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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPP2R2B
Full Name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Alias:
PP2A subunit B isoform B55-beta;PP2A subunit B isoform PR55-beta;PP2A subunit B isoform R2-beta;PP2A subunit B isoform beta
Type:
Mass (Da):
51710
Number AA:
443
UniProt ID:
Q00005
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
D
T
R
K
I
N
N
S
F
L
R
D
H
S
Y
Site 2
S19
N
S
F
L
R
D
H
S
Y
A
T
E
A
D
I
Site 3
Y20
S
F
L
R
D
H
S
Y
A
T
E
A
D
I
I
Site 4
S28
A
T
E
A
D
I
I
S
T
V
E
F
N
H
T
Site 5
T35
S
T
V
E
F
N
H
T
G
E
L
L
A
T
G
Site 6
T41
H
T
G
E
L
L
A
T
G
D
K
G
G
R
V
Site 7
Y67
Q
V
H
R
R
G
E
Y
N
V
Y
S
T
F
Q
Site 8
Y70
R
R
G
E
Y
N
V
Y
S
T
F
Q
S
H
E
Site 9
Y82
S
H
E
P
E
F
D
Y
L
K
S
L
E
I
E
Site 10
S85
P
E
F
D
Y
L
K
S
L
E
I
E
E
K
I
Site 11
Y105
L
P
Q
Q
N
A
A
Y
F
L
L
S
T
N
D
Site 12
S109
N
A
A
Y
F
L
L
S
T
N
D
K
T
V
K
Site 13
T114
L
L
S
T
N
D
K
T
V
K
L
W
K
V
S
Site 14
S121
T
V
K
L
W
K
V
S
E
R
D
K
R
P
E
Site 15
T144
G
R
L
R
D
P
A
T
I
T
T
L
R
V
P
Site 16
T147
R
D
P
A
T
I
T
T
L
R
V
P
V
L
R
Site 17
S180
T
Y
H
I
N
S
I
S
V
N
S
D
Y
E
T
Site 18
Y185
S
I
S
V
N
S
D
Y
E
T
Y
M
S
A
D
Site 19
T187
S
V
N
S
D
Y
E
T
Y
M
S
A
D
D
L
Site 20
S190
S
D
Y
E
T
Y
M
S
A
D
D
L
R
I
N
Site 21
Y240
H
H
C
N
T
F
V
Y
S
S
S
K
G
T
I
Site 22
S241
H
C
N
T
F
V
Y
S
S
S
K
G
T
I
R
Site 23
S243
N
T
F
V
Y
S
S
S
K
G
T
I
R
L
C
Site 24
T246
V
Y
S
S
S
K
G
T
I
R
L
C
D
M
R
Site 25
S255
R
L
C
D
M
R
A
S
A
L
C
D
R
H
T
Site 26
T262
S
A
L
C
D
R
H
T
K
F
F
E
E
P
E
Site 27
S272
F
E
E
P
E
D
P
S
N
R
S
F
F
S
E
Site 28
S275
P
E
D
P
S
N
R
S
F
F
S
E
I
I
S
Site 29
S278
P
S
N
R
S
F
F
S
E
I
I
S
S
I
S
Site 30
S283
F
F
S
E
I
I
S
S
I
S
D
V
K
F
S
Site 31
S285
S
E
I
I
S
S
I
S
D
V
K
F
S
H
S
Site 32
S292
S
D
V
K
F
S
H
S
G
R
Y
I
M
T
R
Site 33
Y295
K
F
S
H
S
G
R
Y
I
M
T
R
D
Y
L
Site 34
T298
H
S
G
R
Y
I
M
T
R
D
Y
L
T
V
K
Site 35
Y301
R
Y
I
M
T
R
D
Y
L
T
V
K
V
W
D
Site 36
Y319
E
N
R
P
I
E
T
Y
Q
V
H
D
Y
L
R
Site 37
Y324
E
T
Y
Q
V
H
D
Y
L
R
S
K
L
C
S
Site 38
S327
Q
V
H
D
Y
L
R
S
K
L
C
S
L
Y
E
Site 39
S331
Y
L
R
S
K
L
C
S
L
Y
E
N
D
C
I
Site 40
Y333
R
S
K
L
C
S
L
Y
E
N
D
C
I
F
D
Site 41
T355
G
S
D
S
V
I
M
T
G
S
Y
N
N
F
F
Site 42
T369
F
R
M
F
D
R
N
T
K
R
D
V
T
L
E
Site 43
T374
R
N
T
K
R
D
V
T
L
E
A
S
R
E
N
Site 44
S378
R
D
V
T
L
E
A
S
R
E
N
S
K
P
R
Site 45
S382
L
E
A
S
R
E
N
S
K
P
R
A
I
L
K
Site 46
S405
K
R
R
K
D
E
I
S
V
D
S
L
D
F
S
Site 47
S408
K
D
E
I
S
V
D
S
L
D
F
S
K
K
I
Site 48
S412
S
V
D
S
L
D
F
S
K
K
I
L
H
T
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation