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Updated November 2019
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Protein Info
Short Name:
PLPB1
Full Name:
Myelin transcription factor 1
Alias:
MTF1; MYT1; MYTI; Proteolipid protein-binding
Type:
Transcription factor
Mass (Da):
122330
Number AA:
UniProt ID:
Q01538
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0003700
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0007399
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
N
E
D
K
R
A
R
T
R
S
K
A
L
R
G
Site 2
S14
D
K
R
A
R
T
R
S
K
A
L
R
G
P
P
Site 3
T23
A
L
R
G
P
P
E
T
T
A
A
D
L
S
C
Site 4
S29
E
T
T
A
A
D
L
S
C
P
T
P
G
C
T
Site 5
T32
A
A
D
L
S
C
P
T
P
G
C
T
G
S
G
Site 6
S38
P
T
P
G
C
T
G
S
G
H
V
R
G
K
Y
Site 7
Y45
S
G
H
V
R
G
K
Y
S
R
H
R
S
L
Q
Site 8
S46
G
H
V
R
G
K
Y
S
R
H
R
S
L
Q
S
Site 9
S50
G
K
Y
S
R
H
R
S
L
Q
S
C
P
L
A
Site 10
S72
A
E
A
E
H
L
V
S
K
R
K
S
H
P
L
Site 11
S76
H
L
V
S
K
R
K
S
H
P
L
K
L
A
L
Site 12
Y87
K
L
A
L
D
E
G
Y
G
V
D
S
D
G
S
Site 13
S91
D
E
G
Y
G
V
D
S
D
G
S
E
D
T
E
Site 14
S94
Y
G
V
D
S
D
G
S
E
D
T
E
V
K
D
Site 15
S103
D
T
E
V
K
D
A
S
V
S
D
E
S
E
G
Site 16
S105
E
V
K
D
A
S
V
S
D
E
S
E
G
T
L
Site 17
T111
V
S
D
E
S
E
G
T
L
E
G
A
E
A
E
Site 18
S120
E
G
A
E
A
E
T
S
G
Q
D
E
I
H
R
Site 19
T130
D
E
I
H
R
P
E
T
A
E
G
R
S
P
V
Site 20
S135
P
E
T
A
E
G
R
S
P
V
K
S
H
F
G
Site 21
S139
E
G
R
S
P
V
K
S
H
F
G
S
N
P
I
Site 22
S143
P
V
K
S
H
F
G
S
N
P
I
G
S
A
T
Site 23
S148
F
G
S
N
P
I
G
S
A
T
A
S
S
K
G
Site 24
T150
S
N
P
I
G
S
A
T
A
S
S
K
G
S
Y
Site 25
S152
P
I
G
S
A
T
A
S
S
K
G
S
Y
S
S
Site 26
S153
I
G
S
A
T
A
S
S
K
G
S
Y
S
S
Y
Site 27
S156
A
T
A
S
S
K
G
S
Y
S
S
Y
Q
G
I
Site 28
Y157
T
A
S
S
K
G
S
Y
S
S
Y
Q
G
I
I
Site 29
S158
A
S
S
K
G
S
Y
S
S
Y
Q
G
I
I
A
Site 30
S159
S
S
K
G
S
Y
S
S
Y
Q
G
I
I
A
T
Site 31
Y160
S
K
G
S
Y
S
S
Y
Q
G
I
I
A
T
S
Site 32
S207
E
A
A
E
G
A
A
S
E
E
G
E
K
G
L
Site 33
S232
V
E
V
T
T
E
R
S
Q
D
L
C
P
Q
S
Site 34
S239
S
Q
D
L
C
P
Q
S
L
E
D
A
A
S
E
Site 35
S245
Q
S
L
E
D
A
A
S
E
E
S
S
K
Q
K
Site 36
S249
D
A
A
S
E
E
S
S
K
Q
K
G
I
L
S
Site 37
S256
S
K
Q
K
G
I
L
S
H
E
E
E
D
E
E
Site 38
T317
D
V
I
F
Q
E
D
T
S
H
T
S
A
Q
K
Site 39
S333
P
E
L
R
G
P
E
S
P
S
P
K
P
E
Y
Site 40
S335
L
R
G
P
E
S
P
S
P
K
P
E
Y
S
V
Site 41
Y340
S
P
S
P
K
P
E
Y
S
V
I
V
E
V
R
Site 42
S341
P
S
P
K
P
E
Y
S
V
I
V
E
V
R
S
Site 43
S348
S
V
I
V
E
V
R
S
D
D
D
K
D
E
D
Site 44
T356
D
D
D
K
D
E
D
T
H
S
R
K
S
T
V
Site 45
S358
D
K
D
E
D
T
H
S
R
K
S
T
V
T
D
Site 46
S361
E
D
T
H
S
R
K
S
T
V
T
D
E
S
E
Site 47
T362
D
T
H
S
R
K
S
T
V
T
D
E
S
E
M
Site 48
T364
H
S
R
K
S
T
V
T
D
E
S
E
M
Q
D
Site 49
T374
S
E
M
Q
D
M
M
T
R
G
N
L
G
L
L
Site 50
T394
L
K
A
E
Q
V
R
T
V
C
E
P
G
C
P
Site 51
S406
G
C
P
P
A
E
Q
S
Q
L
G
L
G
E
P
Site 52
T422
K
A
A
K
P
L
D
T
V
R
K
S
Y
Y
S
Site 53
S426
P
L
D
T
V
R
K
S
Y
Y
S
K
D
P
S
Site 54
Y427
L
D
T
V
R
K
S
Y
Y
S
K
D
P
S
R
Site 55
Y428
D
T
V
R
K
S
Y
Y
S
K
D
P
S
R
A
Site 56
S429
T
V
R
K
S
Y
Y
S
K
D
P
S
R
A
E
Site 57
S433
S
Y
Y
S
K
D
P
S
R
A
E
K
R
E
I
Site 58
T444
K
R
E
I
K
C
P
T
P
G
C
D
G
T
G
Site 59
T450
P
T
P
G
C
D
G
T
G
H
V
T
G
L
Y
Site 60
Y457
T
G
H
V
T
G
L
Y
P
H
H
R
S
L
S
Site 61
S462
G
L
Y
P
H
H
R
S
L
S
G
C
P
H
K
Site 62
S464
Y
P
H
H
R
S
L
S
G
C
P
H
K
D
R
Site 63
T488
E
N
V
L
K
C
P
T
P
G
C
T
G
Q
G
Site 64
S499
T
G
Q
G
H
V
N
S
N
R
N
T
H
R
S
Site 65
T503
H
V
N
S
N
R
N
T
H
R
S
L
S
G
C
Site 66
S506
S
N
R
N
T
H
R
S
L
S
G
C
P
I
A
Site 67
S508
R
N
T
H
R
S
L
S
G
C
P
I
A
A
A
Site 68
S521
A
A
E
K
L
A
K
S
H
E
K
Q
Q
P
Q
Site 69
T529
H
E
K
Q
Q
P
Q
T
G
D
P
S
K
S
S
Site 70
S533
Q
P
Q
T
G
D
P
S
K
S
S
S
N
S
D
Site 71
S535
Q
T
G
D
P
S
K
S
S
S
N
S
D
R
I
Site 72
S537
G
D
P
S
K
S
S
S
N
S
D
R
I
L
R
Site 73
S539
P
S
K
S
S
S
N
S
D
R
I
L
R
P
M
Site 74
Y557
K
Q
L
E
V
P
P
Y
G
S
Y
R
P
N
V
Site 75
S559
L
E
V
P
P
Y
G
S
Y
R
P
N
V
A
P
Site 76
T568
R
P
N
V
A
P
A
T
P
R
A
N
L
A
K
Site 77
T584
L
E
K
F
S
K
V
T
F
D
Y
A
S
F
D
Site 78
S607
L
A
P
K
I
Q
T
S
E
T
S
P
K
A
F
Site 79
S610
K
I
Q
T
S
E
T
S
P
K
A
F
Q
C
F
Site 80
Y619
K
A
F
Q
C
F
D
Y
S
Q
D
A
E
A
A
Site 81
T649
E
M
P
E
N
L
S
T
K
P
Q
D
L
P
S
Site 82
S656
T
K
P
Q
D
L
P
S
K
S
V
D
I
E
V
Site 83
S658
P
Q
D
L
P
S
K
S
V
D
I
E
V
D
E
Site 84
T668
I
E
V
D
E
N
G
T
L
D
L
S
M
H
K
Site 85
S672
E
N
G
T
L
D
L
S
M
H
K
H
R
K
R
Site 86
S685
K
R
E
N
A
F
P
S
S
S
S
C
S
S
S
Site 87
S686
R
E
N
A
F
P
S
S
S
S
C
S
S
S
P
Site 88
S687
E
N
A
F
P
S
S
S
S
C
S
S
S
P
G
Site 89
S688
N
A
F
P
S
S
S
S
C
S
S
S
P
G
V
Site 90
S690
F
P
S
S
S
S
C
S
S
S
P
G
V
K
S
Site 91
S691
P
S
S
S
S
C
S
S
S
P
G
V
K
S
P
Site 92
S692
S
S
S
S
C
S
S
S
P
G
V
K
S
P
D
Site 93
S697
S
S
S
P
G
V
K
S
P
D
A
S
Q
R
H
Site 94
S701
G
V
K
S
P
D
A
S
Q
R
H
S
S
T
S
Site 95
S705
P
D
A
S
Q
R
H
S
S
T
S
A
P
S
S
Site 96
S706
D
A
S
Q
R
H
S
S
T
S
A
P
S
S
S
Site 97
T707
A
S
Q
R
H
S
S
T
S
A
P
S
S
S
M
Site 98
S708
S
Q
R
H
S
S
T
S
A
P
S
S
S
M
T
Site 99
S711
H
S
S
T
S
A
P
S
S
S
M
T
S
P
Q
Site 100
S712
S
S
T
S
A
P
S
S
S
M
T
S
P
Q
S
Site 101
S713
S
T
S
A
P
S
S
S
M
T
S
P
Q
S
S
Site 102
T715
S
A
P
S
S
S
M
T
S
P
Q
S
S
Q
A
Site 103
S716
A
P
S
S
S
M
T
S
P
Q
S
S
Q
A
S
Site 104
S719
S
S
M
T
S
P
Q
S
S
Q
A
S
R
Q
D
Site 105
S720
S
M
T
S
P
Q
S
S
Q
A
S
R
Q
D
E
Site 106
S723
S
P
Q
S
S
Q
A
S
R
Q
D
E
W
D
R
Site 107
Y734
E
W
D
R
P
L
D
Y
T
K
P
S
R
L
R
Site 108
T735
W
D
R
P
L
D
Y
T
K
P
S
R
L
R
E
Site 109
S738
P
L
D
Y
T
K
P
S
R
L
R
E
E
E
P
Site 110
S748
R
E
E
E
P
E
E
S
E
P
A
A
H
S
F
Site 111
S754
E
S
E
P
A
A
H
S
F
A
S
S
E
A
D
Site 112
S758
A
A
H
S
F
A
S
S
E
A
D
D
Q
E
V
Site 113
S766
E
A
D
D
Q
E
V
S
E
E
N
F
E
E
R
Site 114
Y775
E
N
F
E
E
R
K
Y
P
G
E
V
T
L
T
Site 115
T780
R
K
Y
P
G
E
V
T
L
T
N
F
K
L
K
Site 116
S790
N
F
K
L
K
F
L
S
K
D
I
K
K
E
L
Site 117
T799
D
I
K
K
E
L
L
T
C
P
T
P
G
C
D
Site 118
T802
K
E
L
L
T
C
P
T
P
G
C
D
G
S
G
Site 119
S808
P
T
P
G
C
D
G
S
G
H
I
T
G
N
Y
Site 120
T812
C
D
G
S
G
H
I
T
G
N
Y
A
S
H
R
Site 121
Y815
S
G
H
I
T
G
N
Y
A
S
H
R
S
L
S
Site 122
S817
H
I
T
G
N
Y
A
S
H
R
S
L
S
G
C
Site 123
S820
G
N
Y
A
S
H
R
S
L
S
G
C
P
L
A
Site 124
S822
Y
A
S
H
R
S
L
S
G
C
P
L
A
D
K
Site 125
S839
R
N
L
M
A
A
H
S
A
D
L
K
C
P
T
Site 126
T846
S
A
D
L
K
C
P
T
P
G
C
D
G
S
G
Site 127
S864
G
N
Y
A
S
H
R
S
L
S
G
C
P
R
A
Site 128
S866
Y
A
S
H
R
S
L
S
G
C
P
R
A
K
K
Site 129
S874
G
C
P
R
A
K
K
S
G
V
K
V
A
P
T
Site 130
S905
C
V
G
L
G
H
I
S
G
K
Y
A
S
H
R
Site 131
Y908
L
G
H
I
S
G
K
Y
A
S
H
R
S
A
S
Site 132
S910
H
I
S
G
K
Y
A
S
H
R
S
A
S
G
C
Site 133
S913
G
K
Y
A
S
H
R
S
A
S
G
C
P
L
A
Site 134
S915
Y
A
S
H
R
S
A
S
G
C
P
L
A
A
R
Site 135
S928
A
R
R
Q
K
E
G
S
L
N
G
S
S
F
S
Site 136
S932
K
E
G
S
L
N
G
S
S
F
S
W
K
S
L
Site 137
S933
E
G
S
L
N
G
S
S
F
S
W
K
S
L
K
Site 138
S935
S
L
N
G
S
S
F
S
W
K
S
L
K
N
E
Site 139
S938
G
S
S
F
S
W
K
S
L
K
N
E
G
P
T
Site 140
T948
N
E
G
P
T
C
P
T
P
G
C
D
G
S
G
Site 141
S954
P
T
P
G
C
D
G
S
G
H
A
N
G
S
F
Site 142
S960
G
S
G
H
A
N
G
S
F
L
T
H
R
S
L
Site 143
T963
H
A
N
G
S
F
L
T
H
R
S
L
S
G
C
Site 144
S966
G
S
F
L
T
H
R
S
L
S
G
C
P
R
A
Site 145
S968
F
L
T
H
R
S
L
S
G
C
P
R
A
T
F
Site 146
T974
L
S
G
C
P
R
A
T
F
A
G
K
K
G
K
Site 147
S983
A
G
K
K
G
K
L
S
G
D
E
V
L
S
P
Site 148
S989
L
S
G
D
E
V
L
S
P
K
F
K
T
S
D
Site 149
S995
L
S
P
K
F
K
T
S
D
V
L
E
N
D
E
Site 150
S1017
E
I
R
D
L
N
E
S
N
S
E
M
E
A
A
Site 151
S1019
R
D
L
N
E
S
N
S
E
M
E
A
A
M
V
Site 152
S1030
A
A
M
V
Q
L
Q
S
Q
I
S
S
M
E
K
Site 153
S1033
V
Q
L
Q
S
Q
I
S
S
M
E
K
N
L
K
Site 154
S1034
Q
L
Q
S
Q
I
S
S
M
E
K
N
L
K
N
Site 155
Y1090
C
E
Q
N
F
D
A
Y
V
S
T
L
T
D
M
Site 156
T1095
D
A
Y
V
S
T
L
T
D
M
Y
S
N
Q
D
Site 157
Y1098
V
S
T
L
T
D
M
Y
S
N
Q
D
P
E
N
Site 158
S1099
S
T
L
T
D
M
Y
S
N
Q
D
P
E
N
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation