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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HDLBP
Full Name:
Vigilin
Alias:
High density lipoprotein-binding protein; VGL
Type:
RNA binding protein; Lipid binding protein
Mass (Da):
141456
Number AA:
1268
UniProt ID:
Q00341
International Prot ID:
IPI00022228
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003723
GO:0005215
PhosphoSite+
KinaseNET
Biological Process:
GO:0006066
GO:0006629
GO:0006810
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
V
A
V
L
T
Q
E
S
F
A
E
H
R
S
G
Site 2
T28
P
Q
Q
I
K
V
A
T
L
N
S
E
E
E
S
Site 3
S31
I
K
V
A
T
L
N
S
E
E
E
S
D
P
P
Site 4
S35
T
L
N
S
E
E
E
S
D
P
P
T
Y
K
D
Site 5
T39
E
E
E
S
D
P
P
T
Y
K
D
A
F
P
P
Site 6
Y40
E
E
S
D
P
P
T
Y
K
D
A
F
P
P
L
Site 7
S56
E
K
A
A
C
L
E
S
A
Q
E
P
S
G
A
Site 8
S74
K
I
R
P
I
K
A
S
V
I
T
Q
V
F
H
Site 9
Y89
V
P
L
E
E
R
K
Y
K
D
M
N
Q
F
G
Site 10
T111
C
L
E
I
M
Q
R
T
G
A
H
L
E
L
S
Site 11
S118
T
G
A
H
L
E
L
S
L
A
K
D
Q
G
L
Site 12
S126
L
A
K
D
Q
G
L
S
I
M
V
S
G
K
L
Site 13
S152
A
R
L
Q
T
Q
A
S
A
T
V
A
I
P
K
Site 14
S193
I
P
R
P
D
D
P
S
N
Q
I
K
I
T
G
Site 15
S216
R
H
E
V
L
L
I
S
A
E
Q
D
K
R
A
Site 16
S262
R
I
N
I
P
P
P
S
V
N
R
T
E
I
V
Site 17
T266
P
P
P
S
V
N
R
T
E
I
V
F
T
G
E
Site 18
T271
N
R
T
E
I
V
F
T
G
E
K
E
Q
L
A
Site 19
Y288
V
A
R
I
K
K
I
Y
E
E
K
K
K
K
T
Site 20
T296
E
E
K
K
K
K
T
T
T
I
A
V
E
V
K
Site 21
T297
E
K
K
K
K
T
T
T
I
A
V
E
V
K
K
Site 22
S305
I
A
V
E
V
K
K
S
Q
H
K
Y
V
I
G
Site 23
Y309
V
K
K
S
Q
H
K
Y
V
I
G
P
K
G
N
Site 24
S317
V
I
G
P
K
G
N
S
L
Q
E
I
L
E
R
Site 25
S328
I
L
E
R
T
G
V
S
V
E
I
P
P
S
D
Site 26
T340
P
S
D
S
I
S
E
T
V
I
L
R
G
E
P
Site 27
T355
E
K
L
G
Q
A
L
T
E
V
Y
A
K
A
N
Site 28
Y358
G
Q
A
L
T
E
V
Y
A
K
A
N
S
F
T
Site 29
S367
K
A
N
S
F
T
V
S
S
V
A
A
P
S
W
Site 30
T409
T
E
G
E
D
K
I
T
L
E
G
P
T
E
D
Site 31
Y437
D
L
I
N
R
M
D
Y
V
E
I
N
I
D
H
Site 32
S454
H
R
H
L
I
G
K
S
G
A
N
I
N
R
I
Site 33
Y465
I
N
R
I
K
D
Q
Y
K
V
S
V
R
I
P
Site 34
S468
I
K
D
Q
Y
K
V
S
V
R
I
P
P
D
S
Site 35
S475
S
V
R
I
P
P
D
S
E
K
S
N
L
I
R
Site 36
T509
S
R
M
E
N
E
R
T
K
D
L
I
I
E
Q
Site 37
T521
I
E
Q
R
F
H
R
T
I
I
G
Q
K
G
E
Site 38
S551
F
P
D
P
A
Q
K
S
D
I
V
Q
L
R
G
Site 39
Y569
E
V
E
K
C
T
K
Y
M
Q
K
M
V
A
D
Site 40
S581
V
A
D
L
V
E
N
S
Y
S
I
S
V
P
I
Site 41
Y582
A
D
L
V
E
N
S
Y
S
I
S
V
P
I
F
Site 42
S583
D
L
V
E
N
S
Y
S
I
S
V
P
I
F
K
Site 43
S611
I
K
K
I
R
E
E
S
N
T
K
I
D
L
P
Site 44
T613
K
I
R
E
E
S
N
T
K
I
D
L
P
A
E
Site 45
S624
L
P
A
E
N
S
N
S
E
T
I
I
I
T
G
Site 46
T626
A
E
N
S
N
S
E
T
I
I
I
T
G
K
R
Site 47
S641
A
N
C
E
A
A
R
S
R
I
L
S
I
Q
K
Site 48
S645
A
A
R
S
R
I
L
S
I
Q
K
D
L
A
N
Site 49
S659
N
I
A
E
V
E
V
S
I
P
A
K
L
H
N
Site 50
S667
I
P
A
K
L
H
N
S
L
I
G
T
K
G
R
Site 51
T671
L
H
N
S
L
I
G
T
K
G
R
L
I
R
S
Site 52
S678
T
K
G
R
L
I
R
S
I
M
E
E
C
G
G
Site 53
T699
V
E
G
S
G
S
D
T
V
V
I
R
G
P
S
Site 54
S706
T
V
V
I
R
G
P
S
S
D
V
E
K
A
K
Site 55
S707
V
V
I
R
G
P
S
S
D
V
E
K
A
K
K
Site 56
S727
A
E
E
K
Q
T
K
S
F
T
V
D
I
R
A
Site 57
T729
E
K
Q
T
K
S
F
T
V
D
I
R
A
K
P
Site 58
Y738
D
I
R
A
K
P
E
Y
H
K
F
L
I
G
K
Site 59
S756
K
I
R
K
V
R
D
S
T
G
A
R
V
I
F
Site 60
T757
I
R
K
V
R
D
S
T
G
A
R
V
I
F
P
Site 61
T775
D
K
D
Q
D
L
I
T
I
I
G
K
E
D
A
Site 62
S804
L
D
N
V
V
E
D
S
M
L
V
D
P
K
H
Site 63
S836
E
Y
G
G
V
M
V
S
F
P
R
S
G
T
Q
Site 64
S840
V
M
V
S
F
P
R
S
G
T
Q
S
D
K
V
Site 65
T842
V
S
F
P
R
S
G
T
Q
S
D
K
V
T
L
Site 66
S844
F
P
R
S
G
T
Q
S
D
K
V
T
L
K
G
Site 67
T848
G
T
Q
S
D
K
V
T
L
K
G
A
K
D
C
Site 68
T875
E
D
L
E
A
Q
V
T
L
E
C
A
I
P
Q
Site 69
S887
I
P
Q
K
F
H
R
S
V
M
G
P
K
G
S
Site 70
T900
G
S
R
I
Q
Q
I
T
R
D
F
S
V
Q
I
Site 71
S904
Q
Q
I
T
R
D
F
S
V
Q
I
K
F
P
D
Site 72
S944
A
K
D
C
D
P
G
S
P
R
R
C
D
I
I
Site 73
Y986
V
P
F
D
L
H
R
Y
V
I
G
Q
K
G
S
Site 74
S1052
Q
E
D
R
A
L
R
S
F
K
L
S
V
T
V
Site 75
S1056
A
L
R
S
F
K
L
S
V
T
V
D
P
K
Y
Site 76
T1058
R
S
F
K
L
S
V
T
V
D
P
K
Y
H
P
Site 77
Y1063
S
V
T
V
D
P
K
Y
H
P
K
I
I
G
R
Site 78
T1076
G
R
K
G
A
V
I
T
Q
I
R
L
E
H
D
Site 79
T1102
N
Q
P
Q
D
Q
I
T
I
T
G
Y
E
K
N
Site 80
S1129
G
E
L
E
Q
M
V
S
E
D
V
P
L
D
H
Site 81
S1166
V
D
I
R
F
P
Q
S
G
A
P
D
P
N
C
Site 82
T1175
A
P
D
P
N
C
V
T
V
T
G
L
P
E
N
Site 83
Y1210
D
S
E
A
L
Q
V
Y
M
K
P
P
A
H
E
Site 84
S1223
H
E
E
A
K
A
P
S
R
G
F
V
V
R
D
Site 85
T1234
V
V
R
D
A
P
W
T
A
S
S
S
E
K
A
Site 86
S1236
R
D
A
P
W
T
A
S
S
S
E
K
A
P
D
Site 87
S1237
D
A
P
W
T
A
S
S
S
E
K
A
P
D
M
Site 88
S1238
A
P
W
T
A
S
S
S
E
K
A
P
D
M
S
Site 89
S1245
S
E
K
A
P
D
M
S
S
S
E
E
F
P
S
Site 90
S1246
E
K
A
P
D
M
S
S
S
E
E
F
P
S
F
Site 91
S1247
K
A
P
D
M
S
S
S
E
E
F
P
S
F
G
Site 92
S1252
S
S
S
E
E
F
P
S
F
G
A
Q
V
A
P
Site 93
T1261
G
A
Q
V
A
P
K
T
L
P
W
G
P
K
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation