G
K
S
C
G
A
G
S
V
M
Q
A
P
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation