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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DSG1
Full Name:
Desmoglein-1
Alias:
Cadherin family member 4; CDHF4; Desmoglein 1; Desmoglein-1; Desmosomal glycoprotein 1; DG1; DGI; DSG; Pemphigus foliaceus antigen
Type:
Adhesion
Mass (Da):
113748
Number AA:
1049
UniProt ID:
Q02413
International Prot ID:
IPI00025753
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0030057
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005515
GO:0015643
PhosphoSite+
KinaseNET
Biological Process:
GO:0016339
GO:0007043
GO:0007156
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y32
F
R
I
Q
V
R
D
Y
N
T
K
N
G
T
I
Site 2
S43
N
G
T
I
K
W
H
S
I
R
R
Q
K
R
E
Site 3
S65
C
R
E
G
E
D
N
S
K
R
N
P
I
A
K
Site 4
S206
I
R
Q
E
P
S
D
S
P
M
F
I
I
N
R
Site 5
T215
M
F
I
I
N
R
N
T
G
E
I
R
T
M
N
Site 6
T220
R
N
T
G
E
I
R
T
M
N
N
F
L
D
R
Site 7
S437
A
D
L
L
A
V
D
S
R
T
G
K
L
T
L
Site 8
S579
D
C
G
G
A
P
R
S
A
A
G
F
E
P
V
Site 9
S590
F
E
P
V
P
E
C
S
D
G
A
I
H
S
W
Site 10
S596
C
S
D
G
A
I
H
S
W
A
V
E
G
P
Q
Site 11
T610
Q
P
E
P
R
D
I
T
T
V
I
P
Q
I
P
Site 12
T611
P
E
P
R
D
I
T
T
V
I
P
Q
I
P
P
Site 13
S630
I
I
E
C
I
D
N
S
G
V
Y
T
N
E
Y
Site 14
Y633
C
I
D
N
S
G
V
Y
T
N
E
Y
G
G
R
Site 15
T634
I
D
N
S
G
V
Y
T
N
E
Y
G
G
R
E
Site 16
Y637
S
G
V
Y
T
N
E
Y
G
G
R
E
M
Q
D
Site 17
T652
L
G
G
G
E
R
M
T
G
F
E
L
T
E
G
Site 18
T657
R
M
T
G
F
E
L
T
E
G
V
K
T
S
G
Site 19
T662
E
L
T
E
G
V
K
T
S
G
M
P
E
I
C
Site 20
S663
L
T
E
G
V
K
T
S
G
M
P
E
I
C
Q
Site 21
Y672
M
P
E
I
C
Q
E
Y
S
G
T
L
R
R
N
Site 22
T675
I
C
Q
E
Y
S
G
T
L
R
R
N
S
M
R
Site 23
S680
S
G
T
L
R
R
N
S
M
R
E
C
R
E
G
Site 24
S714
D
E
D
E
G
R
P
S
N
D
C
L
L
I
Y
Site 25
S746
I
G
E
D
L
D
D
S
F
L
D
T
L
G
P
Site 26
T750
L
D
D
S
F
L
D
T
L
G
P
K
F
K
K
Site 27
S762
F
K
K
L
A
D
I
S
L
G
K
E
S
Y
P
Site 28
Y768
I
S
L
G
K
E
S
Y
P
D
L
D
P
S
W
Site 29
S774
S
Y
P
D
L
D
P
S
W
P
P
Q
S
T
E
Site 30
S779
D
P
S
W
P
P
Q
S
T
E
P
V
C
L
P
Site 31
T780
P
S
W
P
P
Q
S
T
E
P
V
C
L
P
Q
Site 32
S794
Q
E
T
E
P
V
V
S
G
H
P
P
I
S
P
Site 33
S800
V
S
G
H
P
P
I
S
P
H
F
G
T
T
T
Site 34
T806
I
S
P
H
F
G
T
T
T
V
I
S
E
S
T
Site 35
T807
S
P
H
F
G
T
T
T
V
I
S
E
S
T
Y
Site 36
S810
F
G
T
T
T
V
I
S
E
S
T
Y
P
S
G
Site 37
S812
T
T
T
V
I
S
E
S
T
Y
P
S
G
P
G
Site 38
S816
I
S
E
S
T
Y
P
S
G
P
G
V
L
H
P
Site 39
T836
P
L
G
Y
G
N
V
T
V
T
E
S
Y
T
T
Site 40
T838
G
Y
G
N
V
T
V
T
E
S
Y
T
T
S
D
Site 41
S840
G
N
V
T
V
T
E
S
Y
T
T
S
D
T
L
Site 42
S844
V
T
E
S
Y
T
T
S
D
T
L
K
P
S
V
Site 43
T846
E
S
Y
T
T
S
D
T
L
K
P
S
V
H
V
Site 44
S850
T
S
D
T
L
K
P
S
V
H
V
H
D
N
R
Site 45
S860
V
H
D
N
R
P
A
S
N
V
V
V
T
E
R
Site 46
S890
M
P
D
L
R
D
G
S
N
V
I
V
T
E
R
Site 47
S902
T
E
R
V
I
A
P
S
S
S
L
P
T
S
L
Site 48
S903
E
R
V
I
A
P
S
S
S
L
P
T
S
L
T
Site 49
T907
A
P
S
S
S
L
P
T
S
L
T
I
H
H
P
Site 50
S908
P
S
S
S
L
P
T
S
L
T
I
H
H
P
R
Site 51
T910
S
S
L
P
T
S
L
T
I
H
H
P
R
E
S
Site 52
S917
T
I
H
H
P
R
E
S
S
N
V
V
V
T
E
Site 53
S918
I
H
H
P
R
E
S
S
N
V
V
V
T
E
R
Site 54
T930
T
E
R
V
I
Q
P
T
S
G
M
I
G
S
L
Site 55
S931
E
R
V
I
Q
P
T
S
G
M
I
G
S
L
S
Site 56
S936
P
T
S
G
M
I
G
S
L
S
M
H
P
E
L
Site 57
S938
S
G
M
I
G
S
L
S
M
H
P
E
L
A
N
Site 58
S1011
S
S
L
G
G
T
A
S
I
G
H
M
R
S
S
Site 59
S1017
A
S
I
G
H
M
R
S
S
S
D
H
H
F
N
Site 60
S1018
S
I
G
H
M
R
S
S
S
D
H
H
F
N
Q
Site 61
S1019
I
G
H
M
R
S
S
S
D
H
H
F
N
Q
T
Site 62
T1026
S
D
H
H
F
N
Q
T
I
G
S
A
S
P
S
Site 63
S1029
H
F
N
Q
T
I
G
S
A
S
P
S
T
A
R
Site 64
S1031
N
Q
T
I
G
S
A
S
P
S
T
A
R
S
R
Site 65
S1033
T
I
G
S
A
S
P
S
T
A
R
S
R
I
T
Site 66
T1034
I
G
S
A
S
P
S
T
A
R
S
R
I
T
K
Site 67
S1037
A
S
P
S
T
A
R
S
R
I
T
K
Y
S
T
Site 68
T1040
S
T
A
R
S
R
I
T
K
Y
S
T
V
Q
Y
Site 69
Y1042
A
R
S
R
I
T
K
Y
S
T
V
Q
Y
S
K
Site 70
S1043
R
S
R
I
T
K
Y
S
T
V
Q
Y
S
K
_
Site 71
T1044
S
R
I
T
K
Y
S
T
V
Q
Y
S
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation