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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMF1
Full Name:
TATA element modulatory factor
Alias:
Androgen receptor coactivator 160 kDa protein; ARA160; TATA element modulatory factor 1; TMF
Type:
Nuclear receptor co-regulator; Transcription factor
Mass (Da):
122842
Number AA:
1093
UniProt ID:
P82094
International Prot ID:
IPI00010586
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000139
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003702
GO:0003712
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0006366
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
S
W
F
N
A
S
Q
L
S
S
F
A
K
Site 2
S11
F
N
A
S
Q
L
S
S
F
A
K
Q
A
L
S
Site 3
S18
S
F
A
K
Q
A
L
S
Q
A
Q
K
S
I
D
Site 4
S23
A
L
S
Q
A
Q
K
S
I
D
R
V
L
D
I
Site 5
S36
D
I
Q
E
E
E
P
S
I
W
A
E
T
I
P
Site 6
Y44
I
W
A
E
T
I
P
Y
G
E
P
G
I
S
S
Site 7
S50
P
Y
G
E
P
G
I
S
S
P
V
S
G
G
W
Site 8
S51
Y
G
E
P
G
I
S
S
P
V
S
G
G
W
D
Site 9
S54
P
G
I
S
S
P
V
S
G
G
W
D
T
S
T
Site 10
T59
P
V
S
G
G
W
D
T
S
T
W
G
L
K
S
Site 11
S60
V
S
G
G
W
D
T
S
T
W
G
L
K
S
N
Site 12
T61
S
G
G
W
D
T
S
T
W
G
L
K
S
N
T
Site 13
S66
T
S
T
W
G
L
K
S
N
T
E
P
Q
S
P
Site 14
T68
T
W
G
L
K
S
N
T
E
P
Q
S
P
P
I
Site 15
S72
K
S
N
T
E
P
Q
S
P
P
I
A
S
P
K
Site 16
S77
P
Q
S
P
P
I
A
S
P
K
A
I
T
K
P
Site 17
T82
I
A
S
P
K
A
I
T
K
P
V
R
R
T
V
Site 18
T88
I
T
K
P
V
R
R
T
V
V
D
E
S
E
N
Site 19
S93
R
R
T
V
V
D
E
S
E
N
F
F
S
A
F
Site 20
S98
D
E
S
E
N
F
F
S
A
F
L
S
P
T
D
Site 21
S102
N
F
F
S
A
F
L
S
P
T
D
V
Q
T
I
Site 22
T104
F
S
A
F
L
S
P
T
D
V
Q
T
I
Q
K
Site 23
T108
L
S
P
T
D
V
Q
T
I
Q
K
S
P
V
V
Site 24
S112
D
V
Q
T
I
Q
K
S
P
V
V
S
K
P
P
Site 25
S116
I
Q
K
S
P
V
V
S
K
P
P
A
K
S
Q
Site 26
S122
V
S
K
P
P
A
K
S
Q
R
P
E
E
E
V
Site 27
S131
R
P
E
E
E
V
K
S
S
L
H
E
S
L
H
Site 28
S132
P
E
E
E
V
K
S
S
L
H
E
S
L
H
I
Site 29
S136
V
K
S
S
L
H
E
S
L
H
I
G
Q
S
R
Site 30
S142
E
S
L
H
I
G
Q
S
R
T
P
E
T
T
E
Site 31
T144
L
H
I
G
Q
S
R
T
P
E
T
T
E
S
Q
Site 32
T148
Q
S
R
T
P
E
T
T
E
S
Q
V
K
D
S
Site 33
S150
R
T
P
E
T
T
E
S
Q
V
K
D
S
S
L
Site 34
S156
E
S
Q
V
K
D
S
S
L
C
V
S
G
E
T
Site 35
S169
E
T
L
A
A
G
T
S
S
P
K
T
E
G
K
Site 36
S170
T
L
A
A
G
T
S
S
P
K
T
E
G
K
H
Site 37
T173
A
G
T
S
S
P
K
T
E
G
K
H
E
E
T
Site 38
T180
T
E
G
K
H
E
E
T
V
N
K
E
S
D
M
Site 39
S185
E
E
T
V
N
K
E
S
D
M
K
V
P
T
V
Site 40
T191
E
S
D
M
K
V
P
T
V
S
L
K
V
S
E
Site 41
S199
V
S
L
K
V
S
E
S
V
I
D
V
K
T
T
Site 42
T205
E
S
V
I
D
V
K
T
T
M
E
S
I
S
N
Site 43
S211
K
T
T
M
E
S
I
S
N
T
S
T
Q
S
L
Site 44
T213
T
M
E
S
I
S
N
T
S
T
Q
S
L
T
A
Site 45
T215
E
S
I
S
N
T
S
T
Q
S
L
T
A
E
T
Site 46
S217
I
S
N
T
S
T
Q
S
L
T
A
E
T
K
D
Site 47
S239
Q
K
H
E
D
R
Q
S
N
T
P
S
P
P
V
Site 48
T241
H
E
D
R
Q
S
N
T
P
S
P
P
V
S
T
Site 49
S243
D
R
Q
S
N
T
P
S
P
P
V
S
T
F
S
Site 50
S247
N
T
P
S
P
P
V
S
T
F
S
S
G
T
S
Site 51
T248
T
P
S
P
P
V
S
T
F
S
S
G
T
S
T
Site 52
S250
S
P
P
V
S
T
F
S
S
G
T
S
T
T
S
Site 53
S251
P
P
V
S
T
F
S
S
G
T
S
T
T
S
D
Site 54
S254
S
T
F
S
S
G
T
S
T
T
S
D
I
E
V
Site 55
T255
T
F
S
S
G
T
S
T
T
S
D
I
E
V
L
Site 56
S257
S
S
G
T
S
T
T
S
D
I
E
V
L
D
H
Site 57
S266
I
E
V
L
D
H
E
S
V
I
S
E
S
S
A
Site 58
S269
L
D
H
E
S
V
I
S
E
S
S
A
S
S
R
Site 59
S271
H
E
S
V
I
S
E
S
S
A
S
S
R
Q
E
Site 60
S272
E
S
V
I
S
E
S
S
A
S
S
R
Q
E
T
Site 61
S274
V
I
S
E
S
S
A
S
S
R
Q
E
T
T
D
Site 62
S275
I
S
E
S
S
A
S
S
R
Q
E
T
T
D
S
Site 63
T279
S
A
S
S
R
Q
E
T
T
D
S
K
S
S
L
Site 64
T280
A
S
S
R
Q
E
T
T
D
S
K
S
S
L
H
Site 65
S282
S
R
Q
E
T
T
D
S
K
S
S
L
H
L
M
Site 66
S284
Q
E
T
T
D
S
K
S
S
L
H
L
M
Q
T
Site 67
S285
E
T
T
D
S
K
S
S
L
H
L
M
Q
T
S
Site 68
S297
Q
T
S
F
Q
L
L
S
A
S
A
C
P
E
Y
Site 69
S299
S
F
Q
L
L
S
A
S
A
C
P
E
Y
N
R
Site 70
Y304
S
A
S
A
C
P
E
Y
N
R
L
D
D
F
Q
Site 71
T314
L
D
D
F
Q
K
L
T
E
S
C
C
S
S
D
Site 72
S316
D
F
Q
K
L
T
E
S
C
C
S
S
D
A
F
Site 73
S319
K
L
T
E
S
C
C
S
S
D
A
F
E
R
I
Site 74
S320
L
T
E
S
C
C
S
S
D
A
F
E
R
I
D
Site 75
S328
D
A
F
E
R
I
D
S
F
S
V
Q
S
L
D
Site 76
S330
F
E
R
I
D
S
F
S
V
Q
S
L
D
S
R
Site 77
S333
I
D
S
F
S
V
Q
S
L
D
S
R
S
V
S
Site 78
S336
F
S
V
Q
S
L
D
S
R
S
V
S
E
I
N
Site 79
S338
V
Q
S
L
D
S
R
S
V
S
E
I
N
S
D
Site 80
S340
S
L
D
S
R
S
V
S
E
I
N
S
D
D
E
Site 81
S344
R
S
V
S
E
I
N
S
D
D
E
L
S
G
K
Site 82
S349
I
N
S
D
D
E
L
S
G
K
G
Y
A
L
V
Site 83
Y353
D
E
L
S
G
K
G
Y
A
L
V
P
I
I
V
Site 84
S362
L
V
P
I
I
V
N
S
S
T
P
K
S
K
T
Site 85
T364
P
I
I
V
N
S
S
T
P
K
S
K
T
V
E
Site 86
S367
V
N
S
S
T
P
K
S
K
T
V
E
S
A
E
Site 87
T369
S
S
T
P
K
S
K
T
V
E
S
A
E
G
K
Site 88
S372
P
K
S
K
T
V
E
S
A
E
G
K
S
E
E
Site 89
S377
V
E
S
A
E
G
K
S
E
E
V
N
E
T
L
Site 90
T383
K
S
E
E
V
N
E
T
L
V
I
P
T
E
E
Site 91
S396
E
E
A
E
M
E
E
S
G
R
S
A
T
P
V
Site 92
S399
E
M
E
E
S
G
R
S
A
T
P
V
N
C
E
Site 93
T401
E
E
S
G
R
S
A
T
P
V
N
C
E
Q
P
Site 94
S414
Q
P
D
I
L
V
S
S
T
P
I
N
E
G
Q
Site 95
T415
P
D
I
L
V
S
S
T
P
I
N
E
G
Q
T
Site 96
S436
E
Q
C
E
P
A
E
S
Q
P
E
A
L
S
E
Site 97
S442
E
S
Q
P
E
A
L
S
E
K
E
D
V
C
K
Site 98
T450
E
K
E
D
V
C
K
T
V
E
F
L
N
E
K
Site 99
S467
K
R
E
A
Q
L
L
S
L
S
K
E
K
A
L
Site 100
S469
E
A
Q
L
L
S
L
S
K
E
K
A
L
L
E
Site 101
S493
M
F
R
V
K
E
E
S
S
S
I
S
S
L
K
Site 102
S494
F
R
V
K
E
E
S
S
S
I
S
S
L
K
D
Site 103
S495
R
V
K
E
E
S
S
S
I
S
S
L
K
D
E
Site 104
S497
K
E
E
S
S
S
I
S
S
L
K
D
E
F
T
Site 105
S498
E
E
S
S
S
I
S
S
L
K
D
E
F
T
Q
Site 106
T504
S
S
L
K
D
E
F
T
Q
R
I
A
E
A
E
Site 107
T537
N
I
K
E
E
L
A
T
R
L
N
S
S
E
T
Site 108
S541
E
L
A
T
R
L
N
S
S
E
T
A
D
L
L
Site 109
S542
L
A
T
R
L
N
S
S
E
T
A
D
L
L
K
Site 110
S573
S
K
Q
Q
L
H
N
S
N
I
I
K
K
L
R
Site 111
S655
E
L
E
E
K
N
R
S
I
Q
A
A
L
D
S
Site 112
S662
S
I
Q
A
A
L
D
S
A
Y
K
E
L
T
D
Site 113
Y664
Q
A
A
L
D
S
A
Y
K
E
L
T
D
L
H
Site 114
S687
E
A
Q
E
A
A
L
S
R
E
M
K
A
K
E
Site 115
S697
M
K
A
K
E
E
L
S
A
A
L
E
K
A
Q
Site 116
T713
E
A
R
Q
Q
Q
E
T
L
A
I
Q
V
G
D
Site 117
Y738
A
A
A
R
K
E
D
Y
L
R
H
E
I
G
E
Site 118
S761
E
N
R
N
Q
E
L
S
Q
S
V
S
S
T
T
Site 119
S763
R
N
Q
E
L
S
Q
S
V
S
S
T
T
R
P
Site 120
S765
Q
E
L
S
Q
S
V
S
S
T
T
R
P
L
L
Site 121
T767
L
S
Q
S
V
S
S
T
T
R
P
L
L
R
Q
Site 122
S784
N
L
Q
A
T
L
G
S
Q
T
S
S
W
E
K
Site 123
S787
A
T
L
G
S
Q
T
S
S
W
E
K
L
E
K
Site 124
S788
T
L
G
S
Q
T
S
S
W
E
K
L
E
K
N
Site 125
S797
E
K
L
E
K
N
L
S
D
R
L
G
E
S
Q
Site 126
T818
V
E
R
E
R
A
A
T
E
E
L
L
A
N
K
Site 127
S829
L
A
N
K
I
Q
M
S
S
M
E
S
Q
N
S
Site 128
S830
A
N
K
I
Q
M
S
S
M
E
S
Q
N
S
L
Site 129
S833
I
Q
M
S
S
M
E
S
Q
N
S
L
L
R
Q
Site 130
S836
S
S
M
E
S
Q
N
S
L
L
R
Q
E
N
S
Site 131
S851
R
F
Q
A
Q
L
E
S
E
K
N
R
L
C
K
Site 132
Y866
L
E
D
E
N
N
R
Y
Q
V
E
L
E
N
L
Site 133
Y877
L
E
N
L
K
D
E
Y
V
R
T
L
E
E
T
Site 134
T880
L
K
D
E
Y
V
R
T
L
E
E
T
R
K
E
Site 135
T889
E
E
T
R
K
E
K
T
L
L
N
S
Q
L
E
Site 136
S893
K
E
K
T
L
L
N
S
Q
L
E
M
E
R
M
Site 137
T912
E
R
K
K
A
I
F
T
Q
E
T
I
K
E
K
Site 138
S925
E
K
E
R
K
P
F
S
V
S
S
T
P
T
M
Site 139
S927
E
R
K
P
F
S
V
S
S
T
P
T
M
S
R
Site 140
S928
R
K
P
F
S
V
S
S
T
P
T
M
S
R
S
Site 141
T929
K
P
F
S
V
S
S
T
P
T
M
S
R
S
S
Site 142
T931
F
S
V
S
S
T
P
T
M
S
R
S
S
S
I
Site 143
S933
V
S
S
T
P
T
M
S
R
S
S
S
I
S
G
Site 144
S935
S
T
P
T
M
S
R
S
S
S
I
S
G
V
D
Site 145
S936
T
P
T
M
S
R
S
S
S
I
S
G
V
D
M
Site 146
S937
P
T
M
S
R
S
S
S
I
S
G
V
D
M
A
Site 147
S949
D
M
A
G
L
Q
T
S
F
L
S
Q
D
E
S
Site 148
S952
G
L
Q
T
S
F
L
S
Q
D
E
S
H
D
H
Site 149
S956
S
F
L
S
Q
D
E
S
H
D
H
S
F
G
P
Site 150
S960
Q
D
E
S
H
D
H
S
F
G
P
M
P
I
S
Site 151
S967
S
F
G
P
M
P
I
S
A
N
G
S
N
L
Y
Site 152
S971
M
P
I
S
A
N
G
S
N
L
Y
D
A
V
R
Site 153
Y974
S
A
N
G
S
N
L
Y
D
A
V
R
M
G
A
Site 154
S984
V
R
M
G
A
G
S
S
I
I
E
N
L
Q
S
Site 155
S991
S
I
I
E
N
L
Q
S
Q
L
K
L
R
E
G
Site 156
T1001
K
L
R
E
G
E
I
T
H
L
Q
L
E
I
G
Site 157
T1013
E
I
G
N
L
E
K
T
R
S
I
M
A
E
E
Site 158
S1015
G
N
L
E
K
T
R
S
I
M
A
E
E
L
V
Site 159
Y1052
L
R
D
L
D
Q
R
Y
N
T
I
L
Q
M
Y
Site 160
T1054
D
L
D
Q
R
Y
N
T
I
L
Q
M
Y
G
E
Site 161
T1082
D
V
K
N
M
Y
K
T
Q
I
D
E
L
L
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation