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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FMO1
Full Name:
Dimethylaniline monooxygenase [N-oxide-forming] 1
Alias:
Dimethylaniline oxidase 1; Fetal hepatic flavin-containing monooxygenase 1; Flavin containing monooxygenase 1; FMO 1
Type:
Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 1.14.13.8; Oxidoreductase
Mass (Da):
60310
Number AA:
UniProt ID:
Q01740
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005788
GO:0016021
GO:0031227
Uniprot
OncoNet
Molecular Function:
GO:0050660
GO:0050661
GO:0004499
PhosphoSite+
KinaseNET
Biological Process:
GO:0006082
GO:0055114
GO:0009404
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
A
G
V
S
G
L
A
S
I
K
C
C
L
E
E
Site 2
S34
E
P
T
C
F
E
R
S
D
D
L
G
G
L
W
Site 3
T44
L
G
G
L
W
R
F
T
E
H
V
E
E
G
R
Site 4
S53
H
V
E
E
G
R
A
S
L
Y
K
S
V
V
S
Site 5
Y55
E
E
G
R
A
S
L
Y
K
S
V
V
S
N
S
Site 6
S57
G
R
A
S
L
Y
K
S
V
V
S
N
S
C
K
Site 7
S60
S
L
Y
K
S
V
V
S
N
S
C
K
E
M
S
Site 8
Y69
S
C
K
E
M
S
C
Y
S
D
F
P
F
P
E
Site 9
Y78
D
F
P
F
P
E
D
Y
P
N
Y
V
P
N
S
Site 10
Y81
F
P
E
D
Y
P
N
Y
V
P
N
S
Q
F
L
Site 11
S85
Y
P
N
Y
V
P
N
S
Q
F
L
E
Y
L
K
Site 12
Y90
P
N
S
Q
F
L
E
Y
L
K
M
Y
A
N
H
Site 13
T108
L
K
H
I
Q
F
K
T
K
V
C
S
V
T
K
Site 14
S112
Q
F
K
T
K
V
C
S
V
T
K
C
S
D
S
Site 15
S119
S
V
T
K
C
S
D
S
A
V
S
G
Q
W
E
Site 16
Y154
T
G
F
L
T
N
P
Y
L
P
L
D
S
F
P
Site 17
Y170
I
N
A
F
K
G
Q
Y
F
H
S
R
Q
Y
K
Site 18
Y176
Q
Y
F
H
S
R
Q
Y
K
H
P
D
I
F
K
Site 19
S222
T
G
G
G
W
V
I
S
R
I
F
D
S
G
Y
Site 20
S246
F
Q
N
M
L
R
N
S
L
P
T
P
I
V
T
Site 21
Y269
N
W
L
N
H
A
N
Y
G
L
I
P
E
D
R
Site 22
T277
G
L
I
P
E
D
R
T
Q
L
K
E
F
V
L
Site 23
S302
G
K
V
F
I
R
P
S
I
K
E
V
K
E
N
Site 24
S310
I
K
E
V
K
E
N
S
V
I
F
N
N
T
S
Site 25
S317
S
V
I
F
N
N
T
S
K
E
E
P
I
D
I
Site 26
S351
K
V
E
D
G
Q
A
S
L
Y
K
Y
I
F
P
Site 27
Y353
E
D
G
Q
A
S
L
Y
K
Y
I
F
P
A
H
Site 28
Y355
G
Q
A
S
L
Y
K
Y
I
F
P
A
H
L
Q
Site 29
T381
P
L
G
S
M
I
P
T
G
E
T
Q
A
R
W
Site 30
S403
V
N
K
L
P
P
P
S
V
M
I
E
E
I
N
Site 31
Y424
P
S
W
F
G
L
C
Y
C
K
A
L
Q
S
D
Site 32
Y432
C
K
A
L
Q
S
D
Y
I
T
Y
I
D
E
L
Site 33
Y442
Y
I
D
E
L
L
T
Y
I
N
A
K
P
N
L
Site 34
Y471
F
F
G
P
C
S
P
Y
Q
F
R
L
T
G
P
Site 35
T476
S
P
Y
Q
F
R
L
T
G
P
G
K
W
E
G
Site 36
T495
I
M
T
Q
W
D
R
T
F
K
V
I
K
A
R
Site 37
S507
K
A
R
V
V
Q
E
S
P
S
P
F
E
S
F
Site 38
S509
R
V
V
Q
E
S
P
S
P
F
E
S
F
L
K
Site 39
S513
E
S
P
S
P
F
E
S
F
L
K
V
F
S
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation