KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ARHGAP4
Full Name:
Rho GTPase-activating protein 4
Alias:
C1; KIAA0131; P115; RGC1; RHG04; Rho GTPase activating protein 4; Rho-GAP hematopoietic protein C1; RHOGAP4
Type:
GTPase activating protein, Rac/Rho
Mass (Da):
105026
Number AA:
946
UniProt ID:
P98171
International Prot ID:
IPI00398854
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005925
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005100
GO:0005070
GO:0005085
PhosphoSite+
KinaseNET
Biological Process:
GO:0007266
GO:0006915
GO:0007010
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y17
E
R
G
L
Q
A
E
Y
E
T
Q
V
K
E
M
Site 2
Y63
R
A
E
V
E
L
E
Y
S
R
G
L
E
K
L
Site 3
S64
A
E
V
E
L
E
Y
S
R
G
L
E
K
L
A
Site 4
S75
E
K
L
A
E
R
F
S
S
R
G
G
R
L
G
Site 5
S76
K
L
A
E
R
F
S
S
R
G
G
R
L
G
S
Site 6
S83
S
R
G
G
R
L
G
S
S
R
E
H
Q
S
F
Site 7
S84
R
G
G
R
L
G
S
S
R
E
H
Q
S
F
R
Site 8
S89
G
S
S
R
E
H
Q
S
F
R
K
E
P
S
L
Site 9
S95
Q
S
F
R
K
E
P
S
L
L
S
P
L
H
C
Site 10
S98
R
K
E
P
S
L
L
S
P
L
H
C
W
A
V
Site 11
S114
L
Q
H
T
R
Q
Q
S
R
E
S
A
A
L
S
Site 12
S117
T
R
Q
Q
S
R
E
S
A
A
L
S
E
V
L
Site 13
S133
G
P
L
A
Q
R
L
S
H
I
A
E
D
V
G
Site 14
S146
V
G
R
L
V
K
K
S
R
D
L
E
Q
Q
L
Site 15
Y171
L
Q
T
A
K
K
T
Y
Q
A
Y
H
M
E
S
Site 16
S199
E
E
K
R
A
G
R
S
V
P
T
T
T
A
G
Site 17
T202
R
A
G
R
S
V
P
T
T
T
A
G
A
T
E
Site 18
T203
A
G
R
S
V
P
T
T
T
A
G
A
T
E
A
Site 19
T204
G
R
S
V
P
T
T
T
A
G
A
T
E
A
G
Site 20
S216
E
A
G
P
L
R
K
S
S
L
K
K
G
G
R
Site 21
S217
A
G
P
L
R
K
S
S
L
K
K
G
G
R
L
Site 22
S286
A
L
G
Q
V
L
R
S
Y
T
A
A
E
S
R
Site 23
Y287
L
G
Q
V
L
R
S
Y
T
A
A
E
S
R
T
Site 24
T288
G
Q
V
L
R
S
Y
T
A
A
E
S
R
T
Q
Site 25
S292
R
S
Y
T
A
A
E
S
R
T
Q
A
S
Q
V
Site 26
S297
A
E
S
R
T
Q
A
S
Q
V
Q
G
L
G
S
Site 27
S304
S
Q
V
Q
G
L
G
S
L
E
E
A
V
E
A
Site 28
Y337
C
P
P
L
R
F
D
Y
H
P
H
D
G
D
E
Site 29
T373
Q
S
R
L
D
R
Q
T
I
E
T
E
E
V
N
Site 30
T376
L
D
R
Q
T
I
E
T
E
E
V
N
K
T
L
Site 31
T382
E
T
E
E
V
N
K
T
L
K
A
T
L
Q
A
Site 32
S404
D
D
G
D
V
L
D
S
F
Q
T
S
P
S
T
Site 33
S408
V
L
D
S
F
Q
T
S
P
S
T
E
S
L
K
Site 34
S410
D
S
F
Q
T
S
P
S
T
E
S
L
K
S
T
Site 35
T411
S
F
Q
T
S
P
S
T
E
S
L
K
S
T
S
Site 36
S413
Q
T
S
P
S
T
E
S
L
K
S
T
S
S
D
Site 37
S416
P
S
T
E
S
L
K
S
T
S
S
D
P
G
S
Site 38
T417
S
T
E
S
L
K
S
T
S
S
D
P
G
S
R
Site 39
S418
T
E
S
L
K
S
T
S
S
D
P
G
S
R
Q
Site 40
S419
E
S
L
K
S
T
S
S
D
P
G
S
R
Q
A
Site 41
S423
S
T
S
S
D
P
G
S
R
Q
A
G
R
R
R
Site 42
T438
G
Q
Q
Q
E
T
E
T
F
Y
L
T
K
L
Q
Site 43
Y440
Q
Q
E
T
E
T
F
Y
L
T
K
L
Q
E
Y
Site 44
Y447
Y
L
T
K
L
Q
E
Y
L
S
G
R
S
I
L
Site 45
S449
T
K
L
Q
E
Y
L
S
G
R
S
I
L
A
K
Site 46
S479
D
K
E
E
Q
E
V
S
W
T
Q
Y
T
Q
R
Site 47
T481
E
E
Q
E
V
S
W
T
Q
Y
T
Q
R
K
F
Site 48
Y483
Q
E
V
S
W
T
Q
Y
T
Q
R
K
F
Q
K
Site 49
T484
E
V
S
W
T
Q
Y
T
Q
R
K
F
Q
K
S
Site 50
S491
T
Q
R
K
F
Q
K
S
R
Q
P
R
P
S
S
Site 51
S497
K
S
R
Q
P
R
P
S
S
Q
Y
N
Q
R
L
Site 52
S498
S
R
Q
P
R
P
S
S
Q
Y
N
Q
R
L
F
Site 53
Y500
Q
P
R
P
S
S
Q
Y
N
Q
R
L
F
G
G
Site 54
S545
H
E
G
I
F
R
V
S
G
A
Q
L
R
V
S
Site 55
S552
S
G
A
Q
L
R
V
S
E
I
R
D
A
F
E
Site 56
T610
A
S
S
E
L
E
A
T
A
E
R
V
E
H
V
Site 57
S618
A
E
R
V
E
H
V
S
R
L
L
W
R
L
P
Site 58
Y654
D
E
N
M
M
D
P
Y
N
L
A
V
C
F
G
Site 59
T686
R
V
N
Q
L
V
Q
T
L
I
V
Q
P
D
R
Site 60
T699
D
R
V
F
P
P
L
T
S
L
P
G
P
V
Y
Site 61
S700
R
V
F
P
P
L
T
S
L
P
G
P
V
Y
E
Site 62
Y706
T
S
L
P
G
P
V
Y
E
K
C
M
A
P
P
Site 63
S714
E
K
C
M
A
P
P
S
A
S
C
L
G
D
A
Site 64
S725
L
G
D
A
Q
L
E
S
L
G
A
D
N
E
P
Site 65
S766
G
R
T
A
Q
E
L
S
F
R
R
G
D
V
L
Site 66
S780
L
R
L
H
E
R
A
S
S
D
W
W
R
G
E
Site 67
S781
R
L
H
E
R
A
S
S
D
W
W
R
G
E
H
Site 68
Y799
R
G
L
I
P
H
K
Y
I
T
L
P
A
G
T
Site 69
T801
L
I
P
H
K
Y
I
T
L
P
A
G
T
E
K
Site 70
T817
V
V
G
A
G
L
Q
T
A
G
E
S
G
S
S
Site 71
S821
G
L
Q
T
A
G
E
S
G
S
S
P
E
G
L
Site 72
S823
Q
T
A
G
E
S
G
S
S
P
E
G
L
L
A
Site 73
S824
T
A
G
E
S
G
S
S
P
E
G
L
L
A
S
Site 74
S831
S
P
E
G
L
L
A
S
E
L
V
H
R
P
E
Site 75
T841
V
H
R
P
E
P
C
T
S
P
E
A
M
G
P
Site 76
S842
H
R
P
E
P
C
T
S
P
E
A
M
G
P
S
Site 77
S849
S
P
E
A
M
G
P
S
G
H
R
R
R
C
L
Site 78
S860
R
R
C
L
V
P
A
S
P
E
Q
H
V
E
V
Site 79
S877
A
V
A
Q
N
M
D
S
V
F
K
E
L
L
G
Site 80
S887
K
E
L
L
G
K
T
S
V
R
Q
G
L
G
P
Site 81
S896
R
Q
G
L
G
P
A
S
T
T
S
P
S
P
G
Site 82
T897
Q
G
L
G
P
A
S
T
T
S
P
S
P
G
P
Site 83
S899
L
G
P
A
S
T
T
S
P
S
P
G
P
R
S
Site 84
S901
P
A
S
T
T
S
P
S
P
G
P
R
S
P
K
Site 85
S906
S
P
S
P
G
P
R
S
P
K
A
P
P
S
S
Site 86
S912
R
S
P
K
A
P
P
S
S
R
L
G
R
N
K
Site 87
S913
S
P
K
A
P
P
S
S
R
L
G
R
N
K
G
Site 88
S922
L
G
R
N
K
G
F
S
R
G
P
G
A
P
A
Site 89
S930
R
G
P
G
A
P
A
S
P
S
A
S
H
P
Q
Site 90
S932
P
G
A
P
A
S
P
S
A
S
H
P
Q
G
L
Site 91
S934
A
P
A
S
P
S
A
S
H
P
Q
G
L
D
T
Site 92
T941
S
H
P
Q
G
L
D
T
T
P
K
P
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation