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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IRX4
Full Name:
Iroquois-class homeodomain protein IRX-4
Alias:
Homeodomain protein IRXA3; Iroquois-class homedomain protein IRX-4; IRXA3
Type:
Mass (Da):
54445
Number AA:
519
UniProt ID:
P78413
International Prot ID:
IPI00019752
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0043565
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0007507
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y3
_
_
_
_
_
M
S
Y
P
Q
F
G
Y
P
Y
Site 2
Y8
M
S
Y
P
Q
F
G
Y
P
Y
S
S
A
P
Q
Site 3
S11
P
Q
F
G
Y
P
Y
S
S
A
P
Q
F
L
M
Site 4
S12
Q
F
G
Y
P
Y
S
S
A
P
Q
F
L
M
A
Site 5
T25
M
A
T
N
S
L
S
T
C
C
E
S
G
G
R
Site 6
T33
C
C
E
S
G
G
R
T
L
A
D
S
G
P
A
Site 7
S37
G
G
R
T
L
A
D
S
G
P
A
A
S
A
Q
Site 8
Y48
A
S
A
Q
A
P
V
Y
C
P
V
Y
E
S
R
Site 9
S66
T
A
R
H
E
L
N
S
A
A
A
L
G
V
Y
Site 10
Y77
L
G
V
Y
G
G
P
Y
G
G
S
Q
G
Y
G
Site 11
S80
Y
G
G
P
Y
G
G
S
Q
G
Y
G
N
Y
V
Site 12
Y83
P
Y
G
G
S
Q
G
Y
G
N
Y
V
T
Y
G
Site 13
Y86
G
S
Q
G
Y
G
N
Y
V
T
Y
G
S
E
A
Site 14
Y89
G
Y
G
N
Y
V
T
Y
G
S
E
A
S
A
F
Site 15
S91
G
N
Y
V
T
Y
G
S
E
A
S
A
F
Y
S
Site 16
S94
V
T
Y
G
S
E
A
S
A
F
Y
S
L
N
S
Site 17
S98
S
E
A
S
A
F
Y
S
L
N
S
F
D
S
K
Site 18
S101
S
A
F
Y
S
L
N
S
F
D
S
K
D
G
S
Site 19
S104
Y
S
L
N
S
F
D
S
K
D
G
S
G
S
A
Site 20
S108
S
F
D
S
K
D
G
S
G
S
A
H
G
G
L
Site 21
S110
D
S
K
D
G
S
G
S
A
H
G
G
L
A
P
Site 22
Y125
A
A
A
A
Y
Y
P
Y
E
P
A
L
G
Q
Y
Site 23
Y132
Y
E
P
A
L
G
Q
Y
P
Y
D
R
Y
G
T
Site 24
Y134
P
A
L
G
Q
Y
P
Y
D
R
Y
G
T
M
D
Site 25
Y137
G
Q
Y
P
Y
D
R
Y
G
T
M
D
S
G
T
Site 26
T139
Y
P
Y
D
R
Y
G
T
M
D
S
G
T
R
R
Site 27
S142
D
R
Y
G
T
M
D
S
G
T
R
R
K
N
A
Site 28
T144
Y
G
T
M
D
S
G
T
R
R
K
N
A
T
R
Site 29
T150
G
T
R
R
K
N
A
T
R
E
T
T
S
T
L
Site 30
T153
R
K
N
A
T
R
E
T
T
S
T
L
K
A
W
Site 31
T154
K
N
A
T
R
E
T
T
S
T
L
K
A
W
L
Site 32
T156
A
T
R
E
T
T
S
T
L
K
A
W
L
Q
E
Site 33
Y169
Q
E
H
R
K
N
P
Y
P
T
K
G
E
K
I
Site 34
T207
L
K
K
E
N
K
M
T
W
P
P
R
N
K
C
Site 35
Y221
C
A
D
E
K
R
P
Y
A
E
G
E
E
E
E
Site 36
S241
A
R
E
E
P
L
K
S
S
K
N
A
E
P
V
Site 37
S258
E
E
K
E
L
E
L
S
D
L
D
D
F
D
P
Site 38
S281
E
L
K
P
P
F
H
S
L
D
G
G
L
E
R
Site 39
S301
D
G
P
V
K
E
A
S
G
A
L
R
M
S
L
Site 40
S325
E
D
L
E
R
A
R
S
C
L
R
S
A
A
A
Site 41
S329
R
A
R
S
C
L
R
S
A
A
A
G
P
E
P
Site 42
S370
E
A
K
P
R
I
W
S
L
A
H
T
A
T
A
Site 43
S415
S
A
P
A
T
S
P
S
V
A
L
P
H
S
G
Site 44
S421
P
S
V
A
L
P
H
S
G
A
L
D
R
H
Q
Site 45
S430
A
L
D
R
H
Q
D
S
P
V
T
S
L
R
N
Site 46
S434
H
Q
D
S
P
V
T
S
L
R
N
W
V
D
G
Site 47
T452
D
P
I
L
R
H
S
T
L
N
Q
A
W
A
T
Site 48
S473
D
P
G
P
L
G
R
S
L
G
A
G
A
N
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation