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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IRX6
Full Name:
Iroquois-class homeodomain protein IRX-6
Alias:
Homeodomain protein IRXB3;Iroquois homeobox protein 6
Type:
Mass (Da):
48240
Number AA:
446
UniProt ID:
P78412
International Prot ID:
IPI00400792
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0043565
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
F
P
H
F
G
H
P
Y
R
G
A
S
Q
F
L
Site 2
S14
G
H
P
Y
R
G
A
S
Q
F
L
A
S
A
S
Site 3
S21
S
Q
F
L
A
S
A
S
S
S
T
T
C
C
E
Site 4
T25
A
S
A
S
S
S
T
T
C
C
E
S
T
Q
R
Site 5
S29
S
S
T
T
C
C
E
S
T
Q
R
S
V
S
D
Site 6
T30
S
T
T
C
C
E
S
T
Q
R
S
V
S
D
V
Site 7
S33
C
C
E
S
T
Q
R
S
V
S
D
V
A
S
G
Site 8
S35
E
S
T
Q
R
S
V
S
D
V
A
S
G
S
T
Site 9
S39
R
S
V
S
D
V
A
S
G
S
T
P
A
P
A
Site 10
S59
Y
D
S
R
L
L
G
S
A
R
P
E
L
G
A
Site 11
Y84
A
A
A
A
A
Q
S
Y
P
G
Y
L
P
Y
S
Site 12
Y87
A
A
Q
S
Y
P
G
Y
L
P
Y
S
P
E
P
Site 13
Y90
S
Y
P
G
Y
L
P
Y
S
P
E
P
P
S
L
Site 14
S91
Y
P
G
Y
L
P
Y
S
P
E
P
P
S
L
Y
Site 15
S96
P
Y
S
P
E
P
P
S
L
Y
G
A
L
N
P
Site 16
Y98
S
P
E
P
P
S
L
Y
G
A
L
N
P
Q
Y
Site 17
Y105
Y
G
A
L
N
P
Q
Y
E
F
K
E
A
A
G
Site 18
S113
E
F
K
E
A
A
G
S
F
T
S
S
L
A
Q
Site 19
Y125
L
A
Q
P
G
A
Y
Y
P
Y
E
R
T
L
G
Site 20
Y127
Q
P
G
A
Y
Y
P
Y
E
R
T
L
G
Q
Y
Site 21
Y134
Y
E
R
T
L
G
Q
Y
Q
Y
E
R
Y
G
A
Site 22
Y136
R
T
L
G
Q
Y
Q
Y
E
R
Y
G
A
V
E
Site 23
Y139
G
Q
Y
Q
Y
E
R
Y
G
A
V
E
L
S
G
Site 24
S145
R
Y
G
A
V
E
L
S
G
A
G
R
R
K
N
Site 25
T154
A
G
R
R
K
N
A
T
R
E
T
T
S
T
L
Site 26
T157
R
K
N
A
T
R
E
T
T
S
T
L
K
A
W
Site 27
T158
K
N
A
T
R
E
T
T
S
T
L
K
A
W
L
Site 28
T160
A
T
R
E
T
T
S
T
L
K
A
W
L
N
E
Site 29
Y173
N
E
H
R
K
N
P
Y
P
T
K
G
E
K
I
Site 30
T211
L
K
K
E
N
K
M
T
W
A
P
K
N
K
G
Site 31
S231
A
E
G
G
E
E
D
S
L
G
C
L
T
A
D
Site 32
T239
L
G
C
L
T
A
D
T
K
E
V
T
A
S
Q
Site 33
S245
D
T
K
E
V
T
A
S
Q
E
A
R
G
L
R
Site 34
S254
E
A
R
G
L
R
L
S
D
L
E
D
L
E
E
Site 35
T277
E
D
E
E
V
V
A
T
A
G
D
R
L
T
E
Site 36
T283
A
T
A
G
D
R
L
T
E
F
R
K
G
A
Q
Site 37
S291
E
F
R
K
G
A
Q
S
L
P
G
P
C
A
A
Site 38
S317
G
L
A
A
P
R
F
S
F
N
D
P
S
G
S
Site 39
S322
R
F
S
F
N
D
P
S
G
S
E
E
A
D
F
Site 40
S324
S
F
N
D
P
S
G
S
E
E
A
D
F
L
S
Site 41
S331
S
E
E
A
D
F
L
S
A
E
T
G
S
P
R
Site 42
S336
F
L
S
A
E
T
G
S
P
R
L
T
M
H
Y
Site 43
T340
E
T
G
S
P
R
L
T
M
H
Y
P
C
L
E
Site 44
Y343
S
P
R
L
T
M
H
Y
P
C
L
E
K
P
R
Site 45
S353
L
E
K
P
R
I
W
S
L
A
H
T
A
T
A
Site 46
S375
P
A
R
P
R
P
R
S
P
E
C
R
M
I
P
Site 47
S388
I
P
G
Q
P
P
A
S
A
R
R
L
S
V
P
Site 48
S393
P
A
S
A
R
R
L
S
V
P
R
D
S
A
C
Site 49
S398
R
L
S
V
P
R
D
S
A
C
D
E
S
S
C
Site 50
S403
R
D
S
A
C
D
E
S
S
C
I
P
K
A
F
Site 51
S404
D
S
A
C
D
E
S
S
C
I
P
K
A
F
G
Site 52
Y439
E
P
V
V
Q
C
Q
Y
P
S
G
A
E
A
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation