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Updated November 2019
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Protein Info
Short Name:
GNAS
Full Name:
Protein ALEX
Alias:
Alternative gene product encoded by XL-exon
Type:
Mass (Da):
67948
Number AA:
626
UniProt ID:
P84996
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
R
P
V
D
P
Q
R
S
P
D
P
T
F
R
S
Site 2
T15
P
Q
R
S
P
D
P
T
F
R
S
S
T
R
H
Site 3
S18
S
P
D
P
T
F
R
S
S
T
R
H
S
G
K
Site 4
S19
P
D
P
T
F
R
S
S
T
R
H
S
G
K
L
Site 5
T20
D
P
T
F
R
S
S
T
R
H
S
G
K
L
E
Site 6
S23
F
R
S
S
T
R
H
S
G
K
L
E
P
M
E
Site 7
S42
L
L
R
K
Q
C
P
S
R
L
N
S
P
A
W
Site 8
S46
Q
C
P
S
R
L
N
S
P
A
W
E
A
S
G
Site 9
S52
N
S
P
A
W
E
A
S
G
L
H
W
S
S
L
Site 10
S57
E
A
S
G
L
H
W
S
S
L
D
S
P
V
G
Site 11
S58
A
S
G
L
H
W
S
S
L
D
S
P
V
G
S
Site 12
S61
L
H
W
S
S
L
D
S
P
V
G
S
M
Q
A
Site 13
S65
S
L
D
S
P
V
G
S
M
Q
A
L
R
P
S
Site 14
S72
S
M
Q
A
L
R
P
S
A
Q
H
S
W
S
P
Site 15
S76
L
R
P
S
A
Q
H
S
W
S
P
E
P
S
V
Site 16
S78
P
S
A
Q
H
S
W
S
P
E
P
S
V
V
P
Site 17
S82
H
S
W
S
P
E
P
S
V
V
P
D
Q
A
W
Site 18
S103
Q
K
K
L
C
P
L
S
L
T
S
L
P
R
E
Site 19
S116
R
E
A
A
V
N
F
S
Y
R
S
Q
T
L
L
Site 20
T121
N
F
S
Y
R
S
Q
T
L
L
Q
E
A
Q
V
Site 21
S132
E
A
Q
V
L
Q
G
S
P
E
L
L
P
R
S
Site 22
S139
S
P
E
L
L
P
R
S
P
K
P
S
G
L
Q
Site 23
S143
L
P
R
S
P
K
P
S
G
L
Q
R
L
A
P
Site 24
S165
L
R
R
L
C
H
L
S
L
M
E
K
D
L
G
Site 25
S184
P
R
G
F
P
E
L
S
H
K
S
T
A
A
A
Site 26
S187
F
P
E
L
S
H
K
S
T
A
A
A
S
S
R
Site 27
T188
P
E
L
S
H
K
S
T
A
A
A
S
S
R
Q
Site 28
S192
H
K
S
T
A
A
A
S
S
R
Q
S
R
P
R
Site 29
S193
K
S
T
A
A
A
S
S
R
Q
S
R
P
R
V
Site 30
S196
A
A
A
S
S
R
Q
S
R
P
R
V
R
S
A
Site 31
S202
Q
S
R
P
R
V
R
S
A
S
L
P
P
R
T
Site 32
S204
R
P
R
V
R
S
A
S
L
P
P
R
T
R
L
Site 33
T209
S
A
S
L
P
P
R
T
R
L
P
S
G
S
Q
Site 34
S213
P
P
R
T
R
L
P
S
G
S
Q
A
P
S
A
Site 35
S215
R
T
R
L
P
S
G
S
Q
A
P
S
A
A
H
Site 36
S219
P
S
G
S
Q
A
P
S
A
A
H
P
K
R
L
Site 37
S227
A
A
H
P
K
R
L
S
D
L
L
L
T
S
R
Site 38
T232
R
L
S
D
L
L
L
T
S
R
A
A
A
P
G
Site 39
S233
L
S
D
L
L
L
T
S
R
A
A
A
P
G
W
Site 40
S242
A
A
A
P
G
W
R
S
P
D
P
R
S
R
L
Site 41
S247
W
R
S
P
D
P
R
S
R
L
A
A
P
P
L
Site 42
T257
A
A
P
P
L
G
S
T
T
L
P
S
T
W
T
Site 43
T258
A
P
P
L
G
S
T
T
L
P
S
T
W
T
A
Site 44
S261
L
G
S
T
T
L
P
S
T
W
T
A
P
Q
S
Site 45
T262
G
S
T
T
L
P
S
T
W
T
A
P
Q
S
R
Site 46
T264
T
T
L
P
S
T
W
T
A
P
Q
S
R
L
T
Site 47
S268
S
T
W
T
A
P
Q
S
R
L
T
A
R
P
S
Site 48
T271
T
A
P
Q
S
R
L
T
A
R
P
S
R
S
P
Site 49
S275
S
R
L
T
A
R
P
S
R
S
P
E
P
Q
I
Site 50
S277
L
T
A
R
P
S
R
S
P
E
P
Q
I
R
E
Site 51
S285
P
E
P
Q
I
R
E
S
E
Q
R
D
P
Q
L
Site 52
Y311
M
P
R
R
E
E
K
Y
P
L
R
G
T
D
P
Site 53
T316
E
K
Y
P
L
R
G
T
D
P
L
P
P
G
Q
Site 54
T341
L
Q
P
Q
P
I
L
T
P
G
Q
P
Q
K
I
Site 55
T350
G
Q
P
Q
K
I
P
T
P
G
Q
H
Q
P
I
Site 56
T359
G
Q
H
Q
P
I
L
T
P
G
H
S
Q
P
I
Site 57
S363
P
I
L
T
P
G
H
S
Q
P
I
P
T
P
G
Site 58
T368
G
H
S
Q
P
I
P
T
P
G
Q
P
L
P
P
Site 59
T380
L
P
P
Q
P
I
P
T
P
G
R
P
L
T
P
Site 60
T386
P
T
P
G
R
P
L
T
P
Q
P
I
P
T
P
Site 61
T392
L
T
P
Q
P
I
P
T
P
G
R
P
L
T
P
Site 62
T398
P
T
P
G
R
P
L
T
P
Q
P
I
Q
M
P
Site 63
S425
L
R
P
G
Q
P
M
S
P
Q
L
R
Q
T
Q
Site 64
T431
M
S
P
Q
L
R
Q
T
Q
G
L
P
L
P
Q
Site 65
S448
L
P
P
G
Q
P
K
S
A
G
R
P
L
Q
P
Site 66
S464
P
P
G
P
D
A
R
S
I
S
D
P
P
A
P
Site 67
S466
G
P
D
A
R
S
I
S
D
P
P
A
P
R
S
Site 68
S473
S
D
P
P
A
P
R
S
R
L
P
I
R
L
L
Site 69
T513
G
W
P
A
A
T
M
T
P
A
E
T
S
P
T
Site 70
S518
T
M
T
P
A
E
T
S
P
T
M
G
P
P
D
Site 71
T520
T
P
A
E
T
S
P
T
M
G
P
P
D
A
S
Site 72
S527
T
M
G
P
P
D
A
S
A
G
F
S
I
G
E
Site 73
S540
G
E
I
A
A
A
E
S
P
S
A
T
Y
S
A
Site 74
T544
A
A
E
S
P
S
A
T
Y
S
A
T
F
S
C
Site 75
S546
E
S
P
S
A
T
Y
S
A
T
F
S
C
K
P
Site 76
T548
P
S
A
T
Y
S
A
T
F
S
C
K
P
S
G
Site 77
S550
A
T
Y
S
A
T
F
S
C
K
P
S
G
A
A
Site 78
S558
C
K
P
S
G
A
A
S
V
D
L
R
V
P
S
Site 79
S565
S
V
D
L
R
V
P
S
P
K
P
R
A
L
S
Site 80
S572
S
P
K
P
R
A
L
S
R
S
R
R
Y
P
W
Site 81
S574
K
P
R
A
L
S
R
S
R
R
Y
P
W
R
R
Site 82
Y577
A
L
S
R
S
R
R
Y
P
W
R
R
S
A
D
Site 83
S582
R
R
Y
P
W
R
R
S
A
D
R
C
A
K
K
Site 84
S593
C
A
K
K
P
W
R
S
G
P
R
S
A
Q
R
Site 85
S597
P
W
R
S
G
P
R
S
A
Q
R
R
N
A
V
Site 86
S605
A
Q
R
R
N
A
V
S
S
S
T
N
N
S
R
Site 87
S606
Q
R
R
N
A
V
S
S
S
T
N
N
S
R
T
Site 88
S607
R
R
N
A
V
S
S
S
T
N
N
S
R
T
K
Site 89
S611
V
S
S
S
T
N
N
S
R
T
K
R
W
A
T
Site 90
T613
S
S
T
N
N
S
R
T
K
R
W
A
T
C
V
Site 91
T618
S
R
T
K
R
W
A
T
C
V
R
T
A
C
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation