PhosphoNET

           
Protein Info 
   
Short Name:  HSD11B2
Full Name:  Corticosteroid 11-beta-dehydrogenase isozyme 2
Alias:  11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type 2; 11-DH2; AME; AME1; Corticosteroid 11-beta-dehydrogenase 2; DHI2; EC 1.1.1.-; HSD11K; HSD2; Hydroxysteroid (11-beta) dehydrogenase 2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase
Type:  Enzyme - Dehydrogenase
Mass (Da):  44127
Number AA:  405
UniProt ID:  P80365
International Prot ID:  IPI00300050
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005783  GO:0005792   Uniprot OncoNet
Molecular Function:      PhosphoSite+ KinaseNET
Biological Process:  GO:0006704  GO:0055114   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S26ALLQLLRSDLRLGRP
Site 2S70AAGWIALSRLARPQR
Site 3T126PGAIELRTCCSPRLR
Site 4S129IELRTCCSPRLRLLQ
Site 5T140RLLQMDLTKPGDISR
Site 6T152ISRVLEFTKAHTTST
Site 7T216SSRGRIVTVGSPAGD
Site 8Y226SPAGDMPYPCLGAYG
Site 9Y232PYPCLGAYGTSKAAV
Site 10T267IQPGCFKTESVRNVG
Site 11Y295PQELLQAYGKDYIEH
Site 12Y299LQAYGKDYIEHLHGQ
Site 13S310LHGQFLHSLRLAMSD
Site 14Y338AARPRRRYYPGQGLG
Site 15Y339ARPRRRYYPGQGLGL
Site 16Y353LMYFIHYYLPEGLRR
Site 17T383LQPGQPGTTPPQDAA
Site 18T384QPGQPGTTPPQDAAQ
Site 19S396AAQDPNLSPGPSPAV
Site 20S400PNLSPGPSPAVAR__
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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