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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGAP8
Full Name:
Rho GTPase-activating protein 8
Alias:
RHG08
Type:
GTPase activating protein, Rac/Rho
Mass (Da):
53484
Number AA:
464
UniProt ID:
P85298
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005096
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
G
Q
D
P
A
L
S
T
S
H
P
F
Y
D
Site 2
T10
G
Q
D
P
A
L
S
T
S
H
P
F
Y
D
V
Site 3
S11
Q
D
P
A
L
S
T
S
H
P
F
Y
D
V
A
Site 4
Y15
L
S
T
S
H
P
F
Y
D
V
A
R
H
G
I
Site 5
T37
R
F
G
R
R
V
V
T
F
S
C
C
R
M
P
Site 6
S39
G
R
R
V
V
T
F
S
C
C
R
M
P
P
S
Site 7
Y57
D
H
Q
R
L
L
E
Y
L
K
Y
T
L
D
Q
Site 8
Y60
R
L
L
E
Y
L
K
Y
T
L
D
Q
Y
V
E
Site 9
Y65
L
K
Y
T
L
D
Q
Y
V
E
N
D
Y
T
I
Site 10
Y70
D
Q
Y
V
E
N
D
Y
T
I
V
Y
F
H
Y
Site 11
Y74
E
N
D
Y
T
I
V
Y
F
H
Y
G
L
N
S
Site 12
Y77
Y
T
I
V
Y
F
H
Y
G
L
N
S
R
N
K
Site 13
S81
Y
F
H
Y
G
L
N
S
R
N
K
P
S
L
G
Site 14
S86
L
N
S
R
N
K
P
S
L
G
W
L
Q
S
A
Site 15
S92
P
S
L
G
W
L
Q
S
A
Y
K
E
F
D
R
Site 16
Y94
L
G
W
L
Q
S
A
Y
K
E
F
D
R
K
D
Site 17
T105
D
R
K
D
G
D
L
T
M
W
P
R
L
V
S
Site 18
S112
T
M
W
P
R
L
V
S
N
S
K
L
K
R
S
Site 19
S114
W
P
R
L
V
S
N
S
K
L
K
R
S
S
H
Site 20
S119
S
N
S
K
L
K
R
S
S
H
L
S
L
P
K
Site 21
S120
N
S
K
L
K
R
S
S
H
L
S
L
P
K
Y
Site 22
S123
L
K
R
S
S
H
L
S
L
P
K
Y
W
D
Y
Site 23
Y127
S
H
L
S
L
P
K
Y
W
D
Y
R
Y
K
K
Site 24
Y130
S
L
P
K
Y
W
D
Y
R
Y
K
K
N
L
K
Site 25
Y132
P
K
Y
W
D
Y
R
Y
K
K
N
L
K
A
L
Site 26
Y140
K
K
N
L
K
A
L
Y
V
V
H
P
T
S
F
Site 27
S160
N
I
L
K
P
L
I
S
H
K
F
G
K
K
V
Site 28
Y169
K
F
G
K
K
V
I
Y
F
N
Y
L
S
E
L
Site 29
Y172
K
K
V
I
Y
F
N
Y
L
S
E
L
H
E
H
Site 30
Y182
E
L
H
E
H
L
K
Y
D
Q
L
V
I
P
P
Site 31
Y194
I
P
P
E
V
L
R
Y
D
E
K
L
Q
S
L
Site 32
S200
R
Y
D
E
K
L
Q
S
L
H
E
G
R
T
P
Site 33
T206
Q
S
L
H
E
G
R
T
P
P
P
T
K
T
P
Site 34
T210
E
G
R
T
P
P
P
T
K
T
P
P
P
R
P
Site 35
T212
R
T
P
P
P
T
K
T
P
P
P
R
P
P
L
Site 36
T221
P
P
R
P
P
L
P
T
Q
Q
F
G
V
S
L
Site 37
Y230
Q
F
G
V
S
L
Q
Y
L
K
D
K
N
Q
G
Site 38
Y250
V
L
R
F
T
V
T
Y
L
R
E
K
G
L
R
Site 39
S265
T
E
G
L
F
R
R
S
A
S
V
Q
T
V
R
Site 40
S267
G
L
F
R
R
S
A
S
V
Q
T
V
R
E
I
Site 41
T270
R
R
S
A
S
V
Q
T
V
R
E
I
Q
R
L
Site 42
Y278
V
R
E
I
Q
R
L
Y
N
Q
G
K
P
V
N
Site 43
Y289
K
P
V
N
F
D
D
Y
G
D
I
H
I
P
A
Site 44
T312
E
L
P
Q
P
L
L
T
F
Q
A
Y
E
Q
I
Site 45
T332
V
E
S
S
L
R
V
T
G
C
R
Q
I
L
R
Site 46
S340
G
C
R
Q
I
L
R
S
L
P
E
H
N
Y
V
Site 47
Y346
R
S
L
P
E
H
N
Y
V
V
L
R
Y
L
M
Site 48
S363
L
H
A
V
S
R
E
S
I
F
N
K
M
N
S
Site 49
Y408
T
E
L
L
I
E
Y
Y
E
K
I
F
S
T
P
Site 50
S413
E
Y
Y
E
K
I
F
S
T
P
E
A
P
G
E
Site 51
T414
Y
Y
E
K
I
F
S
T
P
E
A
P
G
E
H
Site 52
T448
R
T
Q
A
T
G
L
T
K
P
T
L
P
P
S
Site 53
S455
T
K
P
T
L
P
P
S
P
L
M
A
A
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation