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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLCB2
Full Name:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2
Alias:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2; FLJ38135; Phosphoinositide phospholipase C; Phospholipase C- beta-2; Phospholipase C, beta 2; PLC-beta-2
Type:
Carbohydrate Metabolism - inositol phosphate; Phospholipase; EC 3.1.4.11
Mass (Da):
134024
Number AA:
1185
UniProt ID:
Q00722
International Prot ID:
IPI00784327
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004435
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0007202
GO:0016042
GO:0006644
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
L
P
P
K
V
K
A
Y
L
S
Q
G
E
R
F
Site 2
S18
P
K
V
K
A
Y
L
S
Q
G
E
R
F
I
K
Site 3
S34
D
D
E
T
T
V
A
S
P
V
I
L
R
V
D
Site 4
Y46
R
V
D
P
K
G
Y
Y
L
Y
W
T
Y
Q
S
Site 5
Y48
D
P
K
G
Y
Y
L
Y
W
T
Y
Q
S
K
E
Site 6
Y51
G
Y
Y
L
Y
W
T
Y
Q
S
K
E
M
E
F
Site 7
T62
E
M
E
F
L
D
I
T
S
I
R
D
T
R
F
Site 8
S63
M
E
F
L
D
I
T
S
I
R
D
T
R
F
G
Site 9
T67
D
I
T
S
I
R
D
T
R
F
G
K
F
A
K
Site 10
S78
K
F
A
K
M
P
K
S
Q
K
L
R
D
V
F
Site 11
S93
N
M
D
F
P
D
N
S
F
L
L
K
T
L
T
Site 12
Y118
T
F
H
N
F
V
S
Y
K
E
N
V
G
K
A
Site 13
T139
A
L
V
K
H
P
L
T
A
N
A
S
R
S
T
Site 14
S143
H
P
L
T
A
N
A
S
R
S
T
F
L
D
K
Site 15
S186
K
R
V
E
A
A
L
S
A
C
H
L
P
K
G
Site 16
Y208
E
D
F
P
E
P
V
Y
K
S
F
L
M
S
L
Site 17
S227
E
I
D
E
I
F
T
S
Y
H
A
K
A
K
P
Site 18
S252
I
N
Q
K
Q
R
D
S
R
L
N
S
L
L
F
Site 19
S256
Q
R
D
S
R
L
N
S
L
L
F
P
P
A
R
Site 20
Y274
V
Q
G
L
I
D
K
Y
E
P
S
G
I
N
A
Site 21
S287
N
A
Q
R
G
Q
L
S
P
E
G
M
V
W
F
Site 22
Y321
M
T
Q
P
L
N
H
Y
F
I
N
S
S
H
N
Site 23
T329
F
I
N
S
S
H
N
T
Y
L
T
A
G
Q
F
Site 24
Y330
I
N
S
S
H
N
T
Y
L
T
A
G
Q
F
S
Site 25
T332
S
S
H
N
T
Y
L
T
A
G
Q
F
S
G
L
Site 26
S341
G
Q
F
S
G
L
S
S
A
E
M
Y
R
Q
V
Site 27
T373
P
D
E
E
P
I
I
T
H
G
F
T
M
T
T
Site 28
S406
S
P
Y
P
I
I
L
S
F
E
N
H
V
D
S
Site 29
S413
S
F
E
N
H
V
D
S
P
R
Q
Q
A
K
M
Site 30
Y423
Q
Q
A
K
M
A
E
Y
C
R
T
I
F
G
D
Site 31
S450
K
P
G
V
P
L
P
S
P
E
D
L
R
G
K
Site 32
S468
K
N
K
K
N
Q
F
S
G
P
T
S
S
S
K
Site 33
S472
N
Q
F
S
G
P
T
S
S
S
K
D
T
G
G
Site 34
S473
Q
F
S
G
P
T
S
S
S
K
D
T
G
G
E
Site 35
S474
F
S
G
P
T
S
S
S
K
D
T
G
G
E
A
Site 36
T477
P
T
S
S
S
K
D
T
G
G
E
A
E
G
S
Site 37
S484
T
G
G
E
A
E
G
S
S
P
P
S
A
P
A
Site 38
S485
G
G
E
A
E
G
S
S
P
P
S
A
P
A
G
Site 39
S488
A
E
G
S
S
P
P
S
A
P
A
G
E
G
T
Site 40
T495
S
A
P
A
G
E
G
T
V
W
A
G
E
E
G
Site 41
S518
E
E
E
E
E
E
E
S
G
N
L
D
E
E
E
Site 42
S531
E
E
I
K
K
M
Q
S
D
E
G
T
A
G
L
Site 43
T535
K
M
Q
S
D
E
G
T
A
G
L
E
V
T
A
Site 44
S548
T
A
Y
E
E
M
S
S
L
V
N
Y
I
Q
P
Site 45
Y552
E
M
S
S
L
V
N
Y
I
Q
P
T
K
F
V
Site 46
S560
I
Q
P
T
K
F
V
S
F
E
F
S
A
Q
K
Site 47
S564
K
F
V
S
F
E
F
S
A
Q
K
N
R
S
Y
Site 48
S570
K
N
R
S
Y
V
I
S
S
F
T
E
L
K
A
Site 49
Y571
S
A
Q
K
N
R
S
Y
V
I
S
S
F
T
E
Site 50
S574
K
N
R
S
Y
V
I
S
S
F
T
E
L
K
A
Site 51
S575
N
R
S
Y
V
I
S
S
F
T
E
L
K
A
Y
Site 52
Y582
S
F
T
E
L
K
A
Y
D
L
L
S
K
A
S
Site 53
S589
Y
D
L
L
S
K
A
S
V
Q
F
V
D
Y
N
Site 54
Y595
A
S
V
Q
F
V
D
Y
N
K
R
Q
M
S
R
Site 55
S601
D
Y
N
K
R
Q
M
S
R
I
Y
P
K
G
T
Site 56
Y604
K
R
Q
M
S
R
I
Y
P
K
G
T
R
M
D
Site 57
T608
S
R
I
Y
P
K
G
T
R
M
D
S
S
N
Y
Site 58
S612
P
K
G
T
R
M
D
S
S
N
Y
M
P
Q
M
Site 59
Y654
E
F
N
G
Q
S
G
Y
L
L
K
H
E
F
M
Site 60
S672
D
K
Q
F
N
P
F
S
V
D
R
I
D
V
V
Site 61
S695
V
I
S
G
Q
F
L
S
E
R
S
V
R
T
Y
Site 62
S698
G
Q
F
L
S
E
R
S
V
R
T
Y
V
E
V
Site 63
Y702
S
E
R
S
V
R
T
Y
V
E
V
E
L
F
G
Site 64
Y718
P
G
D
P
K
R
R
Y
R
T
K
L
S
P
S
Site 65
T720
D
P
K
R
R
Y
R
T
K
L
S
P
S
T
N
Site 66
S723
R
R
Y
R
T
K
L
S
P
S
T
N
S
I
N
Site 67
S725
Y
R
T
K
L
S
P
S
T
N
S
I
N
P
V
Site 68
T726
R
T
K
L
S
P
S
T
N
S
I
N
P
V
W
Site 69
S728
K
L
S
P
S
T
N
S
I
N
P
V
W
K
E
Site 70
T828
K
F
F
S
A
H
D
T
K
S
V
K
L
K
E
Site 71
S830
F
S
A
H
D
T
K
S
V
K
L
K
E
A
M
Site 72
S849
E
K
P
F
P
L
A
S
P
V
A
S
Q
V
N
Site 73
T862
V
N
G
A
L
A
P
T
S
N
G
S
P
A
A
Site 74
S863
N
G
A
L
A
P
T
S
N
G
S
P
A
A
R
Site 75
S866
L
A
P
T
S
N
G
S
P
A
A
R
A
G
A
Site 76
S888
A
A
E
P
R
T
A
S
L
E
E
L
R
E
L
Site 77
S953
K
L
G
P
G
K
G
S
R
K
K
R
S
L
P
Site 78
S958
K
G
S
R
K
K
R
S
L
P
R
E
E
S
A
Site 79
S964
R
S
L
P
R
E
E
S
A
G
A
A
P
G
E
Site 80
Y999
L
R
Q
G
E
E
Q
Y
E
C
V
L
K
R
K
Site 81
T1035
E
L
K
A
L
K
E
T
S
E
N
D
T
K
E
Site 82
S1036
L
K
A
L
K
E
T
S
E
N
D
T
K
E
M
Site 83
T1040
K
E
T
S
E
N
D
T
K
E
M
K
K
K
L
Site 84
T1059
L
E
R
I
Q
G
M
T
K
V
T
T
D
K
M
Site 85
S1078
L
K
R
E
I
N
N
S
H
I
Q
E
V
V
Q
Site 86
Y1127
Q
K
E
A
L
A
E
Y
E
A
R
M
K
G
L
Site 87
S1141
L
E
A
E
V
K
E
S
V
R
A
C
L
R
T
Site 88
T1148
S
V
R
A
C
L
R
T
C
F
P
S
E
A
K
Site 89
S1152
C
L
R
T
C
F
P
S
E
A
K
D
K
P
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation