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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ECT2L
Full Name:
Epithelial cell-transforming sequence 2 oncogene-like
Alias:
Lung-specific F-box and DH domain-containing protein;Putative guanine nucleotide exchange factor LFDH
Type:
Mass (Da):
104880
Number AA:
904
UniProt ID:
Q008S8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
H
T
R
F
S
A
W
T
P
F
S
N
K
S
L
Site 2
S15
F
S
A
W
T
P
F
S
N
K
S
L
N
R
Q
Site 3
S18
W
T
P
F
S
N
K
S
L
N
R
Q
L
F
Q
Site 4
S57
I
F
L
R
C
T
K
S
Q
L
R
F
V
Q
D
Site 5
T132
F
G
W
F
L
P
Y
T
P
T
D
N
E
Y
G
Site 6
Y138
Y
T
P
T
D
N
E
Y
G
A
W
K
R
H
Y
Site 7
Y145
Y
G
A
W
K
R
H
Y
I
A
C
V
S
H
L
Site 8
T156
V
S
H
L
D
W
L
T
P
R
E
A
A
A
T
Site 9
T163
T
P
R
E
A
A
A
T
Y
G
T
L
N
E
P
Site 10
T172
G
T
L
N
E
P
K
T
E
D
E
E
L
L
E
Site 11
S210
K
V
R
P
P
W
V
S
G
T
C
C
S
S
V
Site 12
T212
R
P
P
W
V
S
G
T
C
C
S
S
V
L
K
Site 13
S216
V
S
G
T
C
C
S
S
V
L
K
P
R
C
Q
Site 14
S227
P
R
C
Q
P
R
L
S
Q
T
V
R
E
R
V
Site 15
T229
C
Q
P
R
L
S
Q
T
V
R
E
R
V
G
L
Site 16
T251
L
V
L
T
S
L
E
T
L
P
K
R
S
N
I
Site 17
S256
L
E
T
L
P
K
R
S
N
I
S
G
S
H
S
Site 18
S259
L
P
K
R
S
N
I
S
G
S
H
S
Y
P
L
Site 19
S261
K
R
S
N
I
S
G
S
H
S
Y
P
L
L
S
Site 20
S263
S
N
I
S
G
S
H
S
Y
P
L
L
S
K
K
Site 21
Y264
N
I
S
G
S
H
S
Y
P
L
L
S
K
K
N
Site 22
S268
S
H
S
Y
P
L
L
S
K
K
N
W
H
G
V
Site 23
S282
V
H
K
N
D
D
R
S
S
Y
A
L
R
P
H
Site 24
S283
H
K
N
D
D
R
S
S
Y
A
L
R
P
H
F
Site 25
Y284
K
N
D
D
R
S
S
Y
A
L
R
P
H
F
M
Site 26
S294
R
P
H
F
M
L
I
S
S
R
I
P
A
Y
E
Site 27
Y300
I
S
S
R
I
P
A
Y
E
M
V
M
E
S
V
Site 28
S340
L
D
G
Q
K
A
Q
S
I
G
I
F
S
D
G
Site 29
S345
A
Q
S
I
G
I
F
S
D
G
D
S
R
E
I
Site 30
S349
G
I
F
S
D
G
D
S
R
E
I
N
L
L
Q
Site 31
S379
D
F
W
E
K
L
G
S
Y
V
A
T
E
E
E
Site 32
Y380
F
W
E
K
L
G
S
Y
V
A
T
E
E
E
G
Site 33
T383
K
L
G
S
Y
V
A
T
E
E
E
G
G
H
V
Site 34
S427
P
T
G
I
A
T
G
S
Y
Q
H
I
L
S
D
Site 35
Y428
T
G
I
A
T
G
S
Y
Q
H
I
L
S
D
W
Site 36
S438
I
L
S
D
W
L
G
S
Q
W
G
K
A
P
S
Site 37
S445
S
Q
W
G
K
A
P
S
S
I
Y
F
C
E
S
Site 38
S446
Q
W
G
K
A
P
S
S
I
Y
F
C
E
S
K
Site 39
Y448
G
K
A
P
S
S
I
Y
F
C
E
S
K
L
Q
Site 40
S452
S
S
I
Y
F
C
E
S
K
L
Q
T
W
S
S
Site 41
T456
F
C
E
S
K
L
Q
T
W
S
S
F
T
D
F
Site 42
S459
S
K
L
Q
T
W
S
S
F
T
D
F
L
E
E
Site 43
T470
F
L
E
E
T
L
K
T
V
R
K
Q
L
Y
P
Site 44
Y476
K
T
V
R
K
Q
L
Y
P
F
F
K
E
L
Q
Site 45
S485
F
F
K
E
L
Q
K
S
I
S
G
R
M
I
G
Site 46
S487
K
E
L
Q
K
S
I
S
G
R
M
I
G
Q
F
Site 47
S522
A
D
G
L
M
E
L
S
K
E
D
S
E
R
N
Site 48
S526
M
E
L
S
K
E
D
S
E
R
N
V
V
E
D
Site 49
S535
R
N
V
V
E
D
N
S
W
D
T
K
S
R
L
Site 50
T538
V
E
D
N
S
W
D
T
K
S
R
L
S
K
N
Site 51
S540
D
N
S
W
D
T
K
S
R
L
S
K
N
D
L
Site 52
S543
W
D
T
K
S
R
L
S
K
N
D
L
N
F
E
Site 53
S577
V
V
R
E
L
L
Q
S
E
R
K
Y
V
Q
I
Site 54
S655
E
I
V
T
K
F
G
S
Q
L
N
T
Y
T
N
Site 55
Y660
F
G
S
Q
L
N
T
Y
T
N
F
F
N
N
Y
Site 56
T673
N
Y
P
V
I
L
K
T
I
E
K
C
R
E
M
Site 57
T686
E
M
I
P
A
F
R
T
F
L
K
R
H
D
K
Site 58
T694
F
L
K
R
H
D
K
T
I
V
T
K
M
L
S
Site 59
T697
R
H
D
K
T
I
V
T
K
M
L
S
L
P
E
Site 60
Y708
S
L
P
E
L
L
L
Y
P
S
R
R
F
E
E
Site 61
S710
P
E
L
L
L
Y
P
S
R
R
F
E
E
Y
L
Site 62
Y716
P
S
R
R
F
E
E
Y
L
N
L
L
Y
A
V
Site 63
Y721
E
E
Y
L
N
L
L
Y
A
V
R
L
H
T
P
Site 64
T727
L
Y
A
V
R
L
H
T
P
A
E
H
V
D
R
Site 65
T738
H
V
D
R
G
D
L
T
T
A
I
D
Q
I
K
Site 66
T739
V
D
R
G
D
L
T
T
A
I
D
Q
I
K
K
Site 67
Y747
A
I
D
Q
I
K
K
Y
K
G
Y
I
D
Q
M
Site 68
Y750
Q
I
K
K
Y
K
G
Y
I
D
Q
M
K
Q
N
Site 69
T776
R
I
I
W
G
C
P
T
L
S
E
V
N
R
Y
Site 70
Y783
T
L
S
E
V
N
R
Y
L
I
R
V
Q
D
V
Site 71
S803
C
D
E
E
I
S
F
S
L
R
L
Y
E
H
I
Site 72
Y807
I
S
F
S
L
R
L
Y
E
H
I
H
D
L
S
Site 73
S825
F
N
D
A
L
L
V
S
S
R
G
T
S
H
T
Site 74
S826
N
D
A
L
L
V
S
S
R
G
T
S
H
T
P
Site 75
T829
L
L
V
S
S
R
G
T
S
H
T
P
F
E
R
Site 76
S830
L
V
S
S
R
G
T
S
H
T
P
F
E
R
T
Site 77
T832
S
S
R
G
T
S
H
T
P
F
E
R
T
S
K
Site 78
T840
P
F
E
R
T
S
K
T
T
Y
Q
F
I
A
S
Site 79
Y842
E
R
T
S
K
T
T
Y
Q
F
I
A
S
V
A
Site 80
S861
L
I
E
N
I
P
D
S
K
Y
V
K
N
A
F
Site 81
Y863
E
N
I
P
D
S
K
Y
V
K
N
A
F
I
L
Site 82
Y875
F
I
L
Q
G
P
K
Y
K
W
I
C
A
T
E
Site 83
S892
D
D
K
F
L
W
L
S
V
L
R
N
A
I
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation