KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
EXOSC10
Full Name:
Exosome component 10
Alias:
Autoantigen PM/Scl 2; EXOSX; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; P2; P3; P4; PM/Sc; PM/Scl-100; PM-Scl; PMSCL2; Polymyositis/scleroderma autoantigen 2 (100kD); RRP6; Rrp6p
Type:
Vesicle protein
Mass (Da):
100831
Number AA:
885
UniProt ID:
Q01780
International Prot ID:
IPI00009464
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0000176
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0008408
GO:0003723
GO:0042802
PhosphoSite+
KinaseNET
Biological Process:
GO:0000184
GO:0006364
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
A
P
P
S
T
R
E
P
R
V
L
S
Site 2
S13
T
R
E
P
R
V
L
S
A
T
S
A
T
K
S
Site 3
T15
E
P
R
V
L
S
A
T
S
A
T
K
S
D
G
Site 4
S16
P
R
V
L
S
A
T
S
A
T
K
S
D
G
E
Site 5
S20
S
A
T
S
A
T
K
S
D
G
E
M
V
L
P
Site 6
Y60
L
P
Q
F
G
D
E
Y
D
F
Y
R
S
F
P
Site 7
Y63
F
G
D
E
Y
D
F
Y
R
S
F
P
G
F
Q
Site 8
Y90
C
M
S
R
V
M
Q
Y
H
G
C
R
S
N
I
Site 9
S101
R
S
N
I
K
D
R
S
K
V
T
E
L
E
D
Site 10
S132
G
I
L
L
D
E
A
S
G
V
N
K
N
Q
Q
Site 11
T151
A
G
L
Q
V
P
K
T
V
V
S
S
W
N
R
Site 12
S155
V
P
K
T
V
V
S
S
W
N
R
K
A
A
E
Site 13
Y163
W
N
R
K
A
A
E
Y
G
K
K
A
K
S
E
Site 14
S169
E
Y
G
K
K
A
K
S
E
T
F
R
L
L
H
Site 15
T171
G
K
K
A
K
S
E
T
F
R
L
L
H
A
K
Site 16
S194
F
R
E
K
I
D
N
S
N
T
P
F
L
P
K
Site 17
T196
E
K
I
D
N
S
N
T
P
F
L
P
K
I
F
Site 18
S217
K
P
L
P
Q
A
L
S
K
E
R
R
E
R
P
Site 19
T266
Q
Y
E
L
N
H
F
T
P
A
D
A
V
L
Q
Site 20
Y280
Q
K
P
Q
P
Q
L
Y
R
P
I
E
E
T
P
Site 21
T286
L
Y
R
P
I
E
E
T
P
C
H
F
I
S
S
Site 22
S318
A
V
D
L
E
H
H
S
Y
R
S
F
L
G
L
Site 23
Y319
V
D
L
E
H
H
S
Y
R
S
F
L
G
L
T
Site 24
S321
L
E
H
H
S
Y
R
S
F
L
G
L
T
C
L
Site 25
T342
T
E
D
F
I
I
D
T
L
E
L
R
S
D
M
Site 26
S347
I
D
T
L
E
L
R
S
D
M
Y
I
L
N
E
Site 27
Y350
L
E
L
R
S
D
M
Y
I
L
N
E
S
L
T
Site 28
S370
K
V
F
H
G
A
D
S
D
I
E
W
L
Q
K
Site 29
Y410
L
D
H
L
L
K
L
Y
C
N
V
D
S
N
K
Site 30
Y419
N
V
D
S
N
K
Q
Y
Q
L
A
D
W
R
I
Site 31
S435
P
L
P
E
E
M
L
S
Y
A
R
D
D
T
H
Site 32
Y436
L
P
E
E
M
L
S
Y
A
R
D
D
T
H
Y
Site 33
T441
L
S
Y
A
R
D
D
T
H
Y
L
L
Y
I
Y
Site 34
Y443
Y
A
R
D
D
T
H
Y
L
L
Y
I
Y
D
K
Site 35
Y446
D
D
T
H
Y
L
L
Y
I
Y
D
K
M
R
L
Site 36
Y448
T
H
Y
L
L
Y
I
Y
D
K
M
R
L
E
M
Site 37
T487
K
F
I
K
P
I
F
T
D
E
S
Y
L
E
L
Site 38
S490
K
P
I
F
T
D
E
S
Y
L
E
L
Y
R
K
Site 39
Y491
P
I
F
T
D
E
S
Y
L
E
L
Y
R
K
Q
Site 40
Y495
D
E
S
Y
L
E
L
Y
R
K
Q
K
K
H
L
Site 41
T520
L
F
A
W
R
D
K
T
A
R
R
E
D
E
S
Site 42
S527
T
A
R
R
E
D
E
S
Y
G
Y
V
L
P
N
Site 43
Y528
A
R
R
E
D
E
S
Y
G
Y
V
L
P
N
H
Site 44
Y530
R
E
D
E
S
Y
G
Y
V
L
P
N
H
M
M
Site 45
S593
V
A
A
G
V
K
K
S
G
P
L
P
S
A
E
Site 46
S598
K
K
S
G
P
L
P
S
A
E
R
L
E
N
V
Site 47
Y620
S
H
A
P
P
D
G
Y
P
I
I
P
T
S
G
Site 48
S626
G
Y
P
I
I
P
T
S
G
S
V
P
V
Q
K
Site 49
S628
P
I
I
P
T
S
G
S
V
P
V
Q
K
Q
A
Site 50
S665
I
T
L
F
N
E
P
S
A
E
D
S
K
K
G
Site 51
S669
N
E
P
S
A
E
D
S
K
K
G
P
L
T
V
Site 52
T675
D
S
K
K
G
P
L
T
V
A
Q
K
K
A
Q
Site 53
S698
P
F
R
M
F
L
P
S
L
G
H
R
A
P
V
Site 54
S706
L
G
H
R
A
P
V
S
Q
A
A
K
F
D
P
Site 55
T715
A
A
K
F
D
P
S
T
K
I
Y
E
I
S
N
Site 56
Y718
F
D
P
S
T
K
I
Y
E
I
S
N
R
W
K
Site 57
T747
K
K
K
A
A
E
Q
T
A
A
R
E
Q
A
K
Site 58
T784
A
K
K
R
E
R
A
T
S
D
P
R
T
T
E
Site 59
S785
K
K
R
E
R
A
T
S
D
P
R
T
T
E
Q
Site 60
T789
R
A
T
S
D
P
R
T
T
E
Q
K
Q
E
K
Site 61
T790
A
T
S
D
P
R
T
T
E
Q
K
Q
E
K
K
Site 62
T816
E
P
P
E
K
E
F
T
P
Y
D
Y
S
Q
S
Site 63
Y818
P
E
K
E
F
T
P
Y
D
Y
S
Q
S
D
F
Site 64
Y820
K
E
F
T
P
Y
D
Y
S
Q
S
D
F
K
A
Site 65
S821
E
F
T
P
Y
D
Y
S
Q
S
D
F
K
A
F
Site 66
S832
F
K
A
F
A
G
N
S
K
S
K
V
S
S
Q
Site 67
S834
A
F
A
G
N
S
K
S
K
V
S
S
Q
F
D
Site 68
S838
N
S
K
S
K
V
S
S
Q
F
D
P
N
K
Q
Site 69
T846
Q
F
D
P
N
K
Q
T
P
S
G
K
K
C
I
Site 70
S861
A
A
K
K
I
K
Q
S
V
G
N
K
S
M
S
Site 71
S866
K
Q
S
V
G
N
K
S
M
S
F
P
T
G
K
Site 72
S868
S
V
G
N
K
S
M
S
F
P
T
G
K
S
D
Site 73
T871
N
K
S
M
S
F
P
T
G
K
S
D
R
G
F
Site 74
S874
M
S
F
P
T
G
K
S
D
R
G
F
R
Y
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation