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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KRT83
Full Name:
Keratin, type II cuticular Hb3
Alias:
Hair keratin K2.10;Keratin-83;Type II hair keratin Hb3;Type-II keratin Kb23
Type:
Uncharacterized protein
Mass (Da):
54195
Number AA:
493
UniProt ID:
P78385
International Prot ID:
IPI00297795
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0045095
Uniprot
OncoNet
Molecular Function:
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0008544
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
P
G
N
F
S
C
V
S
A
C
G
P
R
P
S
Site 2
T33
R
P
S
R
C
C
I
T
A
A
P
Y
R
G
I
Site 3
S41
A
A
P
Y
R
G
I
S
C
Y
R
G
L
T
G
Site 4
Y43
P
Y
R
G
I
S
C
Y
R
G
L
T
G
G
F
Site 5
T47
I
S
C
Y
R
G
L
T
G
G
F
G
S
H
S
Site 6
S54
T
G
G
F
G
S
H
S
V
C
G
G
F
R
A
Site 7
S63
C
G
G
F
R
A
G
S
C
G
R
S
F
G
Y
Site 8
S67
R
A
G
S
C
G
R
S
F
G
Y
R
S
G
G
Site 9
Y70
S
C
G
R
S
F
G
Y
R
S
G
G
V
C
G
Site 10
S72
G
R
S
F
G
Y
R
S
G
G
V
C
G
P
S
Site 11
S117
E
E
K
E
Q
I
K
S
L
N
S
R
F
A
A
Site 12
Y146
L
E
T
K
L
Q
F
Y
Q
N
R
E
C
C
Q
Site 13
T166
L
F
A
G
Y
I
E
T
L
R
R
E
A
E
C
Site 14
S178
A
E
C
V
E
A
D
S
G
R
L
A
S
E
L
Site 15
S183
A
D
S
G
R
L
A
S
E
L
N
H
V
Q
E
Site 16
Y199
L
E
G
Y
K
K
K
Y
E
E
E
V
A
L
R
Site 17
T208
E
E
V
A
L
R
A
T
A
E
N
E
F
V
A
Site 18
Y224
K
K
D
V
D
C
A
Y
L
R
K
S
D
L
E
Site 19
S228
D
C
A
Y
L
R
K
S
D
L
E
A
N
V
E
Site 20
Y248
I
D
F
L
R
R
L
Y
E
E
E
I
R
I
L
Site 21
S257
E
E
I
R
I
L
Q
S
H
I
S
D
T
S
V
Site 22
S263
Q
S
H
I
S
D
T
S
V
V
V
K
L
D
N
Site 23
Y287
V
A
E
I
K
A
Q
Y
D
D
I
A
T
R
S
Site 24
S294
Y
D
D
I
A
T
R
S
R
A
E
A
E
S
W
Site 25
S300
R
S
R
A
E
A
E
S
W
Y
R
S
K
C
E
Site 26
Y302
R
A
E
A
E
S
W
Y
R
S
K
C
E
E
M
Site 27
S304
E
A
E
S
W
Y
R
S
K
C
E
E
M
K
A
Site 28
T312
K
C
E
E
M
K
A
T
V
I
R
H
G
E
T
Site 29
T319
T
V
I
R
H
G
E
T
L
R
R
T
K
E
E
Site 30
T323
H
G
E
T
L
R
R
T
K
E
E
I
N
E
L
Site 31
T338
N
R
M
I
Q
R
L
T
A
E
V
E
N
A
K
Site 32
S367
Q
Q
G
E
A
A
L
S
D
A
R
C
K
L
A
Site 33
Y394
M
A
C
L
I
R
E
Y
Q
E
V
M
N
S
K
Site 34
T410
G
L
D
I
E
I
A
T
Y
R
R
L
L
E
G
Site 35
Y411
L
D
I
E
I
A
T
Y
R
R
L
L
E
G
E
Site 36
S456
G
S
R
P
V
T
G
S
V
C
S
A
P
C
N
Site 37
T481
K
P
C
G
Q
L
N
T
T
C
G
G
G
S
C
Site 38
T482
P
C
G
Q
L
N
T
T
C
G
G
G
S
C
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation