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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NRG1
Full Name:
Pro-neuregulin-1, membrane-bound isoform
Alias:
acetylcholine receptor-inducing activity; ARIA; breast cancer cell differentiation factor p45; GGF; GGF2; glial growth factor; heregulin; HGL; HRG; HRG1; HRGA; NDF; Neu differentiation factor; neuregulin 1; Neuregulin-1; Pro-NRG1; sensory and motor neuron-derived factor; SMDF
Type:
Ligand, receptor tyrosine kinase
Mass (Da):
70392
Number AA:
640
UniProt ID:
Q02297
International Prot ID:
IPI00296902
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016324
GO:0005576
GO:0005615
Uniprot
OncoNet
Molecular Function:
GO:0043125
GO:0008083
GO:0030296
PhosphoSite+
KinaseNET
Biological Process:
GO:0007219
GO:0007171
GO:0006916
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S281
L
H
D
R
L
R
Q
S
L
R
S
E
R
N
N
Site 2
S284
R
L
R
Q
S
L
R
S
E
R
N
N
M
M
N
Site 3
Y312
N
V
Q
L
V
N
Q
Y
V
S
K
N
V
I
S
Site 4
S331
V
E
R
E
A
E
T
S
F
S
T
S
H
Y
T
Site 5
S333
R
E
A
E
T
S
F
S
T
S
H
Y
T
S
T
Site 6
S335
A
E
T
S
F
S
T
S
H
Y
T
S
T
A
H
Site 7
Y337
T
S
F
S
T
S
H
Y
T
S
T
A
H
H
S
Site 8
S339
F
S
T
S
H
Y
T
S
T
A
H
H
S
T
T
Site 9
T340
S
T
S
H
Y
T
S
T
A
H
H
S
T
T
V
Site 10
T346
S
T
A
H
H
S
T
T
V
T
Q
T
P
S
H
Site 11
T348
A
H
H
S
T
T
V
T
Q
T
P
S
H
S
W
Site 12
T350
H
S
T
T
V
T
Q
T
P
S
H
S
W
S
N
Site 13
S352
T
T
V
T
Q
T
P
S
H
S
W
S
N
G
H
Site 14
S354
V
T
Q
T
P
S
H
S
W
S
N
G
H
T
E
Site 15
S356
Q
T
P
S
H
S
W
S
N
G
H
T
E
S
I
Site 16
T360
H
S
W
S
N
G
H
T
E
S
I
L
S
E
S
Site 17
S362
W
S
N
G
H
T
E
S
I
L
S
E
S
H
S
Site 18
S365
G
H
T
E
S
I
L
S
E
S
H
S
V
I
V
Site 19
S375
H
S
V
I
V
M
S
S
V
E
N
S
R
H
S
Site 20
S379
V
M
S
S
V
E
N
S
R
H
S
S
P
T
G
Site 21
S382
S
V
E
N
S
R
H
S
S
P
T
G
G
P
R
Site 22
S383
V
E
N
S
R
H
S
S
P
T
G
G
P
R
G
Site 23
T385
N
S
R
H
S
S
P
T
G
G
P
R
G
R
L
Site 24
T395
P
R
G
R
L
N
G
T
G
G
P
R
E
C
N
Site 25
S403
G
G
P
R
E
C
N
S
F
L
R
H
A
R
E
Site 26
T411
F
L
R
H
A
R
E
T
P
D
S
Y
R
D
S
Site 27
S414
H
A
R
E
T
P
D
S
Y
R
D
S
P
H
S
Site 28
Y415
A
R
E
T
P
D
S
Y
R
D
S
P
H
S
E
Site 29
S418
T
P
D
S
Y
R
D
S
P
H
S
E
R
Y
V
Site 30
S421
S
Y
R
D
S
P
H
S
E
R
Y
V
S
A
M
Site 31
Y424
D
S
P
H
S
E
R
Y
V
S
A
M
T
T
P
Site 32
S426
P
H
S
E
R
Y
V
S
A
M
T
T
P
A
R
Site 33
T430
R
Y
V
S
A
M
T
T
P
A
R
M
S
P
V
Site 34
S435
M
T
T
P
A
R
M
S
P
V
D
F
H
T
P
Site 35
T441
M
S
P
V
D
F
H
T
P
S
S
P
K
S
P
Site 36
S443
P
V
D
F
H
T
P
S
S
P
K
S
P
P
S
Site 37
S444
V
D
F
H
T
P
S
S
P
K
S
P
P
S
E
Site 38
S447
H
T
P
S
S
P
K
S
P
P
S
E
M
S
P
Site 39
S450
S
S
P
K
S
P
P
S
E
M
S
P
P
V
S
Site 40
S453
K
S
P
P
S
E
M
S
P
P
V
S
S
M
T
Site 41
S457
S
E
M
S
P
P
V
S
S
M
T
V
S
M
P
Site 42
S458
E
M
S
P
P
V
S
S
M
T
V
S
M
P
S
Site 43
S469
S
M
P
S
M
A
V
S
P
F
M
E
E
E
R
Site 44
T482
E
R
P
L
L
L
V
T
P
P
R
L
R
E
K
Site 45
S509
H
H
N
P
A
H
D
S
N
S
L
P
A
S
P
Site 46
S511
N
P
A
H
D
S
N
S
L
P
A
S
P
L
R
Site 47
S515
D
S
N
S
L
P
A
S
P
L
R
I
V
E
D
Site 48
Y525
R
I
V
E
D
E
E
Y
E
T
T
Q
E
Y
E
Site 49
T527
V
E
D
E
E
Y
E
T
T
Q
E
Y
E
P
A
Site 50
T528
E
D
E
E
Y
E
T
T
Q
E
Y
E
P
A
Q
Site 51
Y531
E
Y
E
T
T
Q
E
Y
E
P
A
Q
E
P
V
Site 52
S544
P
V
K
K
L
A
N
S
R
R
A
K
R
T
K
Site 53
T550
N
S
R
R
A
K
R
T
K
P
N
G
H
I
A
Site 54
S564
A
N
R
L
E
V
D
S
N
T
S
S
Q
S
S
Site 55
T566
R
L
E
V
D
S
N
T
S
S
Q
S
S
N
S
Site 56
S567
L
E
V
D
S
N
T
S
S
Q
S
S
N
S
E
Site 57
S568
E
V
D
S
N
T
S
S
Q
S
S
N
S
E
S
Site 58
S570
D
S
N
T
S
S
Q
S
S
N
S
E
S
E
T
Site 59
S571
S
N
T
S
S
Q
S
S
N
S
E
S
E
T
E
Site 60
S573
T
S
S
Q
S
S
N
S
E
S
E
T
E
D
E
Site 61
S575
S
Q
S
S
N
S
E
S
E
T
E
D
E
R
V
Site 62
T577
S
S
N
S
E
S
E
T
E
D
E
R
V
G
E
Site 63
T586
D
E
R
V
G
E
D
T
P
F
L
G
I
Q
N
Site 64
T612
F
R
L
A
D
S
R
T
N
P
A
G
R
F
S
Site 65
S619
T
N
P
A
G
R
F
S
T
Q
E
E
I
Q
A
Site 66
T620
N
P
A
G
R
F
S
T
Q
E
E
I
Q
A
R
Site 67
S629
E
E
I
Q
A
R
L
S
S
V
I
A
N
Q
D
Site 68
S630
E
I
Q
A
R
L
S
S
V
I
A
N
Q
D
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation