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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IRX5
Full Name:
Iroquois-class homeodomain protein IRX-5
Alias:
Homeodomain protein IRXB2; Iroquois homeobox protein 5; IRX2A; IRX-2A; IRXB2
Type:
Nucleus protein
Mass (Da):
50361
Number AA:
483
UniProt ID:
P78411
International Prot ID:
IPI00456865
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0043565
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y3
_
_
_
_
_
M
S
Y
P
Q
G
Y
L
Y
Q
Site 2
Y7
_
M
S
Y
P
Q
G
Y
L
Y
Q
P
S
A
S
Site 3
Y9
S
Y
P
Q
G
Y
L
Y
Q
P
S
A
S
L
A
Site 4
S12
Q
G
Y
L
Y
Q
P
S
A
S
L
A
L
Y
S
Site 5
Y23
A
L
Y
S
C
P
A
Y
S
T
S
V
I
S
G
Site 6
T25
Y
S
C
P
A
Y
S
T
S
V
I
S
G
P
R
Site 7
S26
S
C
P
A
Y
S
T
S
V
I
S
G
P
R
T
Site 8
T33
S
V
I
S
G
P
R
T
D
E
L
G
R
S
S
Site 9
S39
R
T
D
E
L
G
R
S
S
S
G
S
A
F
S
Site 10
S40
T
D
E
L
G
R
S
S
S
G
S
A
F
S
P
Site 11
S41
D
E
L
G
R
S
S
S
G
S
A
F
S
P
Y
Site 12
S43
L
G
R
S
S
S
G
S
A
F
S
P
Y
A
G
Site 13
S46
S
S
S
G
S
A
F
S
P
Y
A
G
S
T
A
Site 14
Y48
S
G
S
A
F
S
P
Y
A
G
S
T
A
F
T
Site 15
T55
Y
A
G
S
T
A
F
T
A
P
S
P
G
Y
N
Site 16
S58
S
T
A
F
T
A
P
S
P
G
Y
N
S
H
L
Site 17
Y61
F
T
A
P
S
P
G
Y
N
S
H
L
Q
Y
G
Site 18
S63
A
P
S
P
G
Y
N
S
H
L
Q
Y
G
A
D
Site 19
Y67
G
Y
N
S
H
L
Q
Y
G
A
D
P
A
A
A
Site 20
Y82
A
A
A
A
F
S
S
Y
V
G
S
P
Y
D
H
Site 21
S85
A
F
S
S
Y
V
G
S
P
Y
D
H
T
P
G
Site 22
Y87
S
S
Y
V
G
S
P
Y
D
H
T
P
G
M
A
Site 23
T90
V
G
S
P
Y
D
H
T
P
G
M
A
G
S
L
Site 24
S96
H
T
P
G
M
A
G
S
L
G
Y
H
P
Y
A
Site 25
Y102
G
S
L
G
Y
H
P
Y
A
A
P
L
G
S
Y
Site 26
S108
P
Y
A
A
P
L
G
S
Y
P
Y
G
D
P
A
Site 27
Y109
Y
A
A
P
L
G
S
Y
P
Y
G
D
P
A
Y
Site 28
Y111
A
P
L
G
S
Y
P
Y
G
D
P
A
Y
R
K
Site 29
Y116
Y
P
Y
G
D
P
A
Y
R
K
N
A
T
R
D
Site 30
T125
K
N
A
T
R
D
A
T
A
T
L
K
A
W
L
Site 31
T127
A
T
R
D
A
T
A
T
L
K
A
W
L
N
E
Site 32
Y140
N
E
H
R
K
N
P
Y
P
T
K
G
E
K
I
Site 33
T178
L
K
K
E
N
K
M
T
W
T
P
R
N
R
S
Site 34
T180
K
E
N
K
M
T
W
T
P
R
N
R
S
E
D
Site 35
S185
T
W
T
P
R
N
R
S
E
D
E
E
E
E
E
Site 36
S227
G
A
E
Q
K
A
A
S
G
C
E
R
L
Q
G
Site 37
T237
E
R
L
Q
G
P
P
T
P
A
G
K
E
T
E
Site 38
S246
A
G
K
E
T
E
G
S
L
S
D
S
D
F
K
Site 39
S248
K
E
T
E
G
S
L
S
D
S
D
F
K
E
P
Site 40
S250
T
E
G
S
L
S
D
S
D
F
K
E
P
P
S
Site 41
S257
S
D
F
K
E
P
P
S
E
G
R
L
D
A
L
Site 42
T270
A
L
Q
G
P
P
R
T
G
G
P
S
P
A
G
Site 43
S274
P
P
R
T
G
G
P
S
P
A
G
P
A
A
A
Site 44
Y291
A
E
D
P
A
P
H
Y
P
A
G
A
P
A
P
Site 45
S315
P
P
G
P
G
G
P
S
V
I
H
S
P
P
P
Site 46
S319
G
G
P
S
V
I
H
S
P
P
P
P
P
P
P
Site 47
S344
L
A
E
I
A
T
S
S
D
K
V
K
D
G
G
Site 48
S357
G
G
G
G
N
E
G
S
P
C
P
P
C
P
G
Site 49
S374
A
G
Q
A
L
G
G
S
R
A
S
P
A
P
A
Site 50
S377
A
L
G
G
S
R
A
S
P
A
P
A
P
S
R
Site 51
S383
A
S
P
A
P
A
P
S
R
S
P
S
A
Q
C
Site 52
S385
P
A
P
A
P
S
R
S
P
S
A
Q
C
P
F
Site 53
S387
P
A
P
S
R
S
P
S
A
Q
C
P
F
P
G
Site 54
T396
Q
C
P
F
P
G
G
T
V
L
S
R
P
L
Y
Site 55
Y403
T
V
L
S
R
P
L
Y
Y
T
A
P
F
Y
P
Site 56
Y404
V
L
S
R
P
L
Y
Y
T
A
P
F
Y
P
G
Site 57
T405
L
S
R
P
L
Y
Y
T
A
P
F
Y
P
G
Y
Site 58
Y409
L
Y
Y
T
A
P
F
Y
P
G
Y
T
N
Y
G
Site 59
Y412
T
A
P
F
Y
P
G
Y
T
N
Y
G
S
F
G
Site 60
Y415
F
Y
P
G
Y
T
N
Y
G
S
F
G
H
L
H
Site 61
T432
P
G
P
G
P
G
P
T
T
G
P
G
S
H
F
Site 62
T433
G
P
G
P
G
P
T
T
G
P
G
S
H
F
N
Site 63
S437
G
P
T
T
G
P
G
S
H
F
N
G
L
N
Q
Site 64
S462
K
D
P
K
M
L
R
S
Q
S
Q
L
D
L
C
Site 65
S464
P
K
M
L
R
S
Q
S
Q
L
D
L
C
K
D
Site 66
S472
Q
L
D
L
C
K
D
S
P
Y
E
L
K
K
G
Site 67
Y474
D
L
C
K
D
S
P
Y
E
L
K
K
G
M
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation