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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TIAL1
Full Name:
Nucleolysin TIAR
Alias:
TIA1 cytotoxic granule-associated RNA binding protein-like 1; TIA-1 related protein; TIA-1-related protein; TIAR
Type:
Apoptosis, RNA binding protein
Mass (Da):
41591
Number AA:
375
UniProt ID:
Q01085
International Prot ID:
IPI00644708
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000323
GO:0005764
GO:0005773
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003676
GO:0003702
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0006357
GO:0006915
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
E
D
D
G
Q
P
R
T
L
Y
V
G
N
L
S
Site 2
Y12
D
G
Q
P
R
T
L
Y
V
G
N
L
S
R
D
Site 3
S46
K
M
I
T
E
H
T
S
N
D
P
Y
C
F
V
Site 4
Y50
E
H
T
S
N
D
P
Y
C
F
V
E
F
Y
E
Site 5
Y56
P
Y
C
F
V
E
F
Y
E
H
R
D
A
A
A
Site 6
T84
E
V
K
V
N
W
A
T
T
P
S
S
Q
K
K
Site 7
T85
V
K
V
N
W
A
T
T
P
S
S
Q
K
K
D
Site 8
S88
N
W
A
T
T
P
S
S
Q
K
K
D
T
S
N
Site 9
T93
P
S
S
Q
K
K
D
T
S
N
H
F
H
V
F
Site 10
S94
S
S
Q
K
K
D
T
S
N
H
F
H
V
F
V
Site 11
S105
H
V
F
V
G
D
L
S
P
E
I
T
T
E
D
Site 12
T109
G
D
L
S
P
E
I
T
T
E
D
I
K
S
A
Site 13
S115
I
T
T
E
D
I
K
S
A
F
A
P
F
G
K
Site 14
S124
F
A
P
F
G
K
I
S
D
A
R
V
V
K
D
Site 15
T134
R
V
V
K
D
M
A
T
G
K
S
K
G
Y
G
Site 16
S137
K
D
M
A
T
G
K
S
K
G
Y
G
F
V
S
Site 17
Y140
A
T
G
K
S
K
G
Y
G
F
V
S
F
Y
N
Site 18
S144
S
K
G
Y
G
F
V
S
F
Y
N
K
L
D
A
Site 19
Y146
G
Y
G
F
V
S
F
Y
N
K
L
D
A
E
N
Site 20
T174
Q
I
R
T
N
W
A
T
R
K
P
P
A
P
K
Site 21
S182
R
K
P
P
A
P
K
S
T
Q
E
N
N
T
K
Site 22
S200
F
E
D
V
V
N
Q
S
S
P
K
N
C
T
V
Site 23
S201
E
D
V
V
N
Q
S
S
P
K
N
C
T
V
Y
Site 24
T206
Q
S
S
P
K
N
C
T
V
Y
C
G
G
I
A
Site 25
Y208
S
P
K
N
C
T
V
Y
C
G
G
I
A
S
G
Site 26
T224
T
D
Q
L
M
R
Q
T
F
S
P
F
G
Q
I
Site 27
S226
Q
L
M
R
Q
T
F
S
P
F
G
Q
I
M
E
Site 28
S243
V
F
P
E
K
G
Y
S
F
V
R
F
S
T
H
Site 29
S248
G
Y
S
F
V
R
F
S
T
H
E
S
A
A
H
Site 30
T249
Y
S
F
V
R
F
S
T
H
E
S
A
A
H
A
Site 31
S252
V
R
F
S
T
H
E
S
A
A
H
A
I
V
S
Site 32
Y273
E
G
H
V
V
K
C
Y
W
G
K
E
S
P
D
Site 33
T282
G
K
E
S
P
D
M
T
K
N
F
Q
Q
V
D
Site 34
Y300
W
G
Q
W
S
Q
V
Y
G
N
P
Q
Q
Y
G
Site 35
Y322
Q
V
P
P
Y
G
V
Y
G
Q
P
W
N
Q
Q
Site 36
S336
Q
G
F
G
V
D
Q
S
P
S
A
A
W
M
G
Site 37
Y367
P
P
P
N
Q
A
G
Y
G
M
A
S
Y
Q
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation