PhosphoNET

           
Protein Info 
   
Short Name:  PRKDC
Full Name:  DNA-dependent protein kinase catalytic subunit
Alias:  DNA-PK catalytic subunit; DNA-PKcs; DNPK1; EC 2.7.11.1; P460; PRKD; XRCC7
Type:  EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); ATYPICAL group; PIKK family; DNAPK subfamily
Mass (Da):  469089
Number AA:  4128
UniProt ID:  P78527
International Prot ID:  IPI00296337
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005958  GO:0005667   Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0003677  GO:0004677 PhosphoSite+ KinaseNET
Biological Process:  GO:0032869  GO:0006303  GO:0018105 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S11SGAGVRCSLLRLQET
Site 2T18SLLRLQETLSAADRC
Site 3S20LRLQETLSAADRCGA
Site 4S75FVRKSLNSIEFRECR
Site 5S104GQKIAPYSVEIKNTC
Site 6T110YSVEIKNTCTSVYTK
Site 7T137LLIKLLQTFRSSRLM
Site 8S140KLLQTFRSSRLMDEF
Site 9S141LLQTFRSSRLMDEFK
Site 10T169LKKKIPDTVLEKVYE
Site 11S187LLGEVHPSEMINNAE
Site 12S210ELKTQMTSAVREPKL
Site 13S229GCLKGLSSLLCNFTK
Site 14T235SSLLCNFTKSMEEDP
Site 15S237LLCNFTKSMEEDPQT
Site 16T244SMEEDPQTSREIFNF
Site 17Y265PQIDLKRYAVPSAGL
Site 18Y340MHKNKLQYFMEQFYG
Site 19S354GIIRNVDSNNKELSI
Site 20S360DSNNKELSIAIRGYG
Site 21T398RCKQMFLTQTDTGDD
Site 22T402MFLTQTDTGDDRVYQ
Site 23Y408DTGDDRVYQMPSFLQ
Site 24S412DRVYQMPSFLQSVAS
Site 25S445LVVMQIDSFPQYSPK
Site 26Y449QIDSFPQYSPKMQLV
Site 27S450IDSFPQYSPKMQLVC
Site 28S492QGLIRICSKPVVLPK
Site 29S503VLPKGPESESEDHRA
Site 30S505PKGPESESEDHRASG
Site 31S511ESEDHRASGEVRTGK
Site 32T516RASGEVRTGKWKVPT
Site 33Y524GKWKVPTYKDYVDLF
Site 34Y527KVPTYKDYVDLFRHL
Site 35S537LFRHLLSSDQMMDSI
Site 36S543SSDQMMDSILADEAF
Site 37S552LADEAFFSVNSSSES
Site 38S555EAFFSVNSSSESLNH
Site 39S556AFFSVNSSSESLNHL
Site 40S557FFSVNSSSESLNHLL
Site 41S559SVNSSSESLNHLLYD
Site 42Y565ESLNHLLYDEFVKSV
Site 43S621PAKPKDFSAFINLVE
Site 44S650EPWVYSFSYELILQS
Site 45S671SGFYKLLSITVRNAK
Site 46Y682RNAKKIKYFEGVSPK
Site 47S687IKYFEGVSPKSLKHS
Site 48S690FEGVSPKSLKHSPED
Site 49S694SPKSLKHSPEDPEKY
Site 50Y701SPEDPEKYSCFALFV
Site 51Y721VAVKMKQYKDELLAS
Site 52Y779ALEEWSIYIDRHVMQ
Site 53Y788DRHVMQPYYKDILPC
Site 54Y789RHVMQPYYKDILPCL
Site 55S806YLKTSALSDETKNNW
Site 56T837VLKHLKKTKNLSSNE
Site 57S841LKKTKNLSSNEAISL
Site 58S842KKTKNLSSNEAISLE
Site 59S847LSSNEAISLEEIRIR
Site 60T872QINKNLLTVTSSDEM
Site 61S875KNLLTVTSSDEMMKS
Site 62S876NLLTVTSSDEMMKSY
Site 63S882SSDEMMKSYVAWDRE
Site 64Y883SDEMMKSYVAWDREK
Site 65S893WDREKRLSFAVPFRE
Site 66T920RVTELALTASDRQTK
Site 67S922TELALTASDRQTKVA
Site 68T926LTASDRQTKVAACEL
Site 69T946MFMLGKATQMPEGGQ
Site 70Y959GQGAPPMYQLYKRTF
Site 71Y962APPMYQLYKRTFPVL
Site 72Y984DQVTRQLYEPLVMQL
Site 73S1003TNNKKFESQDTVALL
Site 74T1006KKFESQDTVALLEAI
Site 75T1024IVDPVDSTLRDFCGR
Site 76T1045KWSIKQITPQQQEKS
Site 77S1052TPQQQEKSPVNTKSL
Site 78T1056QEKSPVNTKSLFKRL
Site 79S1058KSPVNTKSLFKRLYS
Site 80Y1064KSLFKRLYSLALHPN
Site 81S1065SLFKRLYSLALHPNA
Site 82Y1086SLAFNNIYREFREEE
Site 83S1094REFREEESLVEQFVF
Site 84S1120LAHADEKSLGTIQQC
Site 85S1144IIEKKHVSLNKAKKR
Site 86T1181AHCGRPQTECRHKSI
Site 87S1203PLLPGNRSPNLWLKD
Site 88T1275NTFIGERTVGALQVL
Site 89S1323GAAGNRTSPQEGERY
Site 90Y1330SPQEGERYNYSKCTV
Site 91Y1332QEGERYNYSKCTVVV
Site 92T1347RIMEFTTTLLNTSPE
Site 93S1352TTTLLNTSPEGWKLL
Site 94S1409LMKALKMSPYKDILE
Site 95Y1411KALKMSPYKDILETH
Site 96S1427REKITAQSIEELCAV
Site 97S1470LLHNILPSQSTDLHH
Site 98S1472HNILPSQSTDLHHSV
Site 99S1478QSTDLHHSVGTELLS
Site 100T1481DLHHSVGTELLSLVY
Site 101S1502DERQCLPSLDLSCKQ
Site 102S1546STASLGSSQGSVIHF
Site 103S1549SLGSSQGSVIHFSHG
Site 104Y1558IHFSHGEYFYSLFSE
Site 105S1561SHGEYFYSLFSETIN
Site 106T1569LFSETINTELLKNLD
Site 107S1585AVLELMQSSVDNTKM
Site 108S1604LNGMLDQSFRERANQ
Site 109T1620HQGLKLATTILQHWK
Site 110T1621QGLKLATTILQHWKK
Site 111S1637DSWWAKDSPLETKMA
Site 112S1657AKILQIDSSVSFNTS
Site 113S1658KILQIDSSVSFNTSH
Site 114S1660LQIDSSVSFNTSHGS
Site 115S1664SSVSFNTSHGSFPEV
Site 116S1667SFNTSHGSFPEVFTT
Site 117T1694HLKGQAVTLLPFFTS
Site 118T1700VTLLPFFTSLTGGSL
Site 119S1701TLLPFFTSLTGGSLE
Site 120T1703LPFFTSLTGGSLEEL
Site 121T1733SREFPPGTPRFNNYV
Site 122Y1739GTPRFNNYVDCMKKF
Site 123S1780VMEELFQSSFRRIAR
Site 124S1781MEELFQSSFRRIARR
Site 125S1790RRIARRGSCVTQVGL
Site 126T1793ARRGSCVTQVGLLES
Site 127S1800TQVGLLESVYEMFRK
Site 128Y1802VGLLESVYEMFRKDD
Site 129S1813RKDDPRLSFTRQSFV
Site 130S1818RLSFTRQSFVDRSLL
Site 131S1823RQSFVDRSLLTLLWH
Site 132S1853DAIDVLKSRFTKLNE
Site 133T1856DVLKSRFTKLNESTF
Site 134S1861RFTKLNESTFDTQIT
Site 135T1865LNESTFDTQITKKMG
Site 136Y1881YKILDVMYSRLPKDD
Site 137S1882KILDVMYSRLPKDDV
Site 138T1914EGNELTKTLIKLCYD
Site 139Y1920KTLIKLCYDAFTENM
Site 140Y1940LLERRRLYHCAAYNC
Site 141S1968FYQGFLFSEKPEKNL
Site 142Y1988LIDLKRRYNFPVEVE
Site 143Y2004PMERKKKYIEIRKEA
Site 144S2019REAANGDSDGPSYMS
Site 145S2023NGDSDGPSYMSSLSY
Site 146Y2024GDSDGPSYMSSLSYL
Site 147S2026SDGPSYMSSLSYLAD
Site 148S2027DGPSYMSSLSYLADS
Site 149S2029PSYMSSLSYLADSTL
Site 150Y2030SYMSSLSYLADSTLS
Site 151S2034SLSYLADSTLSEEMS
Site 152T2035LSYLADSTLSEEMSQ
Site 153S2037YLADSTLSEEMSQFD
Site 154S2041STLSEEMSQFDFSTG
Site 155S2046EMSQFDFSTGVQSYS
Site 156T2047MSQFDFSTGVQSYSY
Site 157S2051DFSTGVQSYSYSSQD
Site 158S2053STGVQSYSYSSQDPR
Site 159Y2054TGVQSYSYSSQDPRP
Site 160S2055GVQSYSYSSQDPRPA
Site 161S2056VQSYSYSSQDPRPAT
Site 162T2063SQDPRPATGRFRRRE
Site 163T2075RREQRDPTVHDDVLE
Site 164S2107LVKHMHRSLGPPQGE
Site 165S2117PPQGEEDSVPRDLPS
Site 166S2124SVPRDLPSWMKFLHG
Site 167Y2160TEEVFRPYAKHWLSP
Site 168S2174PLLQLAASENNGGEG
Site 169T2201LSWTGLATPTGVPKD
Site 170S2267FSGKDPNSKDNSVGI
Site 171S2271DPNSKDNSVGIQLLG
Site 172Y2288MANDLPPYDPQCGIQ
Site 173S2297PQCGIQSSEYFQALV
Site 174Y2299CGIQSSEYFQALVNN
Site 175S2308QALVNNMSFVRYKEV
Site 176Y2312NNMSFVRYKEVYAAA
Site 177Y2329VLGLILRYVMERKNI
Site 178S2340RKNILEESLCELVAK
Site 179S2370CLNKVTKSFPPLADR
Site 180Y2412VEGMTELYFQLKSKD
Site 181S2417ELYFQLKSKDFVQVM
Site 182T2467EFVSHPSTTCREQMY
Site 183Y2484LMWIHDNYRDPESET
Site 184S2489DNYRDPESETDNDSQ
Site 185S2495ESETDNDSQEIFKLA
Site 186S2526LIIRNFWSHETRLPS
Site 187T2529RNFWSHETRLPSNTL
Site 188S2533SHETRLPSNTLDRLL
Site 189T2535ETRLPSNTLDRLLAL
Site 190S2544DRLLALNSLYSPKIE
Site 191S2547LALNSLYSPKIEVHF
Site 192S2567NFLLEMTSMSPDYPN
Site 193S2569LLEMTSMSPDYPNPM
Site 194Y2572MTSMSPDYPNPMFEH
Site 195Y2589SECEFQEYTIDSDWR
Site 196S2599DSDWRFRSTVLTPMF
Site 197T2600SDWRFRSTVLTPMFV
Site 198T2603RFRSTVLTPMFVETQ
Site 199T2609LTPMFVETQASQGTL
Site 200S2612MFVETQASQGTLQTR
Site 201T2615ETQASQGTLQTRTQE
Site 202T2618ASQGTLQTRTQEGSL
Site 203T2620QGTLQTRTQEGSLSA
Site 204S2624QTRTQEGSLSARWPV
Site 205S2626RTQEGSLSARWPVAG
Site 206T2638VAGQIRATQQQHDFT
Site 207T2645TQQQHDFTLTQTADG
Site 208T2647QQHDFTLTQTADGRS
Site 209T2649HDFTLTQTADGRSSF
Site 210S2655QTADGRSSFDWLTGS
Site 211T2660RSSFDWLTGSSTDPL
Site 212S2662SFDWLTGSSTDPLVD
Site 213T2664DWLTGSSTDPLVDHT
Site 214T2671TDPLVDHTSPSSDSL
Site 215S2672DPLVDHTSPSSDSLL
Site 216S2674LVDHTSPSSDSLLFA
Site 217S2675VDHTSPSSDSLLFAH
Site 218S2677HTSPSSDSLLFAHKR
Site 219S2685LLFAHKRSERLQRAP
Site 220S2695LQRAPLKSVGPDFGK
Site 221Y2743QEKLSLMYARKGVAE
Site 222S2759KREKEIKSELKMKQD
Site 223Y2772QDAQVVLYRSYRHGD
Site 224S2774AQVVLYRSYRHGDLP
Site 225Y2775QVVLYRSYRHGDLPD
Site 226S2788PDIQIKHSSLITPLQ
Site 227S2789DIQIKHSSLITPLQA
Site 228T2792IKHSSLITPLQAVAQ
Site 229S2814QLFSSLFSGILKEMD
Site 230T2825KEMDKFKTLSEKNNI
Site 231S2827MDKFKTLSEKNNITQ
Site 232Y2930WVELAKLYRSIGEYD
Site 233Y2936LYRSIGEYDVLRGIF
Site 234S2963ALLAEARSDYSEAAK
Site 235Y2965LAEARSDYSEAAKQY
Site 236Y3002ELASLDCYNHLAEWK
Site 237Y3013AEWKSLEYCSTASID
Site 238S3015WKSLEYCSTASIDSE
Site 239T3016KSLEYCSTASIDSEN
Site 240S3018LEYCSTASIDSENPP
Site 241S3021CSTASIDSENPPDLN
Site 242Y3036KIWSEPFYQETYLPY
Site 243Y3040EPFYQETYLPYMIRS
Site 244Y3043YQETYLPYMIRSKLK
Site 245S3060LQGEADQSLLTFIDK
Site 246T3063EADQSLLTFIDKAMH
Site 247S3087LHYSQELSLLYLLQD
Site 248Y3090SQELSLLYLLQDDVD
Site 249Y3101DDVDRAKYYIQNGIQ
Site 250Y3102DVDRAKYYIQNGIQS
Site 251S3116SFMQNYSSIDVLLHQ
Site 252T3127LLHQSRLTKLQSVQA
Site 253S3131SRLTKLQSVQALTEI
Site 254S3143TEIQEFISFISKQGN
Site 255S3146QEFISFISKQGNLSS
Site 256S3152ISKQGNLSSQVPLKR
Site 257S3153SKQGNLSSQVPLKRL
Site 258T3165KRLLNTWTNRYPDAK
Site 259Y3168LNTWTNRYPDAKMDP
Site 260S3191TNRCFFLSKIEEKLT
Site 261T3198SKIEEKLTPLPEDNS
Site 262S3205TPLPEDNSMNVDQDG
Site 263S3215VDQDGDPSDRMEVQE
Site 264S3228QEQEEDISSLIRSCK
Site 265S3229EQEEDISSLIRSCKF
Site 266S3233DISSLIRSCKFSMKM
Site 267S3253ARKQNNFSLAMKLLK
Site 268S3266LKELHKESKTRDDWL
Site 269T3268ELHKESKTRDDWLVS
Site 270Y3280LVSWVQSYCRLSHCR
Site 271S3284VQSYCRLSHCRSRSQ
Site 272S3288CRLSHCRSRSQGCSE
Site 273S3290LSHCRSRSQGCSEQV
Site 274S3294RSRSQGCSEQVLTVL
Site 275S3313LLDENNVSSYLSKNI
Site 276S3317NNVSSYLSKNILAFR
Site 277S3363ARRILELSGSSSEDS
Site 278S3365RILELSGSSSEDSEK
Site 279S3367LELSGSSSEDSEKVI
Site 280S3370SGSSSEDSEKVIAGL
Site 281Y3378EKVIAGLYQRAFQHL
Site 282S3386QRAFQHLSEAVQAAE
Site 283S3400EEEAQPPSWSCGPAA
Site 284S3402EAQPPSWSCGPAAGV
Site 285S3432RKEEENASVIDSAEL
Site 286S3436ENASVIDSAELQAYP
Site 287Y3442DSAELQAYPALVVEK
Site 288S3458LKALKLNSNEARLKF
Site 289Y3475LLQIIERYPEETLSL
Site 290T3479IERYPEETLSLMTKE
Site 291S3481RYPEETLSLMTKEIS
Site 292S3489LMTKEISSVPCWQFI
Site 293S3497VPCWQFISWISHMVA
Site 294S3500WQFISWISHMVALLD
Site 295S3517QAVAVQHSVEEITDN
Site 296Y3525VEEITDNYPQAIVYP
Site 297S3537VYPFIISSESYSFKD
Site 298S3539PFIISSESYSFKDTS
Site 299Y3540FIISSESYSFKDTST
Site 300S3541IISSESYSFKDTSTG
Site 301T3545ESYSFKDTSTGHKNK
Site 302S3546SYSFKDTSTGHKNKE
Site 303S3560EFVARIKSKLDQGGV
Site 304S3579INALDQLSNPELLFK
Site 305S3589ELLFKDWSNDVRAEL
Site 306T3599VRAELAKTPVNKKNI
Site 307Y3610KKNIEKMYERMYAAL
Site 308Y3614EKMYERMYAALGDPK
Site 309T3635FRRKFIQTFGKEFDK
Site 310S3657KLLRMKLSDFNDITN
Site 311T3663LSDFNDITNMLLLKM
Site 312S3674LLKMNKDSKPPGNLK
Site 313S3684PGNLKECSPWMSDFK
Site 314Y3705ELEIPGQYDGRGKPL
Site 315Y3715RGKPLPEYHVRIAGF
Site 316T3727AGFDERVTVMASLRR
Site 317S3731ERVTVMASLRRPKRI
Site 318S3779NGILAQDSACSQRAL
Site 319S3782LAQDSACSQRALQLR
Site 320T3790QRALQLRTYSVVPMT
Site 321Y3791RALQLRTYSVVPMTS
Site 322S3792ALQLRTYSVVPMTSR
Site 323T3811EWLENTVTLKDLLLN
Site 324S3821DLLLNTMSQEEKAAY
Site 325Y3828SQEEKAAYLSDPRAP
Site 326S3830EEKAAYLSDPRAPPC
Site 327Y3855GKHDVGAYMLMYKGA
Site 328Y3859VGAYMLMYKGANRTE
Site 329T3867KGANRTETVTSFRKR
Site 330T3869ANRTETVTSFRKRES
Site 331S3870NRTETVTSFRKRESK
Site 332S3876TSFRKRESKVPADLL
Site 333S3891KRAFVRMSTSPEAFL
Site 334T3950GHAFGSATQFLPVPE
Site 335S3982KETGLMYSIMVHALR
Site 336S3993HALRAFRSDPGLLTN
Site 337S4026KMLKKGGSWIQEINV
Site 338Y4039NVAEKNWYPRQKICY
Site 339Y4046YPRQKICYAKRKLAG
Site 340Y4077KAPAFRDYVAVARGS
Site 341S4084YVAVARGSKDHNIRA
Site 342S4096IRAQEPESGLSEETQ
Site 343S4099QEPESGLSEETQVKC
Site 344T4112KCLMDQATDPNILGR
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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