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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CAP1
Full Name:
Adenylyl cyclase-associated protein 1
Alias:
CAP; CAP 1; CAP, adenylate cyclase-associated protein 1
Type:
Cytoskeletal protein; Actin binding protein
Mass (Da):
51855
Number AA:
475
UniProt ID:
Q01518
International Prot ID:
IPI00008274
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
GO:0007190
GO:0007163
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
V
G
R
L
E
A
V
S
H
T
S
D
M
H
R
Site 2
S25
L
E
A
V
S
H
T
S
D
M
H
R
G
Y
A
Site 3
Y31
T
S
D
M
H
R
G
Y
A
D
S
P
S
K
A
Site 4
S34
M
H
R
G
Y
A
D
S
P
S
K
A
G
A
A
Site 5
S36
R
G
Y
A
D
S
P
S
K
A
G
A
A
P
Y
Site 6
T78
K
H
A
E
M
V
H
T
G
L
K
L
E
R
A
Site 7
T89
L
E
R
A
L
L
V
T
A
S
Q
C
Q
Q
P
Site 8
S91
R
A
L
L
V
T
A
S
Q
C
Q
Q
P
A
E
Site 9
S102
Q
P
A
E
N
K
L
S
D
L
L
A
P
I
S
Site 10
T117
E
Q
I
K
E
V
I
T
F
R
E
K
N
R
G
Site 11
S125
F
R
E
K
N
R
G
S
K
L
F
N
H
L
S
Site 12
S132
S
K
L
F
N
H
L
S
A
V
S
E
S
I
Q
Site 13
Y153
M
A
P
K
P
G
P
Y
V
K
E
M
N
D
A
Site 14
Y164
M
N
D
A
A
M
F
Y
T
N
R
V
L
K
E
Site 15
T165
N
D
A
A
M
F
Y
T
N
R
V
L
K
E
Y
Site 16
Y172
T
N
R
V
L
K
E
Y
K
D
V
D
K
K
H
Site 17
Y196
I
W
T
E
L
Q
A
Y
I
K
E
F
H
T
T
Site 18
T210
T
G
L
A
W
S
K
T
G
P
V
A
K
E
L
Site 19
S218
G
P
V
A
K
E
L
S
G
L
P
S
G
P
S
Site 20
S222
K
E
L
S
G
L
P
S
G
P
S
A
G
S
G
Site 21
S225
S
G
L
P
S
G
P
S
A
G
S
G
P
P
P
Site 22
S228
P
S
G
P
S
A
G
S
G
P
P
P
P
P
P
Site 23
S243
C
P
P
P
P
P
V
S
T
I
S
C
S
Y
E
Site 24
T244
P
P
P
P
P
V
S
T
I
S
C
S
Y
E
S
Site 25
S246
P
P
P
V
S
T
I
S
C
S
Y
E
S
A
S
Site 26
S248
P
V
S
T
I
S
C
S
Y
E
S
A
S
R
S
Site 27
Y249
V
S
T
I
S
C
S
Y
E
S
A
S
R
S
S
Site 28
S251
T
I
S
C
S
Y
E
S
A
S
R
S
S
L
F
Site 29
S253
S
C
S
Y
E
S
A
S
R
S
S
L
F
A
Q
Site 30
S255
S
Y
E
S
A
S
R
S
S
L
F
A
Q
I
N
Site 31
S256
Y
E
S
A
S
R
S
S
L
F
A
Q
I
N
Q
Site 32
S275
T
H
A
L
K
H
V
S
D
D
M
K
T
H
K
Site 33
T280
H
V
S
D
D
M
K
T
H
K
N
P
A
L
K
Site 34
S290
N
P
A
L
K
A
Q
S
G
P
V
R
S
G
P
Site 35
S295
A
Q
S
G
P
V
R
S
G
P
K
P
F
S
A
Site 36
S301
R
S
G
P
K
P
F
S
A
P
K
P
Q
T
S
Site 37
T307
F
S
A
P
K
P
Q
T
S
P
S
P
K
R
A
Site 38
S308
S
A
P
K
P
Q
T
S
P
S
P
K
R
A
T
Site 39
S310
P
K
P
Q
T
S
P
S
P
K
R
A
T
K
K
Site 40
T315
S
P
S
P
K
R
A
T
K
K
E
P
A
V
L
Site 41
T345
S
N
L
V
I
E
D
T
E
L
K
Q
V
A
Y
Site 42
Y352
T
E
L
K
Q
V
A
Y
I
Y
K
C
V
N
T
Site 43
Y354
L
K
Q
V
A
Y
I
Y
K
C
V
N
T
T
L
Site 44
T371
K
G
K
I
N
S
I
T
V
D
N
C
K
K
L
Site 45
T407
Q
V
M
G
K
V
P
T
I
S
I
N
K
T
D
Site 46
S409
M
G
K
V
P
T
I
S
I
N
K
T
D
G
C
Site 47
T413
P
T
I
S
I
N
K
T
D
G
C
H
A
Y
L
Site 48
Y419
K
T
D
G
C
H
A
Y
L
S
K
N
S
L
D
Site 49
S431
S
L
D
C
E
I
V
S
A
K
S
S
E
M
N
Site 50
T459
P
V
P
E
Q
F
K
T
L
W
N
G
Q
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation