KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SP4
Full Name:
Transcription factor Sp4
Alias:
SPR-1
Type:
Transcription protein
Mass (Da):
81985
Number AA:
784
UniProt ID:
Q02446
International Prot ID:
IPI00025805
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003702
GO:0003713
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006357
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T25
M
A
T
E
G
G
K
T
S
E
P
E
N
N
N
Site 2
T37
N
N
N
K
K
P
K
T
S
G
S
Q
D
S
Q
Site 3
S40
K
K
P
K
T
S
G
S
Q
D
S
Q
P
S
P
Site 4
S43
K
T
S
G
S
Q
D
S
Q
P
S
P
L
A
L
Site 5
S46
G
S
Q
D
S
Q
P
S
P
L
A
L
L
A
A
Site 6
T60
A
T
C
S
K
I
G
T
P
G
E
N
Q
A
T
Site 7
T95
Q
Q
L
E
L
V
T
T
Q
L
A
G
N
A
W
Site 8
T108
A
W
Q
L
V
A
S
T
P
P
A
S
K
E
N
Site 9
S112
V
A
S
T
P
P
A
S
K
E
N
N
V
S
Q
Site 10
S118
A
S
K
E
N
N
V
S
Q
P
A
S
S
S
S
Site 11
S122
N
N
V
S
Q
P
A
S
S
S
S
S
S
S
S
Site 12
S123
N
V
S
Q
P
A
S
S
S
S
S
S
S
S
S
Site 13
S124
V
S
Q
P
A
S
S
S
S
S
S
S
S
S
N
Site 14
S125
S
Q
P
A
S
S
S
S
S
S
S
S
S
N
N
Site 15
S126
Q
P
A
S
S
S
S
S
S
S
S
S
N
N
G
Site 16
S127
P
A
S
S
S
S
S
S
S
S
S
N
N
G
S
Site 17
S128
A
S
S
S
S
S
S
S
S
S
N
N
G
S
A
Site 18
S129
S
S
S
S
S
S
S
S
S
N
N
G
S
A
S
Site 19
S130
S
S
S
S
S
S
S
S
N
N
G
S
A
S
P
Site 20
S134
S
S
S
S
N
N
G
S
A
S
P
T
K
T
K
Site 21
S136
S
S
N
N
G
S
A
S
P
T
K
T
K
S
G
Site 22
T138
N
N
G
S
A
S
P
T
K
T
K
S
G
N
S
Site 23
T140
G
S
A
S
P
T
K
T
K
S
G
N
S
S
T
Site 24
S142
A
S
P
T
K
T
K
S
G
N
S
S
T
P
G
Site 25
S146
K
T
K
S
G
N
S
S
T
P
G
Q
F
Q
V
Site 26
T147
T
K
S
G
N
S
S
T
P
G
Q
F
Q
V
I
Site 27
T173
Q
V
I
P
Q
L
Q
T
V
E
G
Q
Q
I
Q
Site 28
T184
Q
Q
I
Q
I
N
P
T
S
S
S
S
L
Q
D
Site 29
S185
Q
I
Q
I
N
P
T
S
S
S
S
L
Q
D
L
Site 30
S188
I
N
P
T
S
S
S
S
L
Q
D
L
Q
G
Q
Site 31
S216
T
A
A
N
R
T
A
S
G
N
I
L
A
Q
N
Site 32
T245
S
I
P
L
Q
L
Q
T
L
P
G
T
Q
A
Q
Site 33
S292
Q
P
A
A
T
A
D
S
G
T
S
N
G
N
Q
Site 34
T303
N
G
N
Q
L
V
S
T
P
T
N
T
T
T
S
Site 35
T308
V
S
T
P
T
N
T
T
T
S
A
S
T
M
P
Site 36
S310
T
P
T
N
T
T
T
S
A
S
T
M
P
E
S
Site 37
S312
T
N
T
T
T
S
A
S
T
M
P
E
S
P
S
Site 38
T313
N
T
T
T
S
A
S
T
M
P
E
S
P
S
S
Site 39
S317
S
A
S
T
M
P
E
S
P
S
S
S
T
T
C
Site 40
S319
S
T
M
P
E
S
P
S
S
S
T
T
C
T
T
Site 41
S320
T
M
P
E
S
P
S
S
S
T
T
C
T
T
T
Site 42
S321
M
P
E
S
P
S
S
S
T
T
C
T
T
T
A
Site 43
T323
E
S
P
S
S
S
T
T
C
T
T
T
A
S
T
Site 44
T325
P
S
S
S
T
T
C
T
T
T
A
S
T
S
L
Site 45
T326
S
S
S
T
T
C
T
T
T
A
S
T
S
L
T
Site 46
T327
S
S
T
T
C
T
T
T
A
S
T
S
L
T
S
Site 47
S329
T
T
C
T
T
T
A
S
T
S
L
T
S
S
D
Site 48
S331
C
T
T
T
A
S
T
S
L
T
S
S
D
T
L
Site 49
T333
T
T
A
S
T
S
L
T
S
S
D
T
L
V
S
Site 50
S335
A
S
T
S
L
T
S
S
D
T
L
V
S
S
A
Site 51
T337
T
S
L
T
S
S
D
T
L
V
S
S
A
D
T
Site 52
S340
T
S
S
D
T
L
V
S
S
A
D
T
G
Q
Y
Site 53
T344
T
L
V
S
S
A
D
T
G
Q
Y
A
S
T
S
Site 54
Y347
S
S
A
D
T
G
Q
Y
A
S
T
S
A
S
S
Site 55
S349
A
D
T
G
Q
Y
A
S
T
S
A
S
S
S
E
Site 56
T350
D
T
G
Q
Y
A
S
T
S
A
S
S
S
E
R
Site 57
S351
T
G
Q
Y
A
S
T
S
A
S
S
S
E
R
T
Site 58
S353
Q
Y
A
S
T
S
A
S
S
S
E
R
T
I
E
Site 59
S355
A
S
T
S
A
S
S
S
E
R
T
I
E
E
S
Site 60
T358
S
A
S
S
S
E
R
T
I
E
E
S
Q
T
P
Site 61
S362
S
E
R
T
I
E
E
S
Q
T
P
A
A
T
E
Site 62
T364
R
T
I
E
E
S
Q
T
P
A
A
T
E
S
E
Site 63
S370
Q
T
P
A
A
T
E
S
E
A
Q
S
S
S
Q
Site 64
S374
A
T
E
S
E
A
Q
S
S
S
Q
L
Q
P
N
Site 65
S375
T
E
S
E
A
Q
S
S
S
Q
L
Q
P
N
G
Site 66
S376
E
S
E
A
Q
S
S
S
Q
L
Q
P
N
G
M
Site 67
S424
I
Q
A
I
P
P
Q
S
F
Q
L
Q
S
G
Q
Site 68
S464
R
A
P
T
L
T
P
S
G
Q
I
S
W
Q
T
Site 69
S468
L
T
P
S
G
Q
I
S
W
Q
T
V
Q
V
Q
Site 70
S479
V
Q
V
Q
N
I
Q
S
L
S
N
L
Q
V
Q
Site 71
S491
Q
V
Q
N
A
G
L
S
Q
Q
L
T
I
T
P
Site 72
T497
L
S
Q
Q
L
T
I
T
P
V
S
S
S
G
G
Site 73
T599
A
V
S
P
D
Q
L
T
Q
V
H
L
Q
Q
G
Site 74
S626
R
L
R
R
V
A
C
S
C
P
N
C
R
E
G
Site 75
S638
R
E
G
E
G
R
G
S
N
E
P
G
K
K
K
Site 76
Y658
I
E
G
C
G
K
V
Y
G
K
T
S
H
L
R
Site 77
S662
G
K
V
Y
G
K
T
S
H
L
R
A
H
L
R
Site 78
T672
R
A
H
L
R
W
H
T
G
E
R
P
F
I
C
Site 79
T689
M
F
C
G
K
R
F
T
R
S
D
E
L
Q
R
Site 80
S691
C
G
K
R
F
T
R
S
D
E
L
Q
R
H
R
Site 81
T700
E
L
Q
R
H
R
R
T
H
T
G
E
K
R
F
Site 82
T702
Q
R
H
R
R
T
H
T
G
E
K
R
F
E
C
Site 83
S719
C
S
K
R
F
M
R
S
D
H
L
S
K
H
V
Site 84
S750
T
S
G
E
L
D
S
S
V
T
E
V
L
G
S
Site 85
T752
G
E
L
D
S
S
V
T
E
V
L
G
S
P
R
Site 86
S767
I
V
T
V
A
A
I
S
Q
D
S
N
P
A
T
Site 87
S770
V
A
A
I
S
Q
D
S
N
P
A
T
P
N
V
Site 88
T774
S
Q
D
S
N
P
A
T
P
N
V
S
T
N
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation