PhosphoNET

           
Protein Info 
   
Short Name:  LRP2
Full Name:  Low-density lipoprotein receptor-related protein 2
Alias:  Calcium sensor; DBS; Glycoprotein 330; Gp330; Heymann nephritis antigen; Low density lipoprotein-related protein 2; Low-density lipoprotein receptor-related 2; Megalin
Type:  Endocytosis protein; Coated pit, membrane, apical plasma membrane, brush border, endosome, lysosome, Endoplasmic reticulum, Endocytic vesicle, Golgi apparatus protein
Mass (Da):  521958
Number AA:  4655
UniProt ID:  P98164
International Prot ID:  IPI00024292
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005905  GO:0016021  GO:0005764 Uniprot OncoNet
Molecular Function:  GO:0017124  GO:0005509  GO:0004872 PhosphoSite+ KinaseNET
Biological Process:  GO:0006629  GO:0006486  GO:0006898 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T563LGWPAGVTLDMISKR
Site 2Y572DMISKRVYWVDSRFD
Site 3Y580WVDSRFDYIETVTYD
Site 4Y586DYIETVTYDGIQRKT
Site 5Y805LYWTDSHYKSISVMR
Site 6S897YFDKIEHSTFDGLDR
Site 7T898FDKIEHSTFDGLDRR
Site 8S1638HRRQVIASDLIIRHP
Site 9Y1856TLHGDIRYRKTLIAN
Site 10S2704GERCGASSFTCSNGR
Site 11Y3242DRVEKRLYWIDTQRQ
Site 12Y4028CRNTKGSYECVCADG
Site 13S4181RYRKWLISTDLDQPA
Site 14T4451GFFHYRRTGSLLPAL
Site 15S4453FHYRRTGSLLPALPK
Site 16S4463PALPKLPSLSSLVKP
Site 17S4465LPKLPSLSSLVKPSE
Site 18S4466PKLPSLSSLVKPSEN
Site 19S4471LSSLVKPSENGNGVT
Site 20T4478SENGNGVTFRSGADL
Site 21S4481GNGVTFRSGADLNMD
Site 22T4498VSGFGPETAIDRSMA
Site 23S4503PETAIDRSMAMSEDF
Site 24Y4526IIFENPMYSARDSAV
Site 25S4527IFENPMYSARDSAVK
Site 26S4531PMYSARDSAVKVVQP
Site 27Y4552ENVDNKNYGSPINPS
Site 28S4554VDNKNYGSPINPSEI
Site 29T4565PSEIVPETNPTSPAA
Site 30S4569VPETNPTSPAADGTQ
Site 31T4575TSPAADGTQVTKWNL
Site 32S4587WNLFKRKSKQTTNFE
Site 33T4590FKRKSKQTTNFENPI
Site 34T4591KRKSKQTTNFENPIY
Site 35Y4598TNFENPIYAQMENEQ
Site 36S4608MENEQKESVAATPPP
Site 37T4612QKESVAATPPPSPSL
Site 38S4616VAATPPPSPSLPAKP
Site 39S4618ATPPPSPSLPAKPKP
Site 40S4627PAKPKPPSRRDPTPT
Site 41T4632PPSRRDPTPTYSATE
Site 42T4634SRRDPTPTYSATEDT
Site 43Y4635RRDPTPTYSATEDTF
Site 44S4636RDPTPTYSATEDTFK
Site 45T4638PTPTYSATEDTFKDT
Site 46T4641TYSATEDTFKDTANL
Site 47T4645TEDTFKDTANLVKED
Site 48S4653ANLVKEDSEV_____
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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